Acute Effect of Lorazepam on Brain Activity Measured by Magnetoencephalograpy (MEG) and Electroencephalography (EEG)

NCT01272778 | Unknown

• 1 other identifier: ADE-LDR 10-02
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

This placebo-controlled crossover study is intended to measure the effect of four doses of lorazepam on brain activity measured by magnetoencephalography (MEG) and electroencephalography (EEG). This study will conduct MEG and EEG scans as well as simple cognition testing on 16 healthy male volunteers. On each of five study days subjects will be randomized to receive either 0.2, 0.5, 1.0 or 2.0 mg lorazepam or placebo. Brain activity will be measured by MEG and EEG in each subject a total of 4 times each study day: prior to medication administration and 2, 4, and 6 hours after medication administration. Blood samples to determine medication levels and cognition testing will be performed at pre-medication baseline and immediately after each post-medication scan time. Data will be analyzed to identify changes in brain activity compared to baseline and placebo administration using both standard approaches and the Orasi Synchronous Neural Interaction® (SNI) test. This study will test the hypothesis that dose-response changes in brain functional activity can be accurately measured by MEG/EEG in healthy volunteer subjects after single, acute doses of lorazepam.

Conditions

Healthy Subjects

Outcome Measures

Primary Outcomes (1)

• Correlated Brain Activity using MEG and SNI analysis

  The identification and characterization of a pattern of synchronous brain activity that is specifically altered by administration of ascending doses of lorazepam compared to pre-medication baseline and placebo

  2 hours after dosing with lorazepam

Secondary Outcomes (1)

• Correlated Brain Activity using MEG and standard analyses

  2 hours after dosing with lorazepam

Study Arms (5)

Lorazepam 0.2 mg

EXPERIMENTAL

All subjects receive lorazepam 0.2 mg in this crossover design.

Drug: Lorazepam

Lorazepam, 0.5 mg

EXPERIMENTAL

All subjects receive lorazepam 0.5 mg in this crossover design.

Drug: Lorazepam

Lorazepam, 1.0 mg

EXPERIMENTAL

All subjects receive lorazepam 1.0 mg in this crossover design.

Drug: Lorazepam

Lorazepam, 2.0 mg

EXPERIMENTAL

All subjects receive lorazepam 2.0 mg in this crossover design

Drug: Lorazepam

Sugar pill

PLACEBO COMPARATOR

All subjects receive a sugar pill in this crossover design.

Drug: Placebo

Interventions

Lorazepam DRUG

Oral capsule, 0.2 mg, single acute dose

Lorazepam 0.2 mg

Placebo DRUG

oral capsule, single acute dose

Sugar pill

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subject is male between 18 and 35 years of age at the time of screening.
• Subject understands the study procedures and agrees to participate in the study by giving written informed consent.
• Subject is a non-smoker.
• Subject is judged to be in good health based on medical history and brief physical examination and electrocardiogram.
• Subject has normal or corrected to normal visual and auditory acuity.
• Subject agrees to refrain from caffeine 24 hours prior to and then throughout each Study Day.
• Subject agrees to refrain from using alcohol for 48 hours prior to and then throughout each Study Day.

You may not qualify if:

• Subject has a diagnosis of a significant neurological condition including Alzheimer's disease, Parkinson's disease, vascular dementia, Lewy body dementia or frontal temporal dementia, human immunodeficiency virus, multiple sclerosis, or severe traumatic brain injury.
• Subject has a history of primary psychotic disorder (e.g. schizophrenia, schizoaffective disorder, delusional disorder) or bipolar disorder.
• Subject has a history of seizures, epilepsy, stroke, peripheral neuropathy, head trauma with persistent post-concussive symptoms, ADHD, dyslexia or other clinically significant neurological disease or cognitive impairment.
• Subject has a lifetime or current history of alcohol or substance abuse/dependence.
• Subject has a history of multiple or severe allergies, or has had an anaphylactic reaction or intolerability to prescription or non-prescription drugs. This includes a documented or subject-verified allergy.
• Subject had an MRI 2 weeks prior to Study Day 2.
• Subject has metal braces or pacemaker that may interfere with the MEG scan.
• Subject is unable to complete the MEG scan procedure.
• The investigator has any concern regarding the safe participation of a subject in the study, or if for any other reason the investigator considers the subject inappropriate for study participation

Sponsors & Collaborators

• Orasi Medical, Inc.: lead

Study Sites (1)

Alexian Brothers Neurosciences Institute

Elk Grove Village, Illinois, 60007, United States

RECRUITING

MeSH Terms

Interventions

Lorazepam

Intervention Hierarchy (Ancestors)

Benzodiazepinones; Benzodiazepines; Benzazepines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds

Study Officials

• Concetta Forchetti, MD, PhD

  Alexian Brothers Neurosciences Institute

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christina Kay, MA

CONTACT

847-981-3570; christina.kay@abbhh.net

Donnell Carmichael, PsyD

CONTACT

847-981-5771; donnell.carmichael@abbhh.net

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: DIAGNOSTIC
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: January 5, 2011
• First Posted: January 10, 2011
• Study Start: October 1, 2010
• Primary Completion: April 1, 2011
• Study Completion: April 1, 2011
• Last Updated: January 10, 2011

Record last verified: 2011-01

Locations

US (1)