NCT01347229

Brief Summary

The purpose of the study is to evaluate changes in intraocular pressure (IOP) between sitting and supine body positions and correlate the values obtained with conventional tonometers to the output provided by the investigational device.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2011

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2011

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

May 2, 2011

Completed
2 days until next milestone

First Posted

Study publicly available on registry

May 4, 2011

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2012

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2012

Completed
Last Updated

April 17, 2012

Status Verified

April 1, 2012

Enrollment Period

11 months

First QC Date

May 2, 2011

Last Update Submit

April 16, 2012

Conditions

Keywords

GlaucomaTriggerfishbody position

Outcome Measures

Primary Outcomes (1)

  • Difference in study device signal and GAT IOP between the sitting and supine positions during the sitting-supine sequence

    45 minutes

Secondary Outcomes (3)

  • Difference in Triggerfish® signal and GAT IOP between the sitting and supine positions upon returning to sitting position from supine

    30 minutes

  • IOP measurements with tonopen and pneuma-tonometer in sitting position, and tonopen, pneuma-tonometer and Perkins in supine position

    2 hours

  • Monitoring with study device obtained before Day 2

    20 hours

Interventions

Soft contact lens-based device for the continuous monitoring of IOP fluctuations

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subject is able to provide informed consent
  • Healthy subject, with no previous ocular medical history, with the exception of spectacle vision correction for myopia, hyperopia and astigmatism
  • No more than 4 diopters spherical equivalent
  • No more than 2 diopters cylinder equivalent
  • GAT IOP difference between eyes within 1 mmHg during initial exam
  • GAT IOP differences between initial sitting and supine positions, between left and right eyes, within 2 mmHg during initial exam
  • ≥ 18 years
  • For women with childbearing potential, adequate contraception

You may not qualify if:

  • Subjects with contraindications for wearing contact lenses
  • Severe dry eye syndrome
  • Keratoconus or other corneal abnormality
  • Conjunctival or intraocular inflammation
  • History of eye surgery
  • Full frame metal glasses during SENSIMED Triggerfish® recording
  • Known hypersensitivity to silicone, plaster or ocular anesthesia
  • Pregnancy and lactation
  • Simultaneous participation in other clinical studies

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Assaf Harofeh Medical Center

Ẕerifin, 70300, Israel

Location

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular HypertensionEye Diseases

Study Officials

  • Yaniv Barkana, MD

    Assaf-Harofeh Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

May 2, 2011

First Posted

May 4, 2011

Study Start

April 1, 2011

Primary Completion

March 1, 2012

Study Completion

April 1, 2012

Last Updated

April 17, 2012

Record last verified: 2012-04

Locations