Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
Randomized Phase III Study of Maintenance Therapy With Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC
2 other identifiers
interventional
1,516
1 country
434
Brief Summary
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of non-small cell lung cancer by blocking blood flow to the tumor. Pemetrexed disodium may stop the growth of tumor cells by blocking some enzymes needed for cell growth. It is not yet known whether giving bevacizumab or pemetrexed disodium alone or in combination is more effective in treating non-squamous non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying bevacizumab and pemetrexed disodium alone or in combination after induction therapy to see how well they work in treating patients with advanced non-squamous non-small cell lung cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 lung-cancer
Started Oct 2010
Longer than P75 for phase_3 lung-cancer
434 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 20, 2010
CompletedFirst Posted
Study publicly available on registry
April 21, 2010
CompletedStudy Start
First participant enrolled
October 25, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 31, 2019
CompletedResults Posted
Study results publicly available
February 23, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
August 17, 2021
CompletedJuly 7, 2023
June 1, 2023
8.3 years
April 20, 2010
December 21, 2020
June 20, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Overall Survival
Overall survival is defined as the time from randomization to death or date last known alive. The primary analysis is among patients who were randomized to the maintenance therapy. Patients who received induction therapy only and did not participate in the randomization part of the study were not included in this analysis.
Assessed every 6 weeks during induction therapy and every 3 cycles during maintenance therapy; after discontinuation of study therapy, assessed every 3 months for 2 years and every 6 months for years 3-5
Secondary Outcomes (2)
Progression-free Survival
Assessed every 6 weeks during induction therapy and every 3 cycles during maintenance therapy; after discontinuation of study therapy, assessed every 3 months for 2 years and every 6 months for years 3-5
Response Rate
Assessed every 6 weeks during induction therapy and every 3 cycles during maintenance therapy; after discontinuation of study therapy, assessed every 3 months for 2 years and every 6 months for years 3-5
Other Outcomes (5)
The Association Between Genotypes and Response Rate
Assessed every 6 weeks during induction therapy and every 3 cycles during maintenance therapy; after discontinuation of study therapy, assessed every 3 months for 2 years and every 6 months for years 3-5
The Association Between Bevacizumab and Pemetrexed Population Pharmacokinetics and Patient Specific Covariates With Bevacizumab or Pemetrexed Toxicity
Assessed every 3 weeks while on treatment and for 30 days after the end of treatment
The Frequency of TSER*3 Polymorphisms in NSCLC and the Association Between TSER Polymorphisms and Benefit From Pemetrexed
Assessed every 3 months for 2 years and every 6 months for years 3-5
- +2 more other outcomes
Study Arms (3)
Arm A (Induction then Maintenance with Bevacizumab)
EXPERIMENTALInduction Therapy: Patients receive paclitaxel IV over 3 hours, carboplatin IV over 15-30 minutes, and bevacizumab IV over 30-90 minutes on day 1. Courses repeat every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Maintenance Therapy: Patients achieving complete response, partial response or stable disease following induction therapy are randomized to 1 of 3 treatment arms. Patients in arm A receive bevacizumab IV over 30-90 minutes on day 1 of every cycle until progression or unacceptable toxicity.
Arm B (Induction then Maintenance with Pemetrexed)
EXPERIMENTALInduction Therapy: Patients receive paclitaxel IV over 3 hours, carboplatin IV over 15-30 minutes, and bevacizumab IV over 30-90 minutes on day 1. Courses repeat every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Maintenance Therapy: Patients achieving complete response, partial response or stable disease following induction therapy are randomized to 1 of 3 treatment arms. Patients in arm B receive pemetrexed IV over 10 minutes on day 1 of every cycle until progression or unacceptable toxicity.
Arm C (Induction then Maintenance with Bevacizumab & Pemetrexed)
EXPERIMENTALInduction Therapy: Patients receive paclitaxel IV over 3 hours, carboplatin IV over 15-30 minutes, and bevacizumab IV over 30-90 minutes on day 1. Courses repeat every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Maintenance Therapy: Patients achieving complete response, partial response or stable disease following induction therapy are randomized to 1 of 3 treatment arms. Patients in arm C receive bevacizumab as in arm A and pemetrexed as in arm B.
Interventions
Given IV
Given IV
Given IV
Given IV
Eligibility Criteria
You may qualify if:
- Cytologically or histologically confirmed non-small cell lung cancer (NSCLC)
- Predominant non-squamous histology (NSCLC not otherwise specified allowed). Mixed tumors are categorized by the predominant cell type.
- Stage IV disease including M1a or M1b stages or recurrent disease
- Stage IIIB (T4NX) disease with ipsilateral lung lobe allowed provided patients are not candidates for combined chemotherapy or radiotherapy
- At least 12 months since prior adjuvant chemotherapy
- At least 2 weeks since prior radiotherapy
- Prior carboplatin allowed provided it was given as part of adjuvant chemotherapy
- Patients with brain metastasis must have received local therapy to the brain and have no evidence of progression in the brain for at least 2 weeks from the time of completion of local therapy, prior to registration
- ECOG (Eastern Cooperative Oncology Group) performance status 0-1
- Leukocytes ≥ 3,000/mm\^3
- Absolute neutrophil count ≥ 1,500/mm\^3
- Platelet count ≥ 100,000/mm\^3
- Total bilirubin ≤ institutional upper limit of normal (ULN)
- AST and ALT ≤ 3 times ULN
- Creatinine ≤ institutional ULN OR creatinine clearance ≥ 60 mL/min
- +5 more criteria
You may not qualify if:
- Prior malignancy within the past 3 years except superficial melanoma, basal cell carcinoma, or carcinoma in situ
- Prior systemic chemotherapy for advanced stage lung cancer
- Prior use of paclitaxel, pemetrexed disodium, or bevacizumab
- Major hemoptysis within the past 4 weeks
- Uncontrolled intercurrent illness including, but not limited to, active infection, symptomatic congestive heart failure, unstable angina pectoris, serious cardiac arrhythmia, psychiatric illness/social situations that would limit compliance with study requirements
- History of arterial thrombotic events or major bleeding within the past 12 months
- Major surgery such as thoracotomy, laparotomy, craniotomy, or significant traumatic injury within 6 weeks prior to registration. Biopsy procedures and chest tube insertion are not considered major surgery for the purpose of this protocol.
- Core biopsy within 7 days of registration
- Significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent peripheral arterial thrombosis) within the past 6 months
- Clinically significant cardiovascular disease
- Abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months
- History of serious non-healing wounds, ulcers, or bone fractures
- Cavitary lesions in the lungs
- Pregnant or nursing
- Concurrent anti-retroviral therapy in patients with HIV infection
- +4 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- ECOG-ACRIN Cancer Research Grouplead
- National Cancer Institute (NCI)collaborator
Study Sites (434)
Regional Medical Center
Anniston, Alabama, 36207, United States
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
Fairbanks, Alaska, 99701, United States
North Bay Cancer Center
Fairfield, California, 94533, United States
Todd Cancer Institute at Long Beach Memorial Medical Center
Long Beach, California, 90806, United States
Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
Monterey, California, 93940, United States
Veterans Affairs Medical Center - Palo Alto
Palo Alto, California, 94304, United States
Feather River Hospital Cancer Center
Paradise, California, 95969, United States
Sutter Cancer Center at Roseville Medical Center
Roseville, California, 95661, United States
Sutter Cancer Center
Sacramento, California, 95816, United States
Salinas Valley Memorial Hospital
Salinas, California, 93901, United States
Stanford Cancer Center
Stanford, California, 94305-5824, United States
Aurora Presbyterian Hospital
Aurora, Colorado, 80012, United States
Boulder Community Hospital
Boulder, Colorado, 80301-9019, United States
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, 80933, United States
St. Anthony Central Hospital
Denver, Colorado, 80204, United States
Kaiser Permanente - Denver
Denver, Colorado, 80205, United States
Porter Adventist Hospital
Denver, Colorado, 80210, United States
Presbyterian - St. Luke's Medical Center
Denver, Colorado, 80218, United States
St. Joseph Hospital
Denver, Colorado, 80218, United States
Rose Medical Center
Denver, Colorado, 80220, United States
CCOP - Colorado Cancer Research Program
Denver, Colorado, 80222, United States
Swedish Medical Center
Englewood, Colorado, 80110, United States
Poudre Valley Hospital
Fort Collins, Colorado, 80524, United States
Front Range Cancer Specialists
Fort Collins, Colorado, 80528, United States
North Colorado Medical Center
Greeley, Colorado, 80631, United States
Kaiser Permanente - Lafayette
Lafayette, Colorado, 80026, United States
Littleton Adventist Hospital
Littleton, Colorado, 80122, United States
Sky Ridge Medical Center
Lone Tree, Colorado, 80124, United States
Hope Cancer Care Center at Longmont United Hospital
Longmont, Colorado, 80501, United States
McKee Medical Center
Loveland, Colorado, 80539, United States
Parker Adventist Hospital
Parker, Colorado, 80138, United States
St. Mary - Corwin Regional Medical Center
Pueblo, Colorado, 81004, United States
North Suburban Medical Center
Thornton, Colorado, 80229, United States
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, 80033, United States
Praxair Cancer Center at Danbury Hospital
Danbury, Connecticut, 06810, United States
Helen and Harry Gray Cancer Center at Hartford Hospital
Hartford, Connecticut, 06102-5037, United States
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
Hartford, Connecticut, 06105, United States
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
New Britain, Connecticut, 06050, United States
Kaiser Permanente at Capitol Hill Medical Center
Washington D.C., District of Columbia, 20002, United States
Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
Veterans Affairs Medical Center - Washington, DC
Washington D.C., District of Columbia, 20422, United States
North Broward Medical Center
Deerfield Beach, Florida, 33064-3596, United States
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
Fort Lauderdale, Florida, 33308, United States
Broward General Medical Center Cancer Center
Fort Lauderdale, Florida, 33316, United States
Memorial Cancer Institute at Memorial Regional Hospital
Hollywood, Florida, 33021, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, 33458, United States
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, 33140, United States
Florida Hospital Cancer Institute at Florida Hospital Orlando
Orlando, Florida, 32803-1273, United States
Sacred Heart Cancer Center at Sacred Heart Hospital
Pensacola, Florida, 32504, United States
Sacred Heart Medical Oncology
Pensacola, Florida, 32514, United States
Cleveland Clinic Florida - Weston
Weston, Florida, 33331, United States
Phoebe Cancer Center at Phoebe Putney Memorial Hospital
Albany, Georgia, 31701, United States
Winship Cancer Institute of Emory University
Atlanta, Georgia, 30322, United States
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, 30033, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
Savannah, Georgia, 31405, United States
Pearlman Comprehensive Cancer Center at South Georgia Medical Center
Valdosta, Georgia, 31602, United States
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise, Idaho, 83706, United States
Mountain States Tumor Institute at St. Luke's Regional Medical Center
Boise, Idaho, 83712, United States
Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, Idaho, 83619, United States
St. Joseph Regional Medical Center
Lewiston, Idaho, 83501, United States
Mountain States Tumor Institute - Meridian
Meridian, Idaho, 83642, United States
Saint Luke's Mountain States Tumor Institute
Nampa, Idaho, 83686, United States
Mountain States Tumor Institute at St. Luke's
Twin Falls, Idaho, 83301, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, 60504, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, 60611-3013, United States
Hematology and Oncology Associates
Chicago, Illinois, 60611, United States
University of Illinois Cancer Center
Chicago, Illinois, 60612-7243, United States
Veterans Affairs Medical Center - Chicago Westside Hospital
Chicago, Illinois, 60612, United States
Swedish Covenant Hospital
Chicago, Illinois, 60625, United States
Resurrection Medical Center
Chicago, Illinois, 60631, United States
Louis A. Weiss Memorial Hospital
Chicago, Illinois, 60640, United States
Saint Joseph Hospital
Chicago, Illinois, 60657, United States
Elmhurst Memorial Hospital
Elmhurst, Illinois, 60126, United States
St. Francis Hospital
Evanston, Illinois, 60202, United States
Leonard C. Ferguson Cancer Center
Freeport, Illinois, 61032, United States
Delnor Hospital - Geneva
Geneva, Illinois, 60134, United States
Kellogg Cancer Care Center
Highland Park, Illinois, 60035, United States
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, 60521, United States
Joliet Oncology-Hematology Associates, Limited - West
Joliet, Illinois, 60435, United States
Provena St. Mary's Regional Cancer Center - Kankakee
Kankakee, Illinois, 60901, United States
La Grange Memorial Hospital
La Grange, Illinois, 60525, United States
North Shore Oncology and Hematology Associates, Limited - Libertyville
Libertyville, Illinois, 60048, United States
Cancer Care and Hematology Specialists of Chicagoland - Niles
Niles, Illinois, 60714, United States
West Suburban Center for Cancer Care
River Forest, Illinois, 60305, United States
Swedish-American Regional Cancer Center
Rockford, Illinois, 61104-2315, United States
Center for Cancer Care at OSF Saint Anthony Medical Center
Rockford, Illinois, 61108, United States
Hematology Oncology Associates - Skokie
Skokie, Illinois, 60076, United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801, United States
Central Dupage Cancer Center
Warrenville, Illinois, 60555, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, 46107, United States
Clarian Arnett Cancer Care
Lafayette, Indiana, 47904, United States
Suniti Medical Corporation
Merrillville, Indiana, 46410, United States
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360, United States
Reid Hospital & Health Care Services
Richmond, Indiana, 47374, United States
McFarland Clinic, PC
Ames, Iowa, 50010, United States
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, 52722, United States
Iowa Blood and Cancer Care
Cedar Rapids, Iowa, 52402, United States
St. Luke's Hospital
Cedar Rapids, Iowa, 52402, United States
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, 52403, United States
Mercy Regional Cancer Center at Mercy Medical Center
Cedar Rapids, Iowa, 52403, United States
Medical Oncology and Hematology Associates - West Des Moines
Clive, Iowa, 50325, United States
Mercy Cancer Center - West Lakes
Clive, Iowa, 50325, United States
Heartland Oncology and Hematology
Council Bluffs, Iowa, 51503, United States
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, 50314, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, 50316, United States
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City, Iowa, 50401, United States
McCreery Cancer Center at Ottumwa Regional
Ottumwa, Iowa, 52501, United States
Siouxland Hematology-Oncology Associates, LLP
Sioux City, Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51102, United States
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104, United States
Covenant Cancer Treatment Center
Waterloo, Iowa, 50702, United States
Methodist West Hospital
West Des Moines, Iowa, 50266-7700, United States
Providence Medical Center
Kansas City, Kansas, 66112, United States
Menorah Medical Center
Overland Park, Kansas, 66209, United States
Saint Luke's Hospital - South
Overland Park, Kansas, 66213, United States
CCOP - Kansas City
Prairie Village, Kansas, 66208, United States
Mitchell Memorial Cancer Center at Owensboro Medical Health System
Owensboro, Kentucky, 42303, United States
Mary Bird Perkins Cancer Center - Baton Rouge
Baton Rouge, Louisiana, 70809, United States
Ochsner Health Center - Bluebonnet
Baton Rouge, Louisiana, 70809, United States
Ochsner Health Center - Covington
Covington, Louisiana, 70433, United States
Louisiana State University Health Sciences Center - Monroe
Monroe, Louisiana, 71210, United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112, United States
Medical Center of Louisiana - New Orleans
New Orleans, Louisiana, 70112, United States
New Orleans Cancer Institute at Memorial Medical Center
New Orleans, Louisiana, 70115, United States
CCOP - Ochsner
New Orleans, Louisiana, 70121, United States
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
Feist-Weiller Cancer Center at Louisiana State University Health Sciences
Shreveport, Louisiana, 71130-3932, United States
Harold Alfond Center for Cancer Care
Augusta, Maine, 04330, United States
CancerCare of Maine at Eastern Maine Medical Center
Bangor, Maine, 04401, United States
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
Baltimore, Maryland, 21215, United States
Kaiser Permanente at Woodlawn Medical Center
Baltimore, Maryland, 21244, United States
Regional Cancer Center at Western Maryland Health System - Sacred Heart Campus
Cumberland, Maryland, 21502, United States
Frederick Memorial Hospital Regional Cancer Therapy Center
Frederick, Maryland, 21701, United States
Kaiser Permanente - Gaithersburg Medical Center
Gaithersburg, Maryland, 20879, United States
Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility
Largo, Maryland, 20774, United States
Peninsula Regional Medical Center
Salisbury, Maryland, 21801, United States
Holy Cross Hospital
Silver Spring, Maryland, 20910, United States
Sturdy Memorial Hospital
Attleboro, Massachusetts, 02703, United States
Addison Gilbert Hospital
Gloucester, Massachusetts, 01930, United States
Jordan Hospital Club Cancer Center
Plymouth, Massachusetts, 02360, United States
Baystate Regional Cancer Program at D'Amour Center for Cancer Care
Springfield, Massachusetts, 01199, United States
UMASS Memorial Cancer Center - University Campus
Worcester, Massachusetts, 01655, United States
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, 49221, United States
Saint Joseph Mercy Cancer Center
Ann Arbor, Michigan, 48106-0995, United States
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, 48106, United States
Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn, Michigan, 48123-2500, United States
Green Bay Oncology, Limited - Escanaba
Escanaba, Michigan, 49431, United States
Genesys Hurley Cancer Institute
Flint, Michigan, 48503, United States
Hurley Medical Center
Flint, Michigan, 48503, United States
Genesys Regional Medical Center
Grand Blanc, Michigan, 48439, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, 48236, United States
Dickinson County Healthcare System
Iron Mountain, Michigan, 49801, United States
Foote Memorial Hospital
Jackson, Michigan, 49201, United States
Borgess Medical Center
Kalamazoo, Michigan, 49001, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007-3731, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
Sparrow Regional Cancer Center
Lansing, Michigan, 48912-1811, United States
St. Mary Mercy Hospital
Livonia, Michigan, 48154, United States
Upper Michigan Cancer Center at Marquette General Hospital
Marquette, Michigan, 49855, United States
Community Cancer Center of Monroe
Monroe, Michigan, 48162, United States
Mercy Memorial Hospital - Monroe
Monroe, Michigan, 48162, United States
St. Joseph Mercy Oakland
Pontiac, Michigan, 48341-2985, United States
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, 48060, United States
Seton Cancer Institute at Saint Mary's - Saginaw
Saginaw, Michigan, 48601, United States
St. John Macomb Hospital
Warren, Michigan, 48093, United States
MeritCare Bemidji
Bemidji, Minnesota, 56601, United States
St. Joseph's Medical Center
Brainerd, Minnesota, 56401, United States
Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
Duluth Clinic Cancer Center - Duluth
Duluth, Minnesota, 55805-1983, United States
CCOP - Duluth
Duluth, Minnesota, 55805, United States
Miller - Dwan Medical Center
Duluth, Minnesota, 55805, United States
Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
Mercy and Unity Cancer Center at Unity Hospital
Fridley, Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350, United States
Immanuel St. Joseph's
Mankato, Minnesota, 56002, United States
HealthEast Cancer Care at St. John's Hospital
Maplewood, Minnesota, 55109, United States
Minnesota Oncology - Maplewood
Maplewood, Minnesota, 55109, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, 55415, United States
New Ulm Medical Center
New Ulm, Minnesota, 56073, United States
Humphrey Cancer Center at North Memorial Outpatient Center
Robbinsdale, Minnesota, 55422-2900, United States
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416, United States
Park Nicollet Cancer Center
Saint Louis Park, Minnesota, 55416, United States
Regions Hospital Cancer Care Center
Saint Paul, Minnesota, 55101, United States
United Hospital
Saint Paul, Minnesota, 55102, United States
St. Francis Cancer Center at St. Francis Medical Center
Shakopee, Minnesota, 55379, United States
Lakeview Hospital
Stillwater, Minnesota, 55082, United States
Ridgeview Medical Center
Waconia, Minnesota, 55387, United States
Willmar Cancer Center at Rice Memorial Hospital
Willmar, Minnesota, 56201, United States
Minnesota Oncology - Woodbury
Woodbury, Minnesota, 55125, United States
Regional Cancer Center at Singing River Hospital
Pascagoula, Mississippi, 39581, United States
Central Care Cancer Center at Carrie J. Babb Cancer Center
Bolivar, Missouri, 65613, United States
Skaggs Cancer Center at Skaggs Regional Medical Center
Branson, Missouri, 65616, United States
Southeast Cancer Center
Cape Girardeau, Missouri, 63703, United States
Goldschmidt Cancer Center
Jefferson City, Missouri, 65109, United States
St. John's Regional Medical Center
Joplin, Missouri, 64804, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital
Kansas City, Missouri, 64111, United States
North Kansas City Hospital
Kansas City, Missouri, 64116, United States
Heartland Hematology Oncology Associates, Incorporated
Kansas City, Missouri, 64118, United States
Research Medical Center
Kansas City, Missouri, 64132, United States
Saint Luke's East - Lee's Summit
Lee's Summit, Missouri, 64086, United States
Parvin Radiation Oncology
Liberty, Missouri, 64068, United States
Mercy Clinic Cancer and Hematology - Rolla
Rolla, Missouri, 65401, United States
Phelps County Regional Medical Center
Rolla, Missouri, 65401, United States
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506, United States
Saint Joseph Oncology, Incorporated
Saint Joseph, Missouri, 64507, United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65802, United States
St. John's Regional Health Center
Springfield, Missouri, 65804, United States
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, 65807, United States
St. Anthony's Cancer Center
St Louis, Missouri, 63128, United States
Missouri Baptist Cancer Center
St Louis, Missouri, 63131, United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101, United States
St. Vincent Healthcare Cancer Care Services
Billings, Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, 59102, United States
Billings Clinic - Downtown
Billings, Montana, 59107-7000, United States
Bozeman Deaconess Cancer Center
Bozeman, Montana, 59715, United States
St. James Healthcare Cancer Care
Butte, Montana, 59701, United States
Great Falls Clinic - Main Facility
Great Falls, Montana, 59405, United States
Sletten Cancer Institute at Benefis Healthcare
Great Falls, Montana, 59405, United States
St. Peter's Hospital
Helena, Montana, 59601, United States
Glacier Oncology, PLLC
Kalispell, Montana, 59901, United States
Kalispell Medical Oncology at KRMC
Kalispell, Montana, 59901, United States
Kalispell Regional Medical Center
Kalispell, Montana, 59901, United States
Montana Cancer Specialists at Montana Cancer Center
Missoula, Montana, 59807-7877, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula, Montana, 59807, United States
Good Samaritan Cancer Center at Good Samaritan Hospital
Kearney, Nebraska, 68848-1990, United States
Cancer Resource Center - Lincoln
Lincoln, Nebraska, 68510, United States
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106, United States
Immanuel Medical Center
Omaha, Nebraska, 68122, United States
Alegant Health Cancer Center at Bergan Mercy Medical Center
Omaha, Nebraska, 68124, United States
Lakeside Hospital
Omaha, Nebraska, 68130, United States
Creighton University Medical Center
Omaha, Nebraska, 68131-2197, United States
Renown Institute for Cancer at Renown Regional Medical Center
Reno, Nevada, 89502, United States
Seacoast Cancer Center at Wentworth - Douglass Hospital
Dover, New Hampshire, 03820, United States
Oncology Center at St. Joseph Hospital
Nashua, New Hampshire, 03060, United States
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, 07018-1095, United States
Monmouth Medical Center
Long Branch, New Jersey, 07740-6395, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Marlton, New Jersey, 08053, United States
Carol G. Simon Cancer Center at Morristown Memorial Hospital
Morristown, New Jersey, 07960, United States
UMDNJ University Hospital
Newark, New Jersey, 07103, United States
Newark Beth Israel Medical Center
Newark, New Jersey, 07112, United States
Frederick R. and Betty M. Smith Cancer Treatment Center
Sparta, New Jersey, 07871, United States
Overlook Hospital
Summit, New Jersey, 07901, United States
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
Vineland, New Jersey, 08360, United States
Fox Chase Virtua Health Cancer Program at Virtua West Jersey
Voorhees Township, New Jersey, 08043, United States
Maimonides Cancer Center at Maimonides Medical Center
Brooklyn, New York, 11219, United States
Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
Cooperstown, New York, 13326, United States
Charles R. Wood Cancer Center at Glens Falls Hospital
Glens Falls, New York, 12801, United States
Nalitt Cancer Institute at Staten Island University Hospital
Staten Island, New York, 10305, United States
Stony Brook University Cancer Center
Stony Brook, New York, 11794-9446, United States
Albert Einstein Cancer Center at Albert Einstein College of Medicine
The Bronx, New York, 10461, United States
Faxton Regional Cancer Center
Utica, New York, 13502, United States
Dickstein Cancer Treatment Center at White Plains Hospital Center
White Plains, New York, 10601, United States
Randolph Hospital
Asheboro, North Carolina, 27203-5400, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, 27599-7295, United States
Presbyterian Cancer Center at Presbyterian Hospital
Charlotte, North Carolina, 28233-3549, United States
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, 27534, United States
Moses Cone Regional Cancer Center at Wesley Long Community Hospital
Greensboro, North Carolina, 27403-1198, United States
Pardee Memorial Hospital
Hendersonville, North Carolina, 28791, United States
Kinston Medical Specialists
Kinston, North Carolina, 28501, United States
Annie Penn Cancer Center
Reidsville, North Carolina, 27320, United States
Rutherford Hospital
Rutherfordton, North Carolina, 28139, United States
Iredell Memorial Hospital
Statesville, North Carolina, 28677, United States
Medcenter One Hospital Cancer Care Center
Bismarck, North Dakota, 58501, United States
Mid Dakota Clinic, PC
Bismarck, North Dakota, 58501, United States
St. Alexius Medical Center Cancer Center
Bismarck, North Dakota, 58502, United States
MeritCare Broadway
Fargo, North Dakota, 58102, United States
Dakota Cancer Institute at Dakota Clinic - South University
Fargo, North Dakota, 58103, United States
CCOP - MeritCare Hospital
Fargo, North Dakota, 58122, United States
Roger Maris Cancer Center at MeritCare Hospital
Fargo, North Dakota, 58122, United States
Altru Cancer Center at Altru Hospital
Grand Forks, North Dakota, 58201, United States
Trinity CancerCare Center
Minot, North Dakota, 58701, United States
Cleveland Clinic Beachwood Family Health and Surgery Center
Beachwood, Ohio, 44122, United States
Wood County Oncology Center
Bowling Green, Ohio, 43402, United States
Mercy Cancer Center at Mercy Medical Center
Canton, Ohio, 44708, United States
Aultman Cancer Center at Aultman Hospital
Canton, Ohio, 44710-1799, United States
Case Comprehensive Cancer Center
Cleveland, Ohio, 44106-5065, United States
MetroHealth Cancer Care Center at MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland, Ohio, 44111, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
Grandview Hospital
Dayton, Ohio, 45405, United States
Good Samaritan Hospital
Dayton, Ohio, 45406, United States
David L. Rike Cancer Center at Miami Valley Hospital
Dayton, Ohio, 45409, United States
Samaritan North Cancer Care Center
Dayton, Ohio, 45415, United States
CCOP - Dayton
Dayton, Ohio, 45420, United States
Community Cancer Center
Elyria, Ohio, 44035, United States
Hematology Oncology Center
Elyria, Ohio, 44035, United States
Blanchard Valley Medical Associates
Findlay, Ohio, 45840, United States
Middletown Regional Hospital
Franklin, Ohio, 45005-1066, United States
Wayne Hospital
Greenville, Ohio, 45331, United States
Cleveland Clinic Cancer Center
Independence, Ohio, 44131, United States
Charles F. Kettering Memorial Hospital
Kettering, Ohio, 45429, United States
St. Rita's Medical Center
Lima, Ohio, 45801, United States
Lima Memorial Hospital
Lima, Ohio, 45804, United States
Northwest Ohio Oncology Center
Maumee, Ohio, 43537-1839, United States
Hillcrest Cancer Center at Hillcrest Hospital
Mayfield Heights, Ohio, 44124, United States
Southwest General Health Center
Middleburg Heights, Ohio, 44130, United States
UHHS Chagrin Highlands Medical Center
Orange, Ohio, 44122, United States
St. Charles Mercy Hospital
Oregon, Ohio, 43616, United States
Toledo Clinic - Oregon
Oregon, Ohio, 43616, United States
Parma Community General Hospital
Parma, Ohio, 44129, United States
North Coast Cancer Care, Incorporated
Sandusky, Ohio, 44870, United States
Cleveland Clinic Foundation - Strongsville
Strongsville, Ohio, 44136, United States
Flower Hospital Cancer Center
Sylvania, Ohio, 43560, United States
Mercy Hospital of Tiffin
Tiffin, Ohio, 44883, United States
Toledo Hospital
Toledo, Ohio, 43606, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Medical University of Ohio Cancer Center
Toledo, Ohio, 43614, United States
CCOP - Toledo Community Hospital
Toledo, Ohio, 43617, United States
St. Anne Mercy Hospital
Toledo, Ohio, 43623, United States
Toledo Clinic, Incorporated - Main Clinic
Toledo, Ohio, 43623, United States
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, 45373-1300, United States
Fulton County Health Center
Wauseon, Ohio, 43567, United States
UHHS Westlake Medical Center
Westlake, Ohio, 44145, United States
Cleveland Clinic - Wooster
Wooster, Ohio, 44691, United States
United States Air Force Medical Center - Wright-Patterson
Wright-Patterson Air Force Base, Ohio, 45433-5529, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, 45385, United States
Cancer Care Associates - Norman
Norman, Oklahoma, 73071, United States
Cancer Care Associates - Mercy Campus
Oklahoma City, Oklahoma, 73120, United States
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, 74136, United States
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
Allentown, Pennsylvania, 18105, United States
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, 19010, United States
Geisinger Cancer Institute at Geisinger Health
Danville, Pennsylvania, 17822-0001, United States
Mercy Fitzgerald Hospital
Darby, Pennsylvania, 19023, United States
Ephrata Cancer Center at Ephrata Community Hospital
Ephrata, Pennsylvania, 17522, United States
Regional Cancer Center - Erie
Erie, Pennsylvania, 16505, United States
Fox Chase Cancer Center Buckingham
Furlong, Pennsylvania, 18925, United States
Adams Cancer Center
Gettysburg, Pennsylvania, 17325, United States
Cherry Tree Cancer Center
Hanover, Pennsylvania, 17331, United States
PinnacleHealth Regional Cancer Center at Polyclinic Hospital
Harrisburg, Pennsylvania, 17110-2098, United States
Geisinger Hazleton Cancer Center
Hazleton, Pennsylvania, 18201, United States
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850, United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17604, United States
Lewistown Hospital
Lewistown, Pennsylvania, 17044, United States
Riddle Memorial Hospital Cancer Center
Media, Pennsylvania, 19063, United States
Cancer Center of Paoli Memorial Hospital
Paoli, Pennsylvania, 19301-1792, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, 19107-5541, United States
Fox Chase Cancer Center - Philadelphia
Philadelphia, Pennsylvania, 19111-2497, United States
Frankford Hospital Cancer Center - Torresdale Campus
Philadelphia, Pennsylvania, 19114, United States
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, 19141, United States
Iris V. Henderson Cancer Center at Mercy Hospital of Philadelphia
Philadelphia, Pennsylvania, 19143, United States
St. Joseph Medical Center
Reading, Pennsylvania, 19605, United States
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
Reading, Pennsylvania, 19612-6052, United States
Guthrie Cancer Center at Guthrie Clinic Sayre
Sayre, Pennsylvania, 18840, United States
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, 18501, United States
Hematology and Oncology Associates of Northeastern Pennsylvania
Scranton, Pennsylvania, 18510, United States
Grand View Hospital
Sellersville, Pennsylvania, 18960, United States
Geisinger Medical Group - Scenery Park
State College, Pennsylvania, 16801, United States
Mount Nittany Medical Center
State College, Pennsylvania, 16803, United States
Chester County Hospital
West Chester, Pennsylvania, 19380, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, 18711, United States
Susquehanna Cancer Center at Divine Providence Hospital
Williamsport, Pennsylvania, 17701, United States
CCOP - Main Line Health
Wynnewood, Pennsylvania, 19096, United States
Lankenau Cancer Center at Lankenau Hospital
Wynnewood, Pennsylvania, 19096, United States
York Cancer Center at Apple Hill Medical Center
York, Pennsylvania, 17405, United States
AnMed Cancer Center
Anderson, South Carolina, 29621, United States
Cancer Centers of the Carolinas - Easley
Easley, South Carolina, 29640, United States
Bon Secours St. Francis Health System
Greenville, South Carolina, 29601, United States
Cancer Centers of the Carolinas - Faris Road
Greenville, South Carolina, 29605, United States
Cancer Centers of the Carolinas - Grove Commons
Greenville, South Carolina, 29605, United States
Greenville Hospital Cancer Center
Greenville, South Carolina, 29605, United States
CCOP - Greenville
Greenville, South Carolina, 29615, United States
Cancer Centers of the Carolinas - Greer Medical Oncology
Greer, South Carolina, 29650, United States
Cancer Centers of the Carolinas - Seneca
Seneca, South Carolina, 29672, United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg, South Carolina, 29303, United States
Cancer Centers of the Carolinas - Spartanburg
Spartanburg, South Carolina, 29307, United States
Oncology Services of Aberdeen
Aberdeen, South Dakota, 57401, United States
Rapid City Regional Hospital
Rapid City, South Dakota, 57701, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
Sanford Cancer Center at Sanford USD Medical Center
Sioux Falls, South Dakota, 57117-5039, United States
West Tennessee Cancer Center at Jackson-Madison County General Hospital
Jackson, Tennessee, 38301, United States
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
Kingsport, Tennessee, 37662, United States
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232-6838, United States
Hendrick Cancer Center
Abilene, Texas, 79601, United States
Harrington Cancer Center
Amarillo, Texas, 79106, United States
M. D. Anderson Cancer Center at University of Texas
Houston, Texas, 77030-4009, United States
Community Cancer Center at Rutland Regional Medical Center
Rutland, Vermont, 05701, United States
Fredericksburg Oncology, Incorporated
Fredericksburg, Virginia, 22401, United States
Virginia Oncology Associates - Hampton
Hampton, Virginia, 23666, United States
Kaiser Permanente Tysons Corner Medical Center
McLean, Virginia, 22102, United States
Southwest Virginia Regional Cancer Center at Wellmonth Health
Norton, Virginia, 24273, United States
Virginia Commonwealth University Massey Cancer Center
Richmond, Virginia, 23298-0037, United States
Auburn Regional Center for Cancer Care
Auburn, Washington, 98002, United States
Overlake Cancer Center at Overlake Hospital Medical Center
Bellevue, Washington, 98004, United States
Providence Centralia Hospital
Centralia, Washington, 98531-9027, United States
Providence Regional Cancer Partnership
Everett, Washington, 98201, United States
St. Francis Hospital
Federal Way, Washington, 98003, United States
Cascade Cancer Center at Evergreen Hospital Medical Center
Kirkland, Washington, 98033, United States
Providence St. Peter Hospital Regional Cancer Center
Olympia, Washington, 98506-5166, United States
Good Samaritan Cancer Center
Puyallup, Washington, 98372, United States
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101, United States
Virginia Mason Medical Center
Seattle, Washington, 98101, United States
Pacific Medical Center
Seattle, Washington, 98104, United States
Rockwood Clinic Cancer Treatment Center
Spokane, Washington, 99204-2967, United States
Franciscan Cancer Center at St. Joseph Medical Center
Tacoma, Washington, 98405-3004, United States
Allenmore Hospital
Tacoma, Washington, 98405, United States
CCOP - Northwest
Tacoma, Washington, 98405, United States
MultiCare Regional Cancer Center at Tacoma General Hospital
Tacoma, Washington, 98405, United States
St. Clare Hospital
Tacoma, Washington, 98499, United States
West Virginia University Health Sciences Center - Charleston
Charleston, West Virginia, 25304, United States
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
Morgantown, West Virginia, 26506, United States
Langlade Memorial Hospital
Antigo, Wisconsin, 54409, United States
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54301-3526, United States
Bellin Memorial Hospital
Green Bay, Wisconsin, 54301, United States
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay, Wisconsin, 54303, United States
St. Mary's Hospital Medical Center - Green Bay
Green Bay, Wisconsin, 54303, United States
St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54307-3508, United States
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311, United States
Mercy Regional Cancer Center
Janesville, Wisconsin, 53547, United States
Gundersen Lutheran Center for Cancer and Blood
La Crosse, Wisconsin, 54601, United States
Holy Family Memorial Medical Center Cancer Care Center
Manitowoc, Wisconsin, 54221-1450, United States
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, 54143, United States
Vince Lombardi Cancer Clinic - Marinette
Marinette, Wisconsin, 54143, United States
Wheaton Franciscan Cancer Care - St. Joseph
Milwaukee, Wisconsin, 53210, United States
D.N. Greenwald Center
Mukwonago, Wisconsin, 53149, United States
Regional Cancer Center at Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066, United States
Green Bay Oncology, Limited - Oconto Falls
Oconto Falls, Wisconsin, 54154, United States
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904, United States
St. Nicholas Hospital
Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic - Sheboygan
Sheboygan, Wisconsin, 53081, United States
Green Bay Oncology, Limited - Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235, United States
Aurora Medical Center
Summit, Wisconsin, 53066, United States
Vince Lombardi Cancer Clinic - Two Rivers
Two Rivers, Wisconsin, 54241, United States
Waukesha Memorial Hospital Regional Cancer Center
Waukesha, Wisconsin, 53188, United States
University of Wisconcin Cancer Center at Aspirus Wausau Hospital
Wausau, Wisconsin, 54401, United States
Oncology Alliance, SC - Milwaukee - West
Wauwatosa, Wisconsin, 53226, United States
Riverview UW Cancer Center at Riverview Hospital
Wisconsin Rapids, Wisconsin, 54494, United States
Rocky Mountain Oncology
Casper, Wyoming, 82609, United States
Related Publications (1)
Ramalingam SS, Dahlberg SE, Belani CP, Saltzman JN, Pennell NA, Nambudiri GS, McCann JC, Winegarden JD, Kassem MA, Mohamed MK, Rothman JM, Lyss AP, Horn L, Stinchcombe TE, Schiller JH. Pemetrexed, Bevacizumab, or the Combination As Maintenance Therapy for Advanced Nonsquamous Non-Small-Cell Lung Cancer: ECOG-ACRIN 5508. J Clin Oncol. 2019 Sep 10;37(26):2360-2367. doi: 10.1200/JCO.19.01006. Epub 2019 Jul 30.
PMID: 31361535RESULT
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Study Statistician
- Organization
- ECOG-ACRIN Biostatistics Center
Study Officials
- STUDY CHAIR
Suresh Ramalingam, MD
Emory University
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- LTE60
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 20, 2010
First Posted
April 21, 2010
Study Start
October 25, 2010
Primary Completion
January 31, 2019
Study Completion
August 17, 2021
Last Updated
July 7, 2023
Results First Posted
February 23, 2021
Record last verified: 2023-06
Data Sharing
- IPD Sharing
- Will share
Individual participant data may be made available upon request as per the ECOG-ACRIN Data Sharing Policy.