Effects of Docosahexaenoic Acid (DHA)-Rich Fish Oil on Cerebral Haemodynamics
The Cognitive And Cerebral Hemodynamic Effects Of DHA-Rich Fish Oil: A Dose-Ranging Study
1 other identifier
interventional
65
1 country
1
Brief Summary
DHA has previously been shown to increase regional cerebral blood flow response to tactile stimulation in aged monkeys; modulation of cerebral blood flow in humans has yet to be demonstrated. Given that the brain relies on a constant supply of blood-borne metabolic substrates (e.g. glucose, oxygen), increasing regional cerebral blood flow may also have an impact on cognitive function. The current study aims to investigate the effects of two doses of DHA-rich fish oil on task-related cerebral hemodynamic response and cognitive performance in healthy adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Apr 2009
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2009
CompletedFirst Submitted
Initial submission to the registry
February 24, 2010
CompletedFirst Posted
Study publicly available on registry
February 25, 2010
CompletedFebruary 25, 2010
February 1, 2010
1 month
February 24, 2010
February 24, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cerebral blood flow
Cerebral blood flow will be assessed using Near Infrared Spectroscopy while participants complete a series of cognitive tasks.
12 weeks
Secondary Outcomes (1)
Cognitive function
12 weeks
Study Arms (3)
1 g DHA-rich fish oil
ACTIVE COMPARATOR1 g DHA-rich fish oil containing 450 mg DHA + 90 mg EPA plus 1 g olive oil
2 g DHA-rich fish oil
ACTIVE COMPARATOR2 g DHA-rich fish oil containing 900 mg DHA + 180 mg EPA
Placebo
PLACEBO COMPARATOR2 g olive oil
Interventions
Either 1 g or 2 g DHA-rich fish oil taken daily for 12 weeks. Participants in the 1 g group will also consume 1 g olive oil placebo capsules per day to maintain double blind.
Eligibility Criteria
You may qualify if:
- Male/Female
- years
- Healthy
- No herbal supplements/prescription medications (excl. contraceptive pill)
- Non smoker
- Native English speaker
You may not qualify if:
- consumes oily fish
- takes omega-3 supplement
- food allergies to treatment ingredients
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Northumbria Universitylead
- Ginsana SAcollaborator
Study Sites (1)
Northumbria University
Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom
Related Publications (1)
Jackson PA, Reay JL, Scholey AB, Kennedy DO. Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. Biol Psychol. 2012 Jan;89(1):183-90. doi: 10.1016/j.biopsycho.2011.10.006. Epub 2011 Oct 19.
PMID: 22020134DERIVED
Related Links
Study Officials
- PRINCIPAL INVESTIGATOR
Philippa A Jackson
Northumbria University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
February 24, 2010
First Posted
February 25, 2010
Study Start
April 1, 2009
Primary Completion
May 1, 2009
Study Completion
August 1, 2009
Last Updated
February 25, 2010
Record last verified: 2010-02