Cognitive and Mood Effects of Docosahexaenoic Acid (DHA)-Rich and Eicosapentaenoic Acid (EPA)-Rich Fish Oil in Healthy Young Adults
1 other identifier
interventional
159
1 country
1
Brief Summary
To date, only a small handful of studies have assessed the effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cognitive function in healthy adults. The results from these studies are mixed, and have differed greatly in terms of methodology as regards sample size, treatment formulation and duration of the intervention. In order to address these issues, the present study aims to assess the effects of two different formulations of fish oil in parallel, and at doses consistent with the current recommended daily intake of oily fish, across a range of cognitive domains. The aim of the present investigation is therefore to specifically evaluate the effects of 12 weeks supplementation of DHA-rich fish oil and EPA-rich fish oil dietary supplements on cognitive function in healthy young adults maintaining a regular diet containing oily fish not more than once a week. Self-report mood assessments will form the secondary part of this investigation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Dec 2007
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2008
CompletedFirst Submitted
Initial submission to the registry
February 24, 2010
CompletedFirst Posted
Study publicly available on registry
February 25, 2010
CompletedFebruary 25, 2010
February 1, 2010
1 year
February 24, 2010
February 24, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cognitive performance
Performance is assessed using the COMPASS (Computerised Mental Performance Assessment) system, which presents a battery of standard cognitive tasks assessing aspects of attention, memory and executive function. The Cognitive Demand Battery (30 minutes)will also be administered and assesses cognitive performance under mental fatigue.
12 weeks
Secondary Outcomes (1)
Mood
12 weeks
Study Arms (3)
DHA-rich fish oil
ACTIVE COMPARATOR1 g DHA-rich fish oil containing 450 mg DHA + 90 mg EPA
EPA-rich fish oil
ACTIVE COMPARATOR1 g EPA-rich fish oil containing 300 mg EPA + 200 mg DHA
Placebo
PLACEBO COMPARATOR1 g Olive oil
Interventions
Eligibility Criteria
You may qualify if:
- Male/Female
- years
- Healthy
- No herbal supplements/prescription medications (excl. contraceptive pill)
- Non smoker
- Native English speaker
You may not qualify if:
- Consumes ≥ 1 portion oily fish/week
- takes omega-3 supplement
- Food allergies to treatment ingredients
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Northumbria Universitylead
- Ginsana SAcollaborator
Study Sites (1)
Northumbria University
Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom
Related Links
Study Officials
- PRINCIPAL INVESTIGATOR
Philippa A Jackson
Northumbria University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
February 24, 2010
First Posted
February 25, 2010
Study Start
December 1, 2007
Primary Completion
December 1, 2008
Study Completion
December 1, 2008
Last Updated
February 25, 2010
Record last verified: 2010-02