Cognitive Effects of 500mg Trans-resveratrol

NCT01794351 | Completed

• 1 other identifier: 22P5
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigated the potentially cognitive enhancing effects of 500mg trans-resveratrol in healthy, young humans.

Conditions

Cognitive Performance; Mood

Outcome Measures

Primary Outcomes (4)

• Number of participants with altered cognitive function at 40mins post-dose

  This outcome measure is assessed by the number of participants whose scores on a range of cognitive tasks (word and picture recall and recognition, serial 3s and 7s subtractions, rapid visual information processing (RVIP), N-Back (3-Back version), Stroop and numeric working memory) differed from the baseline to 40min post-dose scores.

  40mins Post-dose

• Number of participants with altered cognitive function at 2.5hrs post-dose

  This outcome measure is assessed by the number of participants whose scores on a range of cognitive tasks (word and picture recall and recognition, serial 3s and 7s subtractions, rapid visual information processing (RVIP), N-Back (3-Back version), Stroop and numeric working memory) differed from baseline to the 2.5hr post-dose scores.

  2.5hrs post-dose

• Number of participants with altered cognitive function at 4hrs post-dose

  This outcome measure is assessed by the number of participants whose scores on a range of cognitive tasks (word and picture recall and recognition, serial 3s and 7s subtractions, rapid visual information processing (RVIP), N-Back (3-Back version), Stroop and numeric working memory) differed from baseline to the 4hr post-dose scores.

  4hrs post-dose

• Number of participants with altered cognitive function at 6hrs post-dose

  This outcome measure is assessed by the number of participants whose scores on a range of cognitive tasks (word and picture recall and recognition, serial 3s and 7s subtractions, rapid visual information processing (RVIP), N-Back (3-Back version), Stroop and numeric working memory) differed from baseline to the 6hr post-dose scores.

  6hrs post-dose

Secondary Outcomes (4)

• Number of participants with altered mood at 40mins post-dose.

  40mins post-dose

• Number of participants with altered mood at 2.5hrs post-dose

  2.5hrs post-dose

• Number of participants with altered mood at 4hrs post-dose

  4hrs pos-dose

• Number of participants with altered mood at 6hrs post-dose

  6hrs post-dose

Study Arms (2)

Placebo then resveratrol

EXPERIMENTAL

Participants in this arm (decided according to Latin square) first received placebo and then resveratrol, on seperate days, with a 7-14 day wash-out period between visits.

Dietary Supplement: Trans-resveratrol; Other: Placebo

Resveratrol then placebo

EXPERIMENTAL

Participants in this arm (decided according to Latin square) first received resveratrol and then placebo, on seperate days, with a 7-14 day wash-out period between visits

Dietary Supplement: Trans-resveratrol; Other: Placebo

Interventions

Trans-resveratrol DIETARY_SUPPLEMENT

In this crossoevr study, all participants also consumed 500mg trans-resveratrol (in 2 opaque vegetarian capsules), at baseline, on counterballanced days.

Placebo then resveratrol; Resveratrol then placebo

Placebo OTHER

In this crossoevr study, all participants also consumed placebo (2 opaque vegetarian capsules), at baseline, on counterballanced days.

Also known as: Pharmaceutical grade silica

Placebo then resveratrol; Resveratrol then placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• yrs, healthy.

You may not qualify if:

• Drug/alcohol abuse, taking prescription medication (apart from contraception) or herbal supplements, having food intolerances or allergies, having suffered a head-injury or neurological/neuro-developmental disorder, uncorrected sight problems, pregnant or seeking to become so, excessive caffeine use (e.g. more than 6 cups of coffee per day).

Sponsors & Collaborators

• Northumbria University: lead

Study Sites (1)

Brain performance and nutrition research centre, Northumbria university

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

Location

MeSH Terms

Interventions

Resveratrol

Intervention Hierarchy (Ancestors)

Stilbestrols; Stilbenes; Benzylidene Compounds; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Polyphenols; Phenols

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 8, 2013
• First Posted: February 18, 2013
• Study Start: October 1, 2012
• Primary Completion: December 1, 2012
• Study Completion: December 1, 2012
• Last Updated: February 18, 2013

Record last verified: 2013-02

Locations

GB (1)