Functional Neuroimaging of Cortical Plasticity in the Human Visual System

NCT01062672 | Withdrawn

• 1 other identifier: H--22516
• Study Type: observational
• Target: N/A
• Locations: 2 countries
• Sites: 2

Brief Summary

The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways. Subjects with retinal or cortical injury will be studied and compared to appropriate controls. Functional magnetic resonance imaging methods are used to monitor cortical topography in time. The main aims of the study are to determine: 1) what are the patterns of cortical reorganization that are seen spontaneously after injury, and 2) whether rehabilitative training can promote adaptive reorganization enhancing recovery.

Conditions

Stroke; Blindness; Vision

Keywords

plasticity; reorganization; cortical; fMRI; rehabilitation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with lesions of the visual pathway (cortical or retinal)

You may qualify if:

• Stable lesion of the visual pathways resulting in a visual field scotoma.

You may not qualify if:

• Inability to undergo magnetic resonance imaging,
• Inability to comply with basic instructions,
• Inability to perform the behavioral tasks required,
• Patients with chronic progressive neurological or psychiatric disorders,
• Patients that are pregnant, or breast feeding.

Sponsors & Collaborators

• Baylor College of Medicine: lead
• Brigham and Women's Hospital: collaborator

Study Sites (2)

Baylor College of Medicine

Houston, Texas, 77030, United States

Location

Max Planck Institute for Biological Cybernetics

Tübingen, Germany

Location

MeSH Terms

Conditions

Stroke; Blindness

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Vision Disorders; Sensation Disorders; Neurologic Manifestations; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 3, 2010
• First Posted: February 4, 2010
• Study Start: January 1, 2009
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: April 11, 2022

Record last verified: 2022-04

Locations

DE (1); US (1)