Association Between Breastfeeding and Likelihood of Myopia in 6-7 Years Old Children

NCT01013493 | Completed DMC

• 1 other identifier: 292
• Study Type: observational
• Target: 245
• Locations: 1 country
• Sites: 1

Brief Summary

Myopia is the main reason of vision loss in the world which is seen in 30.4 million adults in USA (1). In a myopic eye, images are focused in front of retina because, cornea and crystalline lens become more powerful in focusing the image or the eye axis become too long (axial myopia) (2). Myopia prevalence in adolescents has been raised in recent years and nowadays it has reached to 10-25% and 60-80% in western and eastern countries respectively (3). Tehran eye study showed that the prevalence of myopia in Tehran is 21.8% and 17.2% based on manifest and cycloplegic refraction respectively (4). One study in Dezful, Iran showed that 3.7% of 7-15 years old children are myopic (5). Today potential role of early life nutrition in myopia development in later life is becoming an attractive field of study. It has been shown that until weaning; breast milk is the main source of many nutrients \[such as docosahexaenoic acid (DHA)\] which are important for photoreceptors and cortical neuronal development (6). But results about the relationship between breastfeeding and likelihood of childhood myopia are controversial. A hypothesis-generating study (7) showed an independent and inverse relationship between breastfeeding and likelihood of myopia in 10-12 year old Singaporean children. However, data pulled from three English birth cohorts done in 10-11y and 15-16y children did not show any effect (8). To examine the association between breastfeeding pattern and likelihood of myopia in 6-7y children, a retrospective case-control study is designed in National Nutrition and Food Technology research Institute of Iran. This study will try to assess breastfeeding pattern and almost all cofactors which may relate to myopia.

Conditions

Myopia; Nearsightedness

Keywords

breastfeeding; myopia; nearsightedness; children

Study Arms (2)

myopic

non myope-healthy

Eligibility Criteria

• Age: 6 Years - 7 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

This study is a retrospective case-control trial, in which subjects for case and control groups will be chosen based on inclusion and exclusion criteria, from 6-7 years old school children living in north Tehran.

You may qualify if:

• Subjects must be 6-7 years old
• Subjects must have myopia with or without astigmatism and the time period between diagnosis of myopia and recruiting the subjects must not be more than 6 months.
• Subject must be graduating in grade 1 in one of north Tehran elementary schools.
• Subject and their parents must have tendency to participate in this study.
• Subjects must be 6-7 years old
• Subjects must graduate in grade, class and elementary school which case subjects is graduating in.

You may not qualify if:

• Subjects must not have any eye disorder other than myopia with or without astigmatism
• Subjects must not have any metabolic or congenital disorder which has relationship with myopia.
• Subjects must not have any eye disorder
• Subjects must not have any metabolic or congenital disorder which has relationship with myopia.
• Subjects must not go on diet for any reason.

Sponsors & Collaborators

• National Nutrition and Food Technology Institute: lead

Study Sites (1)

National Nutrition and Food Technology Research Institute (NNFTRI)

Tehran, Tehran Province, 1981619573, Iran

Location

MeSH Terms

Conditions

Myopia; Breast Feeding

Condition Hierarchy (Ancestors)

Refractive Errors; Eye Diseases; Feeding Behavior; Behavior

Study Officials

• Amin Salehi Abargouei, M.S

  Faculty of Nutrition Sciences and Food Technology, Sh. Beheshti University of Medical Sciences and Health Services, Tehran, Iran

  PRINCIPAL INVESTIGATOR

• Naser Kalantari, Pediatrist

  Faculty of Nutrition Sciences and Food Technology, Sh. Beheshti University of Medical Sciences and Health Services, Tehran, Iran

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 12, 2009
• First Posted: November 13, 2009
• Study Start: September 1, 2008
• Primary Completion: March 1, 2009
• Study Completion: June 1, 2009
• Last Updated: December 2, 2009

Record last verified: 2009-12

Locations

IR (1)