Clinical and Genetic Studies in Families With Myopia and Related Diseases

NCT00272376 | Completed

• 2 other identifiers: 06005806-EI-0058
• Study Type: observational
• Target: 851
• Locations: 2 countries
• Sites: 2

Brief Summary

This study will examine the inheritance of myopia in families of various nationalities and ethnic backgrounds to identify gene changes that cause myopia or similar diseases and to better understand these conditions. In patients with myopia, the eye does not focus light accurately on the retina (tissue that lines the back of the eye), so that objects at a distance appear blurry. Myopia may occur alone, with other vision problems such as retinal dislocations, cataract or glaucoma, or with other problems such as joint or skin problems. People with myopia (usually those from families with several affected members) and control subjects with normal vision may be eligible for this study. Each participant undergoes the following procedures:

• Blood draw for genetic testing related to the disorders under study
• Medical and family history, including drawing a family tree to explore vision problems in the family
• Complete eye examination, including refraction (pupil dilation) and visual acuity testing, photographs of the retina and possibly lens, and specialized tests to measure field of vision, color vision and ability to see in the dark

Conditions

Myopia

Keywords

Myopia; Nearsightedness

Outcome Measures

Primary Outcomes (1)

• Statistically significant linkage

Eligibility Criteria

• Age: 4 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals or family members of individuals with myopia, either congenital, childhood, or older.
• Adults must be capable of providing their own consent.
• All subjects must be able to cooperate with study examination and phlebotomy.
• Older than 4 years of age.

You may not qualify if:

• Diseases, infections, or trauma that mimic primary myopia.
• Children requiring sedation for study procedures.

Sponsors & Collaborators

• National Eye Institute (NEI): lead

Study Sites (2)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Zhongshan Ophthalmic Center, Sun Yat-sen University

Guangzho, China

Location

Related Publications (3)

• Mutti DO, Mitchell GL, Moeschberger ML, Jones LA, Zadnik K. Parental myopia, near work, school achievement, and children's refractive error. Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3633-40.

  PMID: 12454029 BACKGROUND

• Teikari JM, O'Donnell J, Kaprio J, Koskenvuo M. Impact of heredity in myopia. Hum Hered. 1991;41(3):151-6. doi: 10.1159/000153994.

  PMID: 1937488 BACKGROUND

• Zhang Q, Guo X, Xiao X, Yi J, Jia X, Hejtmancik JF. Clinical description and genome wide linkage study of Y-sutural cataract and myopia in a Chinese family. Mol Vis. 2004 Nov 17;10:890-900.

  PMID: 15570218 BACKGROUND

MeSH Terms

Conditions

Myopia

Condition Hierarchy (Ancestors)

Refractive Errors; Eye Diseases

Study Officials

• James F Hejtmancik, M.D.

  National Eye Institute (NEI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2006
• First Posted: January 5, 2006
• Study Start: December 21, 2005
• Study Completion: July 29, 2016
• Last Updated: December 12, 2019

Record last verified: 2016-07-29

Locations

US (1); CN (1)