NCT00272376|Completed
Clinical and Genetic Studies in Families With Myopia and Related Diseases
Clinical and Molecular Studies in Families With Myopia and Related Diseases
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Clinical and Molecular Studies in Families With Myopia and Related Diseases
Sponsor study identifier
Secondary identifiers
observational
851
2 countries
2
Study Start
December 21, 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
July 29, 2016
Date type not reportedThis date has not been verified as actual or estimated.
This study will examine the inheritance of myopia in families of various nationalities and ethnic backgrounds to identify gene changes that cause myopia or similar diseases and to better understand these conditions. In patients with myopia, the eye does not focus light accurately on the retina (tissue that lines the back of the eye), so that objects at a distance appear blurry. Myopia may occur alone, with other vision problems such as retinal dislocations, cataract or glaucoma, or with other problems such as joint or skin problems. People with myopia (usually those from families with several affected members) and control subjects with normal vision may be eligible for this study. Each participant undergoes the following procedures:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 29, 2016
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 21, 2005
Date type not reportedThis date has not been verified as actual or estimated.
January 5, 2006
Actual (reported)January 5, 2006
Actual (reported)July 29, 2016
Date type not reportedThis date has not been verified as actual or estimated.
Statistically significant linkage
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzho, China
Mutti DO, Mitchell GL, Moeschberger ML, Jones LA, Zadnik K. Parental myopia, near work, school achievement, and children's refractive error. Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3633-40.
Teikari JM, O'Donnell J, Kaprio J, Koskenvuo M. Impact of heredity in myopia. Hum Hered. 1991;41(3):151-6. doi: 10.1159/000153994.
Zhang Q, Guo X, Xiao X, Yi J, Jia X, Hejtmancik JF. Clinical description and genome wide linkage study of Y-sutural cataract and myopia in a Chinese family. Mol Vis. 2004 Nov 17;10:890-900.
James F Hejtmancik, M.D.
National Eye Institute (NEI)
851 participants (actual enrollment reported by the registry).
First Submitted
January 5, 2006
First Posted
January 5, 2006
Study Start
December 21, 2005
Date type not reportedThis date has not been verified as actual or estimated.
Controlling Myopia Progression With Soft Contact Lenses
Contact the study team to confirm eligibility.
Study Completion
July 29, 2016
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
December 12, 2019
Record last verified: 2016-07-29
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Source: ClinicalTrials.gov.
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