NCT00985699

Brief Summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
337

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2009

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2009

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

September 25, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 28, 2009

Completed
4.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2014

Completed
Last Updated

July 24, 2014

Status Verified

July 1, 2014

Enrollment Period

5.2 years

First QC Date

September 25, 2009

Last Update Submit

July 23, 2014

Conditions

Lymphoma

Keywords

non-Hodgkin lymphomacutaneous B-cell non-Hodgkin lymphomaextranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissuenodal marginal zone B-cell lymphoma

Outcome Measures

Primary Outcomes (2)

  • Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival

    retrospectively

  • Association of polymorphisms in these genes with rate of grade 4-5 hematologic toxicity

    retrospectively

Interventions

polymorphism analysisGENETIC
laboratory biomarker analysisOTHER
pharmacogenomic studiesOTHER

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients enrolled on S8516 S8736 S9125 S9240 consenting to banking

DISEASE CHARACTERISTICS: * Diagnosis of aggressive B-cell non-Hodgkin lymphoma * Previously treated with curative intent using anthracycline-based therapies * Previously collected paraffin-embedded diagnostic tissues from clinical trials that were collected as part of SWOG treatment protocols (S8516, S8736, S9125, S9240, and S9349) available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * See Disease Characteristics

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

MeSH Terms

Conditions

LymphomaLymphoma, Non-HodgkinLymphoma, B-Cell, Marginal Zone

Interventions

Amplified Fragment Length Polymorphism AnalysisPharmacogenomic Testing

Condition Hierarchy (Ancestors)

Neoplasms by Histologic TypeNeoplasmsLymphoproliferative DisordersLymphatic DiseasesHemic and Lymphatic DiseasesImmunoproliferative DisordersImmune System DiseasesLymphoma, B-Cell

Intervention Hierarchy (Ancestors)

DNA FingerprintingGenetic TechniquesInvestigative TechniquesPolymerase Chain ReactionNucleic Acid Amplification TechniquesGenetic TestingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisGenetic ServicesHealth ServicesHealth Care Facilities Workforce and ServicesDiagnostic ServicesPreventive Health Services

Study Officials

  • Margaret M. Briehl, PhD

    University of Arizona

    STUDY CHAIR

Study Design

Study Type
observational
Time Perspective
RETROSPECTIVE
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 25, 2009

First Posted

September 28, 2009

Study Start

April 1, 2009

Primary Completion

June 1, 2014

Study Completion

June 1, 2014

Last Updated

July 24, 2014

Record last verified: 2014-07