NCT00976742

Brief Summary

The investigators hypothesize that the degree to which older generally healthy but sedentary men and women improve a number of cardiovascular (CV) disease risk factors with 6 months of highly-standardized endurance exercise training will be a function of common genetic variations in candidate genes.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
225

participants targeted

Target at P75+ for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 1998

Completed
6.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2004

Completed
4.8 years until next milestone

First Submitted

Initial submission to the registry

September 11, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 14, 2009

Completed
Last Updated

April 3, 2025

Status Verified

March 1, 2025

Enrollment Period

6.5 years

First QC Date

September 11, 2009

Last Update Submit

March 31, 2025

Conditions

Cardiovascular Disease Risk Factors

Keywords

plasma lipoprotein lipidsbody compositionglucose toleranceinflammation markersinsulin sensitivitycoagulation markers

Outcome Measures

Primary Outcomes (1)

  • Cardiovascular Disease Risk Factors

    ~9 months

Study Arms (1)

Endurance Exercise Training

EXPERIMENTAL
Behavioral: Endurance exercise training

Interventions

Endurance exercise trainingBEHAVIORAL
Endurance Exercise Training

Eligibility Criteria

Age50 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • generally healthy
  • free from CV disease
  • ability to undergo exercise training

You may not qualify if:

  • previous history of CV disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Maryland Dept of Kinesiology

College Park, Maryland, 20742-2611, United States

Location

Related Publications (1)

  • Halverstadt A, Phares DA, Wilund KR, Goldberg AP, Hagberg JM. Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women. Metabolism. 2007 Apr;56(4):444-50. doi: 10.1016/j.metabol.2006.10.019.

    PMID: 17378998RESULT

MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

HyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 11, 2009

First Posted

September 14, 2009

Study Start

June 1, 1998

Primary Completion

December 1, 2004

Last Updated

April 3, 2025

Record last verified: 2025-03

Locations

US(1)