Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR)

NCT00970034 | Unknown

• 1 other identifier: 108S375
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this project is to determine the morphological criteria of apoptosis in atrial tissues of patients with AF versus SR at transcriptome and genomic size.

Conditions

Mitral Regurgitation; Atrial Fibrillation; Sinus Rhythm

Keywords

Atrial fibrillation, apoptosis, oligonucleotide microarray

Outcome Measures

Primary Outcomes (1)

• Expression profiles of genes related to apoptosis

  6 months

Secondary Outcomes (1)

• Expression profiles of pro-apoptotic and anti-apoptotic proteins

  6 months

Study Arms (2)

AF

Patients with degenerative mitral valve regurgitation and permanent atrial fibrillation who require mitral valve repair or replacement.

SR

Patients with degenerative mitral valve regurgitation and maintaining sinus rhythm who require mitral valve repair or replacement.

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Degenerative mitral valve regurgitation who require cardiac valve surgery

You may qualify if:

• Patients with permanent atrial fibrillation or sinus rhythm and degenerative mitral valve regurgitation who require cardiac surgery
• Pulmonary hypertension (systolic PA \> 45 mmHg)
• Left ventricular ejection fraction \> 30%

You may not qualify if:

• Paroxysmal AF or atrial flutter
• Second or third degree heart block
• Permanent pacemaker
• Wolff-Parkinson-White syndrome
• Brugada syndrome
• Ischemic or rheumatic mitral valve disease
• Dilated cardiomyopathy
• LVEF \< 30%
• Infective endocarditis, myocarditis
• Trauma
• Active HBV, HCV, HIV infection
• Chronic renal failure
• Autoimmune diseases
• Vasculitis
• Known genetic disorders

Sponsors & Collaborators

• Ankara University: lead
• The Scientific and Technological Research Council of Turkey: collaborator

Study Sites (1)

Ankara University Medical Faculty, Department of Cardiovascular Surgery,

Ankara, 06340, Turkey (Türkiye)

RECRUITING

Related Publications (1)

• Cubukcuoglu Deniz G, Durdu S, Dogan Y, Erdemli E, Ozdag H, Akar AR. Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation. Cardiovasc Ther. 2021 Oct 15;2021:5516185. doi: 10.1155/2021/5516185. eCollection 2021.

  PMID: 34737791 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Human atrial tissue

MeSH Terms

Conditions

Mitral Valve Insufficiency; Atrial Fibrillation

Condition Hierarchy (Ancestors)

Heart Valve Diseases; Heart Diseases; Cardiovascular Diseases; Arrhythmias, Cardiac; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• RUCHAN A AKAR, Assoc. Prof.

  Ankara University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

RUCHAN AKAR, Assoc. Prof.

CONTACT

+905336460684; akarruchan@gmail.com

HILAL OZDAG, Assoc. Prof.

CONTACT

+905333717401; hilalozdag@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 1, 2009
• First Posted: September 2, 2009
• Study Start: December 1, 2008
• Study Completion: December 1, 2011
• Last Updated: September 3, 2009

Record last verified: 2009-09

Locations

TU (1)