Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation
Ultrastructure of Sarcolemma, Immunofluorescence of Calcium Handling Proteins and Mitochondrial Function in Atrial Myocytes of Patients in Sinus Rhythm and With Atrial Fibrillation
1 other identifier
observational
45
0 countries
N/A
Brief Summary
The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation. Furthermore, since current information is lacking on the key Ca2+-handling proteins RyR, NCX, and SERCA-2a from patients in Atrial Fibrillation (AF), it will be investigated whether a regulation of these proteins could be an underlying cause of the disease. Mitochondrial function will also studied.
- 1.The investigators hypothesize that both structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared with patients in sinus rhythm.
- 2.The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared with patients in sinus rhythm.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2010
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2010
CompletedFirst Submitted
Initial submission to the registry
December 13, 2011
CompletedFirst Posted
Study publicly available on registry
December 15, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2012
CompletedMarch 13, 2017
March 1, 2017
1.8 years
December 13, 2011
March 10, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
structure of sarcolemma
1 hour
Study Arms (3)
stable sinus rhythm
permanent atrial fibrillation
paroxysmal atrial fibrillation
Eligibility Criteria
selected for open heart surgery in St Olavs Hospital, Trondheim University Hospital, Norway
You may qualify if:
- sinus rhythm, permanent atrial fibrillation or paroxysmal atrial fibrillation
- selected for open heart surgery
- informed consent
You may not qualify if:
- not given informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Slagsvold KH, Johnsen AB, Rognmo O, Hoydal MA, Wisloff U, Wahba A. Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. Physiol Genomics. 2014 Jul 15;46(14):505-11. doi: 10.1152/physiolgenomics.00042.2014. Epub 2014 May 13.
PMID: 24824214RESULT
Biospecimen
Myocardial tissue from the right and left atrial appendage.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Ulrik Wisløff, PhD
Norwegian University of Science and Technology
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 13, 2011
First Posted
December 15, 2011
Study Start
April 1, 2010
Primary Completion
February 1, 2012
Study Completion
July 1, 2012
Last Updated
March 13, 2017
Record last verified: 2017-03