Role of Subsequent Atrial Tachycardia in Mechanisms of Persistent AF
The Prognostic Role of Subsequent Atrial Tachycardias Occurring After Atrial Fibrillation Termination: A Prospective Randomized Trial
1 other identifier
observational
110
1 country
1
Brief Summary
In this study, the investigators aim to examine the prognostic role of subsequent Atrial Tachycardias (ATs) in the mechanisms of atrial fibrillation (AF). Therefore, the investigators compare patients who were randomly assigned to either undergo cardioversion after AF has been terminated to AT or further ablation until the achievement of sinus rhythm.
Trial Health
Trial Health Score
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participants targeted
Target at P50-P75 for all trials
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2013
CompletedFirst Submitted
Initial submission to the registry
July 6, 2013
CompletedFirst Posted
Study publicly available on registry
July 11, 2013
CompletedJuly 11, 2013
July 1, 2013
3.8 years
July 6, 2013
July 10, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Arrhythmia-free survival
24 months after enrolment
Secondary Outcomes (1)
Type of Arrhythmia recurrence
24 months after enrolement
Other Outcomes (1)
Time to recurrence
after blanking period (3 months) until study end (at least 24 months)
Study Arms (2)
Group A: cardioversion at AT
after achievement of AT, pts were cardioverted
Group B: ablation to SR
After AT has been achieved, all subsequent AT were ablated with the endpoint of procedural SR termination
Interventions
Eligibility Criteria
Patients with persistent AF
You may qualify if:
- persistent AF for at least 1 months,
- age \> 18 years,
- refractory to drug therapy,
- no prior ablation
You may not qualify if:
- prior AF ablation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital Eppendorf, Dept. of Electrophysiology
Hamburg, D-20246, Germany
Related Publications (1)
Rostock T, Salukhe TV, Hoffmann BA, Steven D, Berner I, Mullerleile K, Theis C, Bock K, Servatius H, Sultan A, Willems S. Prognostic role of subsequent atrial tachycardias occurring during ablation of persistent atrial fibrillation: a prospective randomized trial. Circ Arrhythm Electrophysiol. 2013 Dec;6(6):1059-65. doi: 10.1161/CIRCEP.113.001019. Epub 2013 Oct 25.
PMID: 24162833DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Univ.-Prof. Dr. med.
Study Record Dates
First Submitted
July 6, 2013
First Posted
July 11, 2013
Study Start
June 1, 2009
Primary Completion
March 1, 2013
Last Updated
July 11, 2013
Record last verified: 2013-07