NCT00901979

Brief Summary

This study will assess the effect of LCQ when added to metformin.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
693

participants targeted

Target at P75+ for phase_2 type-2-diabetes-mellitus

Timeline
Completed

Started Apr 2009

Geographic Reach
5 countries

67 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2009

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

May 13, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 14, 2009

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2010

Completed
Last Updated

January 9, 2013

Status Verified

January 1, 2013

Enrollment Period

1.2 years

First QC Date

May 13, 2009

Last Update Submit

January 3, 2013

Conditions

Keywords

Type 2 Diabetes

Outcome Measures

Primary Outcomes (1)

  • Effect of LCQ on measures of glucose control

    12 weeks

Secondary Outcomes (3)

  • Changes in body weight and related measures

    12 weeks

  • Insulin sensitivity

    12 weeks

  • Safety and tolerability

    12 weeks

Study Arms (7)

LCQ908 Dose 1

EXPERIMENTAL
Drug: LCQ908ADrug: metformin

LCQ908 Dose 2

EXPERIMENTAL
Drug: LCQ908ADrug: metformin

LCQ908 Dose 3

EXPERIMENTAL
Drug: LCQ908ADrug: metformin

LCQ908 Dose 4

EXPERIMENTAL
Drug: LCQ908ADrug: metformin

LCQ908 Dose 5

EXPERIMENTAL
Drug: LCQ908ADrug: metformin

Placebo

PLACEBO COMPARATOR
Drug: PlaceboDrug: metformin

Sitagliptin

ACTIVE COMPARATOR
Drug: SitagliptinDrug: metformin

Interventions

LCQ908 Dose 1
Placebo
Sitagliptin
LCQ908 Dose 1LCQ908 Dose 2LCQ908 Dose 3LCQ908 Dose 4LCQ908 Dose 5PlaceboSitagliptin

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • HbA1c from 7.0-10.0%, Stable Metformin dose

You may not qualify if:

  • CHF Class III-IV, Liver disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (67)

Clinical Research Advantage

Mesa, Arizona, United States

Location

Mesa Family Medical Center/Clinical Research Advantage

Mesa, Arizona, United States

Location

Woodland International Reserach Group, LLC

Little Rock, Arkansas, United States

Location

Associated Pharmaceutical Research

Buena Park, California, United States

Location

John Muir Clinical Research

Concord, California, United States

Location

*Private Practice*

Pasadena, California, United States

Location

Apex Research of Riverside

Riverside, California, United States

Location

California Research Foundation

San Diego, California, United States

Location

CNRI-San Diego, LLC

San Diego, California, United States

Location

Orange County Research Center

Tustin, California, United States

Location

Diablo Clinical

Walnut Creek, California, United States

Location

Denver VA Medical Center

Denver, Colorado, United States

Location

Complete Family Care

Northglenn, Colorado, United States

Location

Research Center Phase I-IV of Florida, Corp.

Miami, Florida, United States

Location

Metabolic Research Institute, Inc.

West Palm Beach, Florida, United States

Location

Perimeter North Medical Research

Roswell, Georgia, United States

Location

MacNeal Center for Clinical Research

Berwyn, Illinois, United States

Location

Venture Resource Group

Overland Park, Kansas, United States

Location

Cotton-O'Neil Clinical Research Center Topeka KS United States

Topeka, Kansas, United States

Location

Graves Gilbert Clinic Bowling Green KY United States

Bowling Green, Kentucky, United States

Location

Commonwealth Biomedical Research, LLC

Madisonville, Kentucky, United States

Location

Centennial Medical Group

Elkridge, Maryland, United States

Location

International Research Center Towson MD United States

Towson, Maryland, United States

Location

Fallon Clinic Worcester MA United States

Worcester, Massachusetts, United States

Location

Southwestern Medical Clinic

Bridgman, Michigan, United States

Location

Clarkston Medical Group

Clarkston, Michigan, United States

Location

Michigan State University - Kalamazoo Ctr for Med Studies

Kalamazoo, Michigan, United States

Location

Mississippi Medical Research, LLC

Picayune, Mississippi, United States

Location

ClinVest Research

Springfield, Missouri, United States

Location

St. John's Clinic - Medical Research

Springfield, Missouri, United States

Location

Montana Medical Research

Missoula, Montana, United States

Location

Meera Dewan, P.C.

Omaha, Nebraska, United States

Location

Libra Clinical Research Associates

Brick, New Jersey, United States

Location

Physicians Research Center

Toms River, New Jersey, United States

Location

Endwell Family Physician

Endwell, New York, United States

Location

*Private Practice* Staten Island

Staten Island, New York, United States

Location

Medical Frontiers LLC

Carlisle, Ohio, United States

Location

Radiant Research

Greer, South Carolina, United States

Location

Southwind Medical Specialists Memphis TN United States

Memphis, Tennessee, United States

Location

Dallas Diabetic and Endocrinology Research Center

Dallas, Texas, United States

Location

Radiant Research - North Dallas

Dallas, Texas, United States

Location

Accurate Clinical Research

Houston, Texas, United States

Location

Blalock Clinical Research

Houston, Texas, United States

Location

Texas Center for Drug Development, P.A.

Houston, Texas, United States

Location

Ettrick Health Center

Ettrick, Virginia, United States

Location

McGuire Veterans Medical Center

Richmond, Virginia, United States

Location

Northwest Clinical Research

Bellevue, Washington, United States

Location

Providence Physicians Group

Monroe, Washington, United States

Location

Health Sciences Centre - Diabetes Research Group

Winnipeg, Manitoba, Canada

Location

Rivergrove Medical Clinic

Winnipeg, Manitoba, Canada

Location

Credit Valley Prof Bldg

Mississauga, Ontario, Canada

Location

Hamilton Medical Research Group

Sherbrooke, Ontario, Canada

Location

Hopital Maisonneuve-Rosemont

Montreal, Quebec, Canada

Location

Institut de Recherches Cliniques

Montreal, Quebec, Canada

Location

Clinique Médicale Millénia Santé

Québec, Quebec, Canada

Location

CHUS - Hopital Fleurimont

Sherbrooke, Quebec, Canada

Location

Azienda Ospedaliera-Ospedali Riuniti di Bergamo

Bergamo, Italy

Location

Centro Studi sull'Invecchiamento CeSI-Univers.G.D'Annunzio

Chieti, Italy

Location

A.O.Polo Universitario Luigi Sacco

Milan, Italy

Location

Istituto Scientifico San Raffaele - IRCCS

Milan, Italy

Location

Ospedale S.Giovanni di Dio

Olbia, Italy

Location

Presidio Ospedaliero di Cisanello Università degli Studi

Pisa, Italy

Location

Univ.Tor Vergata - AUSL ROMA B - Sede Territoriale

Roma, Italy

Location

Samodzielny Publiczny Zaklad Opieki Zdrowotnej

Oława, Poland

Location

Policlinica Dr. Luis Rodriguez Carrasquillo

Carolina, Puerto Rico

Location

Endocrine Lipid Diabetes Research Institute Ponce PR United States

Ponce, Puerto Rico

Location

Miguel Sosa-Padilla, M.D.

San Juan, Puerto Rico

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

Sitagliptin PhosphateMetformin

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

TriazolesAzolesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsPyrazinesBiguanidesGuanidinesAmidinesOrganic Chemicals

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 13, 2009

First Posted

May 14, 2009

Study Start

April 1, 2009

Primary Completion

June 1, 2010

Study Completion

June 1, 2010

Last Updated

January 9, 2013

Record last verified: 2013-01

Locations