NCT00891722

Brief Summary

RATIONALE: Studying samples of tumor tissue and blood in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors understand why low-grade gliomas develop in young patients and predict how they will respond to treatment. PURPOSE: This clinical trial is studying tumor tissue, blood samples, and family history in predicting tumor development and response to treatment in young patients with low-grade glioma.

Trial Health

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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
900

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2008

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

April 30, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 1, 2009

Completed
Last Updated

August 26, 2013

Status Verified

June 1, 2009

First QC Date

April 30, 2009

Last Update Submit

August 23, 2013

Conditions

Brain and Central Nervous System Tumors

Keywords

recurrent childhood brain stem gliomauntreated childhood brain stem gliomarecurrent childhood cerebellar astrocytomauntreated childhood cerebellar astrocytomachildhood low-grade cerebral astrocytomarecurrent childhood cerebral astrocytomachildhood oligodendrogliomarecurrent childhood visual pathway and hypothalamic gliomauntreated childhood visual pathway and hypothalamic gliomachildhood mixed glioma

Outcome Measures

Primary Outcomes (1)

  • Identification of factors that could determine different patterns of tumor development, natural tumor behavior, and tumor sensitivity to therapies

Interventions

biologic sample preservation procedureOTHER
laboratory biomarker analysisOTHER
questionnaire administrationOTHER

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
DISEASE CHARACTERISTICS: * Biological parents of a child or adolescent patient diagnosed with low grade glioma (LGG) * LGG patients participating in 1 of the following clinical trials: * On active follow up for study SIOP-LGG1 at a Children's Cancer and Leukemia Group center * On study SIOP-LGG-2004 * Adoptive parents or guardians allowed if they feel they have the knowledge to complete the study questionnaire, provided either or both biological parents are unable to complete the questionnaire PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Queen's Medical Centre

Nottingham, England, NG7 2UH, United Kingdom

RECRUITING

MeSH Terms

Conditions

Central Nervous System NeoplasmsAstrocytomaOligodendrogliomaOptic Nerve Glioma

Condition Hierarchy (Ancestors)

Nervous System NeoplasmsNeoplasms by SiteNeoplasmsNervous System DiseasesGliomaNeoplasms, NeuroepithelialNeuroectodermal TumorsNeoplasms, Germ Cell and EmbryonalNeoplasms by Histologic TypeNeoplasms, Glandular and EpithelialNeoplasms, Nerve TissueOptic Nerve NeoplasmsCranial Nerve NeoplasmsPeripheral Nervous System NeoplasmsCranial Nerve DiseasesOptic Nerve DiseasesEye Diseases

Study Officials

  • David A. Walker

    Queen's Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Sponsor Type
OTHER

Study Record Dates

First Submitted

April 30, 2009

First Posted

May 1, 2009

Study Start

August 1, 2008

Last Updated

August 26, 2013

Record last verified: 2009-06

Locations

GB(1)