Heart Rate Variability During Weaning From Mechanical Ventilation

NCT00851825 | Completed

• 1 other identifier: 03-435
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The discontinuation of mechanical ventilation (MV) and the recovery of spontaneous breathing can lead to important cardiovascular alterations due to changes in the intrathoracic pressure. The autonomic modulation assessed through heart rate variability (HRV) during weaning from MV and its impact on cardiorespiratory variables has not been well elucidated yet. To evaluate the effect of T-tube (TT) and pressure support ventilation (PSV) during weaning from MV on cardiorespiratory variables and heart rate variability.

Conditions

Critical Care; Weaning

Keywords

autonomic modulation; heart rate; pressure support ventilation; T-tube; Mechanical ventilation

Outcome Measures

Primary Outcomes (1)

• heart rate variability analysis

  minutes

Secondary Outcomes (1)

• Cardiorespiratory variables

  minutes

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with respiratory failure receiving MV for more than 48 hours, who had been admitted to the Intensive Care Unit (ICU) of the Hospital de Clínicas de Porto Alegre, and who met the criteria for weaning from MV according to the parameters previously defined were selected to participate in this study.

You may qualify if:

• Patients with respiratory failure receiving MV for more than 48 hours
• for weaning from MV according to the parameters previously defined were selected to participate in this study

You may not qualify if:

• arterial hypotension (systolic blood pressure \< 100mmHg), severe brain disease, barotraumas, presence of thoracic drain or tracheostomy, using vasoactive and sedative drugs

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead

Study Sites (1)

Federal University of Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, Brazil

Location

Study Officials

• Silvia R Veira, PhD

  Hospital de Clínicas de Porto Alegre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 25, 2009
• First Posted: February 26, 2009
• Study Start: March 1, 2003
• Study Completion: June 1, 2007
• Last Updated: May 8, 2009

Record last verified: 2009-05

Locations

BR (1)