NCT01155648

Brief Summary

The purpose of this study is to compare two physiotherapy techniques: chest wall compression versus chest wall compression plus increase of 10 cmH2O in inspiratory pressure.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
66

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started May 2008

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2008

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2009

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2010

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

June 23, 2010

Completed
9 days until next milestone

First Posted

Study publicly available on registry

July 2, 2010

Completed
Last Updated

July 2, 2010

Status Verified

June 1, 2010

Enrollment Period

1.1 years

First QC Date

June 23, 2010

Last Update Submit

July 1, 2010

Conditions

Keywords

Mechanical ventilationChest physiotherapyChest wall compression

Outcome Measures

Primary Outcomes (1)

  • Variation of mucus secretion aspirated.

    Two years

Secondary Outcomes (1)

  • Hemodynamic and pulmonary parameters.

    Two years

Study Arms (2)

PSV group.

EXPERIMENTAL

Chest wall compression plus increase of 10 cmH2O of PSV.

Device: Chest wall compression plus increase of 10 cmH2O in inspiratory pressure during Pressure Support Ventilation for ten minutes in chest.

chest wall compression group

ACTIVE COMPARATOR

Chest wall compression

Device: Chest wall compression for ten minutes in chest

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients on mechanical ventilation over 48 hours
  • With ventilatory drive
  • Hemodynamically stable MAP\> 60 mmHg
  • With treatment of respiratory therapy

You may not qualify if:

  • Contra indication of increased positive inspiratory pressure
  • Peak pressure in the upper airway \> 40 cmH2O
  • Osteoporosis diagnosis
  • Deny to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Location

Related Publications (2)

  • Naue Wda S, Forgiarini Junior LA, Dias AS, Vieira SR. Chest compression with a higher level of pressure support ventilation: effects on secretion removal, hemodynamics, and respiratory mechanics in patients on mechanical ventilation. J Bras Pneumol. 2014 Jan-Feb;40(1):55-60. doi: 10.1590/S1806-37132014000100008.

  • Naue Wda S, da Silva AC, Guntzel AM, Condessa RL, de Oliveira RP, Rios Vieira SR. Increasing pressure support does not enhance secretion clearance if applied during manual chest wall vibration in intubated patients: a randomised trial. J Physiother. 2011;57(1):21-6. doi: 10.1016/S1836-9553(11)70003-0.

MeSH Terms

Conditions

Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration DisordersRespiratory Tract DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Silvia R Vieira, PhD

    Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

June 23, 2010

First Posted

July 2, 2010

Study Start

May 1, 2008

Primary Completion

June 1, 2009

Study Completion

May 1, 2010

Last Updated

July 2, 2010

Record last verified: 2010-06

Locations