Attitudes About Childbearing And Fertility With Inherited Breast And Ovarian Cancer Syndromes (HBOC)

NCT00829959 | Completed

• 1 other identifier: 2008-0624
• Study Type: observational
• Target: 156
• Locations: 1 country
• Sites: 1

Brief Summary

Objectives: \- To evaluate the attitudes and opinions of women undergoing genetic counseling for hereditary breast and ovarian cancer syndrome, both before and after testing, in regards to pregnancy and fertility Hypothesis:

• Factors that will increase the percentage of women endorsing prenatal diagnostic testing will include a personal history of breast or ovarian cancer, having had a mother or sister die of breast or ovarian cancer, and testing positive for a BRCA mutation.

Conditions

Breast Cancer; Ovarian Cancer

Keywords

Ovary, Cancer; Ovarian Cancer; Breast Cancer; Hereditary Breast and Ovarian Cancer Syndrome; HBOC; Genetic testing; Pregnancy; Fertility; Prenatal diagnostic testing

Outcome Measures

Primary Outcomes (1)

• Women Endorsing Prenatal Diagnostic Testing (Questionnaire response)

  Baseline and post genetic testing (results disclosure) at 3-4 weeks

Study Arms (1)

Genetic Counseling

Women referred to the Clinical Cancer Genetics Program for discussion of Hereditary Breast And Ovarian Syndrome (HBOC).

Behavioral: Questionnaire

Interventions

Questionnaire BEHAVIORAL

1 - 2 questionnaires, lasting 10-15 minutes.

Also known as: Survey

Genetic Counseling

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Women undergoing genetic counseling within UT MDACC Clinical Cancer Genetics Program for hereditary breast and ovarian cancer syndrome (HBOC).

You may qualify if:

• Women who have been referred to the Clinical Cancer Genetics Program for discussion of Hereditary Breast And Ovarian Syndrome (HBOC).
• Participants must be seen by clinical cancer geneticist and undergo genetic counseling here at M.D. Anderson Cancer Center for HBOC.
• Participants may or may not have a personal diagnosis of cancer.
• Participants may have already seen or undergone reproductive endocrine evaluation and had any reproductive treatment.
• The participant must be a woman and have reproductive potential which would include either active menstruation, blood tests with premenopausal ranges of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) and estradiol, or was premenopausal prior to starting chemotherapy for a diagnosed breast cancer.
• Age \>/= 18 years old
• The patient must be able to speak and read fluently in either English or in Spanish in order to complete the questionnaire.

You may not qualify if:

• \) None

Sponsors & Collaborators

• M.D. Anderson Cancer Center: lead

Study Sites (1)

University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Links

• University of Texas MD Anderson Cancer Center Website

MeSH Terms

Conditions

Breast Neoplasms; Ovarian Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Endocrine Gland Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders; Neoplastic Syndromes, Hereditary; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Jennifer Litton, MD

  M.D. Anderson Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 26, 2009
• First Posted: January 27, 2009
• Study Start: February 1, 2009
• Primary Completion: August 1, 2016
• Study Completion: August 1, 2016
• Last Updated: August 4, 2016

Record last verified: 2016-08

Locations

US (1)