Content, Bioavailability and Health Effects of Trace Elements and Bioactive Components in Organic Agricultural Systems

NCT00738166 | Completed

• 2 other identifiers: H-C-2007-0078M194
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Trace elements, bioactive secondary metabolites and vitamins are among the most important quality parameters in plants. Yet, very little information is available on their content, bioavailability and health effects of organically grown plant food products. The main objective of the project is to study the impact of different agricultural management practises relevant for organic farming on the ability of cereal and vegetable crops to absorb trace elements from the soil and to synthesise bioactive compounds (secondary metabolites, antioxidant vitamins and phytates) with health promoting effects. Field experiments with a rigidly controlled design will be implemented together with state-of-the-art analytical techniques allowing solid conclusions to be drawn on the variability and optimum levels of bioactive compounds. The multitude of analytical data from plant and soil samples will be analysed by multivariate statistical methods in order to reveal differences between the cultivation systems used. Finally, the relationship between bioavailability of the nutrients studied and the elemental fingerprint of plants will be extracted by the statistical methods.

Conditions

Healthy

Keywords

diet, organic, health; healthy people

Outcome Measures

Primary Outcomes (1)

• Bioavailability of trace elements and secondary metabolites

  3 x 12 days

Secondary Outcomes (1)

• Health factors

  3 x 12 days

Other Outcomes (1)

• miRNA

  1 year

Study Arms (3)

II

EXPERIMENTAL

organic animal manure

Other: Organic or conventional diet; Other: Diet (organic or conventional)

III

ACTIVE COMPARATOR

conventional

Other: Organic or conventional diet; Other: Diet (organic or conventional)

I

EXPERIMENTAL

organic green manure

Other: Organic or conventional diet; Other: Diet (organic or conventional)

Interventions

Organic or conventional diet OTHER

12 days on fully controlled organic 1 diet, organic 2 diet and conventional diet

I; II; III

Diet (organic or conventional) OTHER

organic or conventional diet

I; II; III

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults aged 18-45 years
• BMI 20-30 kg/m2
• Non-vegetarian

You may not qualify if:

• Physical activity \> 10 h/week
• Intake of dietary supplements
• Regular use of drugs
• Chronic diseases
• Smoking
• Excessive intake of alcohol

Sponsors & Collaborators

• University of Copenhagen: lead

Study Sites (1)

IHE-LIFE

Frederiksberg, 1984, Denmark

Location

MeSH Terms

Interventions

Diet; Congresses as Topic

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Organizations; Health Care Economics and Organizations

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 19, 2008
• First Posted: August 20, 2008
• Study Start: October 1, 2007
• Primary Completion: January 1, 2010
• Study Completion: December 1, 2010
• Last Updated: July 29, 2016

Record last verified: 2011-02

Locations

DK (1)