The Effect of Aging and Immobilisation on Muscle

NCT00559806 | Completed

• 1 other identifier: KF01-322606
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

Conditions

Healthy

Keywords

immobilisation; aging; resistance training; atrophy; The effect of immobilisation in elderly compared to young individuals

Outcome Measures

Primary Outcomes (1)

• muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation

  2 weeks of immobilisation and 4 weeks of resistance training

Secondary Outcomes (1)

• single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number

  2 weeks of imm and 4 weeks of resistance training

Study Arms (2)

1

EXPERIMENTAL

9 healthy elderly males

Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training

2

EXPERIMENTAL

11 healthy young males

Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training

Interventions

2 weeks of unilateral immobilisation and 4 weeks of resistance training OTHER

2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

1

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)

You may not qualify if:

• Musculoskeletal disorder
• Diabetes
• Cardiovascular disease
• Neurological diseases; or
• Cognitive disorders

Sponsors & Collaborators

• Bispebjerg Hospital: lead

Study Sites (1)

Institute of Sports Medicine, Bispebjerg Hospital

Copenhagen, 2400-NV, Denmark

Location

MeSH Terms

Conditions

Atrophy

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Charlotte Suetta, MD, PhD

  Institute of Sports Medicine Copenhagen, Bispebjerg Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 15, 2007
• First Posted: November 16, 2007
• Study Start: January 1, 2007
• Study Completion: May 1, 2007
• Last Updated: November 16, 2007

Record last verified: 2007-11

Locations

DK (1)