NCT00611156

Brief Summary

The objective of this study is to examine whether four different spices (ginger, black pepper, horseradish and mustard) are able to increase energy metabolism. Since chili and other spices have been shown to increase energy expenditure compared to placebo, we expect that some or all of the four spices may actually increase energy expenditure - although not to a large degree.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
22

participants targeted

Target at P25-P50 for not_applicable healthy

Timeline
Completed

Started Oct 2006

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2006

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2007

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

January 28, 2008

Completed
11 days until next milestone

First Posted

Study publicly available on registry

February 8, 2008

Completed
Last Updated

February 8, 2008

Status Verified

August 1, 2007

First QC Date

January 28, 2008

Last Update Submit

February 7, 2008

Conditions

Healthy

Keywords

ThermogenesisMeal-induced thermogenesisenergy expenditurefat oxidationbioactive ingredientsspicesgingerhorseradishblack peppermustard

Outcome Measures

Primary Outcomes (1)

  • energy expenditure

    November 2007

Secondary Outcomes (6)

  • blood pressure

    December 2007

  • heart rate

    December 2007

  • VAS-scores for appetite, hunger, fullness, etc. - and palatability

    November 2007

  • tolerance

    November 2007

  • Fat and carbohydrate oxidation

    November 2007

  • +1 more secondary outcomes

Study Arms (5)

A

EXPERIMENTAL

Spice

Dietary Supplement: ginger

B

EXPERIMENTAL

Spice

Dietary Supplement: black pepper

C

EXPERIMENTAL

Spice

Dietary Supplement: horseradish

D

EXPERIMENTAL

Spice

Dietary Supplement: mustard

E

PLACEBO COMPARATOR

Placebo

Dietary Supplement: placebo

Interventions

gingerDIETARY_SUPPLEMENT

added to a brunch meal

A
black pepperDIETARY_SUPPLEMENT

Added to a brunch meal

B
horseradishDIETARY_SUPPLEMENT

Added to a brunch meal

C
mustardDIETARY_SUPPLEMENT

Added to a brunch meal

D
placeboDIETARY_SUPPLEMENT

Added to a bruch meal

E

Eligibility Criteria

Age18 Years - 50 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • male
  • healthy and not use medication (regularly)
  • normal weight
  • non smoker
  • tolerate and like spicy food
  • stable body weight last two months

You may not qualify if:

  • increased blood pressure
  • abnormal EKG
  • mental, metabolic and chronic diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Human Nutrition, The Royal Veterinary and Agricultural University

Frederiksberg, DK-1958, Denmark

Location

Related Publications (1)

  • Gregersen NT, Belza A, Jensen MG, Ritz C, Bitz C, Hels O, Frandsen E, Mela DJ, Astrup A. Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite, ad libitum energy intake and energy balance in human subjects. Br J Nutr. 2013 Feb 14;109(3):556-63. doi: 10.1017/S0007114512001201. Epub 2012 Jul 5.

    PMID: 23021155DERIVED

MeSH Terms

Interventions

ginger extractblack pepper oilAmines

Intervention Hierarchy (Ancestors)

Organic Chemicals

Study Officials

  • Arne Astrup, Professor MD

    Department of Human Nutrition, RVAU

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 28, 2008

First Posted

February 8, 2008

Study Start

October 1, 2006

Study Completion

June 1, 2007

Last Updated

February 8, 2008

Record last verified: 2007-08

Locations

DK(1)