NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock

NCT00736723 | Completed Results

• 1 other identifier: Anae_ICU_Ulm_NT-proBNP
• Study Type: observational
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine the course of NT-proBNP plasma concentrations in the context of confounding parameters in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.

Conditions

SIRS; Sepsis; Shock; Critically Ill; Multiple Organ Dysfunction Syndrome

Keywords

NT-proBNP; myocardial dysfunction; humans; patients; polytrauma; complement; inflammation; inflammatory response; biomarkers; cytokines; cell surface markers; functional polymorphisms; infections; systemic inflammatory response syndrome; SIRS; sepsis; severe sepsis; shock; organ dysfunctions; SOFA; severity of disease; APACHEII; SAPSII; SPAPS3; length of stay; outcome; mortality

Outcome Measures

Primary Outcomes (1)

• Pattern of NT-proBNP, Biomarkers and Surface Markers on Leukocytes

  maximal NT-proBNP concentrations in critically ill surgical patients admitted from 01 July 2008 to 31 Dec 2008 in the ICU revealingnonseptic and septic shock

  01 July 2008 to 31 Dec 2008

Study Arms (2)

Patients non-septic shock

Postoperative/posttraumatic critically ill patients with non-septic shock

Patients septic shock

Postoperative/posttraumatic critically ill patients with septic shock

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Postoperative/posttraumatic critically ill patients admitted to the intensive care unit

You may qualify if:

• Critically ill, postoperative/posttraumatic patients with severe systemic inflammatory response syndrome (SIRS) or severe sepsis

You may not qualify if:

• Life expectancy \< 24 hours
• Participation in other trials
• Known or suspected pregnancy
• Contraindications for transesophageal echocardiography (TEE): severe disease of the esophagus (hernia, strictures, esophageal resection, severe bleeding disorders)

Sponsors & Collaborators

• University of Ulm: lead

Study Sites (1)

Clinic of Anesthesiology

Ulm, 89070, Germany

Location

Related Publications (2)

• Weiss M, Huber M, Nass M, Huber-Lang M, Koenig W, Schneider M. NT-proBNP and HMGB1 in surgical critically ill patients with hypovolemic or septic shock.Infection Suppl. II September 2011; 39: S116-117 5th International Congress of the German Sepsis Society, Weimar Sepsis Update Bridging The Gap, Weimar, 07. - 10.09.2011.

  RESULT

• Weiss M, Huber M, Nass M, Huber-Lang M, Koenig W, Schneider M. NT-proBNP serum concentrations in surgical critically ill patients with non-septic and septic shock. INNOVATIVE JOURNAL OF MEDICAL AND HEALTH SCIENCE 3 (4): 177-184, 2013.

  RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, serum, white blood cells

MeSH Terms

Conditions

Sepsis; Shock; Critical Illness; Multiple Organ Failure; Multiple Trauma; Inflammation; Infections; Systemic Inflammatory Response Syndrome

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Disease Attributes; Wounds and Injuries

Limitations and Caveats

Myocardial depression has not been verified in our patients by a low cardiac index or by echocardiography

Results Point of Contact

• Title: Prof. Dr. Manfred Weiss
• Organization: University

manfred.weiss@uni-ulm.de

#49 731 500 60226

Study Officials

• Manfred Weiss, MD, MBA

  Clinic of Anesthesiology, University Hospital Medical School, Steinhoevelstrasse 9, 89070 Ulm, Germany

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, MD, MBA

Study Record Dates

• First Submitted: August 14, 2008
• First Posted: August 18, 2008
• Study Start: August 1, 2008
• Primary Completion: August 1, 2012
• Study Completion: December 1, 2012
• Last Updated: January 1, 2025
• Results First Posted: January 20, 2017

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)