NCT00745888

Brief Summary

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients. The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

Trial Health

55
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2007

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

September 2, 2008

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 3, 2008

Completed
Last Updated

September 9, 2009

Status Verified

August 1, 2009

First QC Date

September 2, 2008

Last Update Submit

September 4, 2009

Conditions

SepsisShock

Keywords

oxidative stressintensive carePostoperative intensive care

Outcome Measures

Primary Outcomes (1)

  • 28-day Survival

    28 days

Secondary Outcomes (1)

  • Days stay in ICU Days on ventilator SOFA score Complications

    28 days

Study Arms (1)

1

age \> 18 y/o Patients admitted to surgical ICU

Other: Chemiluminescence Analyzer

Interventions

Chemiluminescence AnalyzerOTHER

measure reactive oxygen species

1

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients admitted to surgical ICU

You may qualify if:

  • Age \> 18 y/o
  • Admitted to surgical ICU

You may not qualify if:

  • Patients with brain death

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood sample

MeSH Terms

Conditions

SepsisShock

Condition Hierarchy (Ancestors)

InfectionsSystemic Inflammatory Response SyndromeInflammationPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Yu-Chang Yeh

    National Taiwan University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yu-Chang Yeh, MD

CONTACT

886-9-68661829tonyyeh@ntuh.gov.tw

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 2, 2008

First Posted

September 3, 2008

Study Start

May 1, 2007

Last Updated

September 9, 2009

Record last verified: 2009-08

Locations

TW(1)