Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure
Serve-HF
Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure
2 other identifiers
interventional
1,325
11 countries
267
Brief Summary
The purpose of this trial is to evaluate the long-term effects and cost-effectiveness of adaptive servo-ventilation (ASV) on the mortality and morbidity of patients with stable heart failure due to left ventricular systolic dysfunction, already receiving optimal medical therapy, who have sleep disordered breathing (SDB) that is predominantly central sleep apnea. Assumptions: the intervention reduces the hazard rate by 20%. The event rate in the control group is 35% in the first year. It is assumed that the hazard rate is constant over time.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable heart-failure
Started Feb 2008
Longer than P75 for not_applicable heart-failure
267 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2008
CompletedFirst Submitted
Initial submission to the registry
February 14, 2008
CompletedFirst Posted
Study publicly available on registry
August 13, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2015
CompletedResults Posted
Study results publicly available
May 12, 2020
CompletedMay 12, 2020
April 1, 2020
7.2 years
February 14, 2008
April 28, 2017
April 29, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
All Cause Mortality or Unplanned Hospitalisation/Prolongation of Hospitalisation for Worsening Heart Failure
time to first event, assessed for up to 70 weeks
Cardiovascular Mortality or Unplanned Hospitalisation/Prolongation of Hospitalisation for Worsening Heart Failure
time to first event, assessed for up to 70 weeks
All Cause Mortality or All Cause Unplanned Hospitalisation/Prolongation of Hospitalisation
time to first event, assessed for up to 70 weeks
Secondary Outcomes (39)
Death From Any Cause
the last follow up or at the last available observation within Follow Up (FU), assessed for up to 70 weeks
Non-cardiovascular Death
the last follow up or at the last available observation within FU, assessed for up to 70 weeks
Cardiovascular Death
the last follow up or at the last available observation within FU, assessed for up to 70 weeks
Unplanned Hospitalisation/Prolongation of Hospitalisation Due to Worsening of Heart Failure
the last follow up or at the last available observation within FU, assessed for up to 70 weeks
Unplanned Hospitalisation/Prolongation of Hospitalisation for Other Reasons or Death
the last follow up or at the last available observation within FU, assessed for up to 70 weeks
- +34 more secondary outcomes
Study Arms (2)
Treatment Group
ACTIVE COMPARATORtreatment with Adaptive Servoventilation (Europe: AutoSet CS (USA: VPAP (Variable Positive Airway Pressure) Adapt SV)) + standard medical therapy according to applicable guidelines (ESC, ACC/AHA)
Control Group
NO INTERVENTIONstandard medical therapy according to applicable guidelines (ESC, ACC/AHA)
Interventions
At least 3 hours average daily usage time
Eligibility Criteria
You may qualify if:
- Patients must be at least 22 years old
- Chronic heart failure (at least 12 weeks since diagnosis) according to the current applicable guidelines (ESC, ACC/AHA)
- Left ventricular systolic dysfunction (LVEF ≤45% by imaging method such as echocardiography, radionuclide angiography, left ventriculography, or cardiac magnetic resonance imaging) documented less than 12 weeks before randomisation
- Optimised medical treatment according to applicable guidelines with no new class of disease modifying drug for more than 4 weeks prior to randomisation. In case of no beta blockers or ACE (angiotensin converting Enzyme) inhibitors/ ARB (angiotensin receptor blocker) antagonists the reasons must be documented
- SDB (AHI \> 15/h with ≥ 50% central events and a central AHI ≥ 10/h, derived from polygraphy or polysomnography (based on total recording time (TRT)), documented less than 4 weeks before randomisation. Flow measurement has to be performed with nasal cannula
- Patients for whom the use of AutoSet CS2 (TM)/VPAP Adapt may be contra-indicated because of symptomatic hypotension or significant intravascular volume depletion or pneumothorax or pneumomediastinum
- Patient is able to fully understand study information and signed informed consent
You may not qualify if:
- Significant COPD (chronic obstructive pulmonary disease) with Forced Expiratory Volume within one second (FEV1) \<50% (European Respiratory Society criteria) in the last four weeks before randomisation
- Current use of Positive Airway Pressure (PAP) - therapy
- Life expectancy \< 1 year for diseases unrelated to chronic HF
- Cardiac surgery, Percutaneous coronary intervention (PCI), Myocardial Infarction (MI) or unstable angina within 6 months prior to randomisation
- CRT (cardiac resynchronisation therapy)-implantation or ICD-implantation scheduled or within 6 months prior to randomisation
- Transient ischemic attack (TIA) or Stroke within 3 months prior to randomisation
- Primary hemodynamically significant uncorrected valvular heart disease, obstructive or regurgitant, or any valvular disease expected to lead to surgery during the trial
- Acute myocarditis/pericarditis within 6 months prior to randomisation
- Untreated or therapy refractory Restless legs-Syndrome (RLS) according to criteria listed in Appendix IX at the time of study entry
- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- ResMedlead
- CRI-The Clinical Research Institute GmbHcollaborator
Study Sites (267)
Westmead Hospital
Westmead, New South Wales, 2145, Australia
Rivercity Private Hospital
Auchenflower, Queensland, 4066, Australia
Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
St Vincents and Mercy Private Hospital
Melbourne, Victoria, 3065, Australia
Melbourne Sleep Disorders Centre
East Melbourne, Victoria 3002, 3002, Australia
Hollywood Private Hospital (CVS)
Nedlands, Western Australia, 6009, Australia
St. Anne's University Hospital BRNO
Brno, 65691, Czechia
Århus Universitets Hospital
Århus C, 8000, Denmark
Århus Universitets Hospital Skejby
Århus N, 8200, Denmark
Rigshospitalet
Copenhagen, 2100, Denmark
Bispebjerg Hospital
Copenhagen, 2400, Denmark
Dansk Center For Søvnmedicin
Glostrup Municipality, 2600, Denmark
Glostrup Hospital
Glostrup Municipality, 2600, Denmark
Helsinki University Hospital
Helsinki, 00290, Finland
Unesta Research Centre
Tampere, 33520, Finland
Tampere University Hospital, Pirkanmaa sairaanhoitopiiri
Tampere, 33521, Finland
Cardiologist Dr. Papola
Amnéville, 57360, France
CHU Angers
Angers, 49933, France
Centre Hospitalier d'Antibes Juan-les-Pins
Antibes, 06606, France
Hopital Prive d'Antony
Antony, 92166, France
CH Belfort
Belfort, 90000, France
CH de Besancon
Besançon, 25000, France
Centre Hospitalier de Béziers
Béziers, 34525, France
Clinique du Tondu
Bordeaux, 33000, France
Hôpital St. André
Bordeaux, 33000, France
Praxis Cardiologique Dr. Puel
Bordeaux, 33000, France
Praxis Cardiologique Dr. Wickers
Bordeaux, 33000, France
CHU Bordeaux, Hopital Pellegrin
Bordeaux, 33076, France
CHU de Caen
Caen, 14033, France
Centre Hospitalier de Cannes
Cannes, 06401, France
Hopital Henri Mondor
Créteil, 94010, France
Hôpital Sud
Échirolles, 38434, France
CH de Forbach, Hospitalor, Hopital Marie Madeleine-Pneumology
Forbach, 57604, France
CH de Forbach-Cardiology
Forbach, 57604, France
Clinique Mutualiste des Eaux Claires
Grenoble, 38000, France
CHU Grenoble, Hopital Michallon
Grenoble, 38043, France
CH Haguenau
Haguenau, 67504, France
Clinique de L'Union
L'Union, 31240, France
CHU Lille- Hopital Cardiologique
Lille, 59037, France
CHU Lille-Sleep medicine
Lille, 59037, France
Polyclinique La Louviere
Lille, 59042, France
Hospices Civils de Lyon, Hopital de la Croix-Rousse
Lyon, 69317, France
CHR Metz, Hôpital de Bon-Secours
Metz, 57000, France
CH Montbeliard
Montbéliard, 25209, France
CHU de Montpellier
Montpellier, 34295, France
CH Intercommunal André Grégoire
Montreuil, 93105, France
CH de Mulhouse, Hopital Emile Muller
Mulhouse, 68070, France
Clinique les Fleurs
Ollioules, 83190, France
Hôpital Bichat
Paris, 75018, France
CHU Tenon
Paris, 75790, France
CHU de Bordeaux, Hopital Haut Leveque
Pessac, 33600, France
CHU de Poitiers
Poitiers, 86000, France
Cabinet de cardiologie
Pont-à-Mousson, 54700, France
CH Rene Dubos
Pontoise, 95303, France
Polyclinique Saint-Laurent
Rennes, 35706, France
CHU de Rouen, Hopital de Bois Guillaume
Rouen, 76031, France
CH Lemire - St Avold
Saint-Avold, BP 30011, France
CH de St Dié des Vosges
Saint-Dié, 88187, France
CHU de Saint-Etienne, Hopital Nord
Saint-Etienne, 42055, France
Clinique des Trois Frontières
Saint-Louis, 68300, France
CHU Toulouse, Hopital de Rangueil
Toulouse, 31059, France
CHU Toulouse, Hopital Larrey
Toulouse, 31059, France
CH Trouville
Trouville, 14360, France
CHU de Nancy, Hopital Brabois
Vandœuvre-lès-Nancy, 54511, France
Ch St. Nicolas
Verdun, 55100, France
Cardiopraxis Ingelheim
Ingelheim, Rhineland-Palatinate, 55218, Germany
Praxis Dr. Frieske
Aachen, 52062, Germany
Universitätsklinikum Aachen
Aachen, 52074, Germany
DRK Krankenhaus
Alzey, 55232, Germany
Gemeinschaftspraxis Weiß / Dr. Heesing
Arnsberg, 59821, Germany
Zentralklinikum Bad Berka
Bad Berka, 99437, Germany
Herzzentrum Bad Krozingen
Bad Krozingen, 79189, Germany
Klinik Lazariterhof
Bad Krozingen, 79189, Germany
Schlaflabor Breisgau
Bad Krozingen, 79189, Germany
Praxis Dr. Bauer
Bad Mergentheim, 97980, Germany
Herz- und Diabeteszentrum NRW
Bad Oeynhausen, 32545, Germany
Oberlausitz-Kliniken gGmbH
Bautzen, 02625, Germany
Kardiologie Brühl
Bergheim, 50126, Germany
Kardiopraxis Rheinberg
Bergisch Gladbach, 51465, Germany
Charité Campus Mitte - Kardiologie
Berlin, 10117, Germany
Charité Campus Mitte CCM- Schlafmedizinisches Zentrum
Berlin, 10117, Germany
POLIKUM Friedenau
Berlin, 12157, Germany
Gemeinschaftspraxis Groß-Ziethener Chaussee
Berlin, 12355, Germany
Unfallkrankenhaus Berlin
Berlin, 12683, Germany
Evangelische Lungenfachklinik Buch
Berlin, 13125, Germany
Jüdisches Krankenhaus Berlin
Berlin, 13347, Germany
Charité Campus Virchow Klinikum
Berlin, 13353, Germany
Praxis Westend
Berlin, 14050, Germany
Herzzentrum Brandenburg
Bernau, 16321, Germany
Praxis für Lunge, Herz und Schlaf
Bielefeld, 33617, Germany
Kardiologie Gemeinschaftspraxis Dres Tenholt&Metzger&Dexling
Bochum, 44787, Germany
Universitätsklinikum Bergmannsheil
Bochum, 44789, Germany
Augusta Krankenanstalten Bochum
Bochum, 44791, Germany
St.-Josephs-Hospital
Bochum, 44791, Germany
Kardiologie Kemnade
Bochum, 44797, Germany
Kardiologische Praxis Dr. Staubach
Bochum, 44866, Germany
Universitätsklinikum Bonn
Bonn, 53127, Germany
Kardiologische Praxis Marschner
Bonn, 53225, Germany
Helios Klinikum Borna
Borna, 04552, Germany
Gemeinschaftspraxis Kardiologie
Bottrop, 46236, Germany
Klinikum Bremen Ost
Bremen, 28325, Germany
Kardiologie Brühl
Brühl, 50321, Germany
Mediclin Rehazentrum Spreewald
Burg, 03096, Germany
Gemeinschaftspraxis Kardiologie Dr. Becker
Castrop-Rauxel, 44575, Germany
Kardiologische Praxis Dr. Isbruch
Castrop-Rauxel, 44577, Germany
MVZ am Küchwald
Chemnitz, 09113, Germany
Klinikum Coburg GmbH
Coburg, 96450, Germany
St.-Vinzenz Hospital
Cologne, 50733, Germany
Kardiologische Praxis Dr. Fritsch
Cologne, 50737, Germany
Malteser Krankenhaus St.Hildegardis
Cologne, 50931, Germany
Prof. Franzen Institut
Cologne, 50937, Germany
Praxis Dr. Anselm Bäumer
Cologne, 51065, Germany
Gemeinschaftspraxis Dres. Gysan/Heinzler/May
Cologne, 51105, Germany
Fachkrankenhaus Coswig
Coswig, 01640, Germany
Carl-Thiem-Klinikum gGmbH
Cottbus, 03042, Germany
Ambulantes Zentrum für Lungenkrankheiten&Schlafmedizin
Cottbus, 03050, Germany
MECS Cottbus GmbH
Cottbus, 03050, Germany
Praxis Dr. Hecker
Dortmund, 44135, Germany
Kardiologische Praxis Dr. Golling
Dortmund, 44137, Germany
Clinical Trial Site Services
Dortmund, 44141, Germany
Kardiologische Praxis Dr. Wetzel
Dortmund, 44141, Germany
Kardiologische Praxis Dr. Lodde
Dortmund, 44147, Germany
Kardiologische Praxis Dr. Dröse
Dortmund, 44263, Germany
Facharztzentrum Dresden-Neustadt GbR
Dresden, 01099, Germany
Gemeinschaftspraxis Dres. Schmidt/Gronke
Dresden, 01219, Germany
Praxis Dr. Hohensee
Dresden, 01277, Germany
Herzzentrum Universität Dresden
Dresden, 01307, Germany
goMedus Gesundheitszentrum
Düsseldorf, 40212, Germany
Kardiologische Praxis Dr. Horowitz
Düsseldorf, 40215, Germany
Evangelisches Krankenhaus
Düsseldorf, 40217, Germany
Kardiologische Praxis Dr. Raff
Düsseldorf, 40237, Germany
Florence-Nightingale Krankenhaus
Düsseldorf, 40489, Germany
Kardiologie Oberkassel
Düsseldorf, 40545, Germany
Gemeinschaftspraxis PD. Dr. Lankisch
Düsseldorf, 40597, Germany
Fachärzte für Innere Medizin Dres Ritter, Richter, Mehrer, Kahl
Emmendingen, 79312, Germany
Helios Klinikum Erfurt-Kardiologie
Erfurt, 99089, Germany
Helios Klinikum Erfurt-Schlafmedizin
Erfurt, 99089, Germany
Universitätsklinikum Erlangen
Erlangen, 91054, Germany
Westdeutsches Herzzentrum, Universitätsklinikum Essen
Essen, 45122, Germany
Kardiologische Praxis Dr. Cord Müller
Essen, 45131, Germany
Schwerpunktpraxis Kardiologie Drs. Ophoff/Fritzsch
Essen, 45131, Germany
Kardiologische Praxis Prof. Winter
Essen, 45134, Germany
Kardiologie Praxis Dr. Bonnekamp
Essen, 45136, Germany
Praxis Dr. Tekiyeh
Essen, 45136, Germany
Elisabeth-Krankenhaus Essen
Essen, 45138, Germany
Ruhrlandklinik Essen
Essen, 45239, Germany
Praxis Dr. Rau
Essen, 45276, Germany
Kath. Kliniken Essen / Philippusstift
Essen, 45359, Germany
Gemeinschaftspraxis Dres. Guckenbiehl
Flonheim, 55237, Germany
Kardiologische Praxis Dr. Kruse
Forst, 03149, Germany
CardioVasculäres Centrum Frankfurt
Frankfurt, 60389, Germany
Praxis Dr. Diedrichs
Frechen, 50226, Germany
Universitaetsklinikum Freiburg
Freiburg im Breisgau, 79106, Germany
Gemeinschaftspraxis Dres. Böhmeke/Schmidt
Gladbeck, 45964, Germany
Kardiologische Praxis Dr. Hug
Günzburg, 89312, Germany
Kardiologische Praxis Gütersloh
Gütersloh, 33334, Germany
Gemeinschaftspraxis Dres Leischik/Littwitz
Hagen, 58095, Germany
Kardiologische Praxis Dr. Arens
Hagen, 58095, Germany
Gemeinschaftspraxis Dres. Subin/Lutter
Hamburg, 20095, Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
Asklepios Klinik Barmbek
Hamburg, 22291, Germany
Internistenpraxis Alstertal Hamburg
Hamburg, 22399, Germany
Kardiologische Praxis Dr. Cierpka
Hanover, 30159, Germany
Praxis Dr. Hötte
Hanover, 30449, Germany
Siloah Krankenhaus
Hanover, 30449, Germany
Kardiologische Praxis Dr. Hartung
Hanover, 30559, Germany
MH Hannover
Hanover, 30625, Germany
Klinikum Hannover Oststadt-Heidehaus
Hanover, 30659, Germany
Praxis Dr. Durak
Heidelberg, 69115, Germany
Universitätsklinikum Heidelberg
Heidelberg, 69120, Germany
Thoraxklinik Heidelberg gGmbH
Heidelberg, 69126, Germany
Lungenklinik Hemer
Hemer, 58675, Germany
Kardiologische Praxis Dr. Furche
Herne, 44623, Germany
Gemeinschaftspraxis Dr. Bruch
Herne, 44629, Germany
Kardiologische Praxis Dr. Schlichting
Herne, 44649, Germany
Augusta-Kranken-Anstalt gGmbH Thoraxzentrum Ruhrgebiet
Herne, 44651, Germany
St. Elisabeth-Hospital Herten gGmbH
Herten, 45699, Germany
Lungenfachklinik Immenhausen
Immenhausen, 34376, Germany
Gemeinschaftspraxis Dres. Dobler/Turin
Karlstadt am Main, 97753, Germany
Ambulantes Herzzentrum Kassel
Kassel, 34121, Germany
Kardiologische Praxis Dr. Siegfried Frickel
Kempen, 47906, Germany
Klinikum Dahme-Spreewald GmbH
Königs Wusterhausen, 15711, Germany
Praxis Dr. Krater
Krefeld, 47799, Germany
Helios Klinikum Krefeld
Krefeld, 47805, Germany
Universitätsklinikum Leipzig-Herzzentrum
Leipzig, 04289, Germany
Helios Krankenhaus Leisnig
Leisnig, 04703, Germany
Gemeinschaftspraxis Dr. Hilgedieck/Sava
Lengerich, 49525, Germany
Kardiologische Praxis Dr. Faber
Lindlar, 51784, Germany
Ärztezentrum Holthausen-Biene
Lingen, 49808, Germany
Universitätsklinikum Schleswig-Holstein Campus Lübeck-Kardiologie
Lübeck, 23538, Germany
Universitätsklinikum Schleswig-Holstein Campus Lübeck-Schlaflabor
Lübeck, 23538, Germany
Klinikum der Johannes Gutenberg-Universität Mainz
Mainz, 55101, Germany
Cardiopraxis Ingelheim
Mainz, 55116, Germany
Universitätsklinikum Mannheim-Schlafmedizin
Mannheim, 68135, Germany
Gemeinschaftspraxis Dres. Heifer/Loster/Schernus
Mannheim, 68161, Germany
Gemeinschaftspraxis für Herz & Gefäße
Mannheim, 68161, Germany
Universitätsklinik Mannheim-Kardiologie
Mannheim, 68167, Germany
Gemeinschaftspraxis Dres. Brandt / Jakobs
Mannheim, 68305, Germany
Universitätsklinikum Gießen / Marburg, Standort Marburg-Schlafmedizin
Marburg, 35033, Germany
Universitätsklinikum Gießen/Marburg Standort Marburg-Kardiologie
Marburg, 35043, Germany
Praxis Dr. Schnabel
Meissen, 01662, Germany
Gemeinschaftspraxis Dr. Jocham
Memmingen, 87700, Germany
Praxis Für Kardiologie Dr. med. Menz
Menden, 58706, Germany
Krankenhaus Bethanien
Moers, 47441, Germany
Kardiologische Praxis Dr. Schön
Mühldorf, 84453, Germany
Evangelisches Krankenhaus Mülheim
Mülheim, 45468, Germany
Kardiologie am Rotkreuzplatz
München, 80634, Germany
Lungenärzte am Rotkreuzplatz
München, 80634, Germany
Gemeinschaftspraxis Dres. Wauer / Windstetter
München, 80799, Germany
Kardiologische Praxis Dr. Herholz
München, 80809, Germany
Klinik Augustinum München
München, 81375, Germany
Praxis Dres. Böhme/Linke
München, 81667, Germany
Kardiologische Praxis Dr. Muradi
Münster, 29633, Germany
Universitätsklinikum Münster
Münster, 48149, Germany
Praxis für Kardiologie Dr. med. Hewing
Münster, 48151, Germany
Lukaskrankenhaus GmbH
Neuss, 41464, Germany
Kardiologische Praxis Nienburg
Nienburg, 31582, Germany
Klinikum Nürnberg Nord
Nuremberg, 90419, Germany
Klinikum Nürnberg Süd
Nuremberg, 90471, Germany
Kardiologische Praxis Dr. Gumbrecht
Ochtrup, 48607, Germany
Kardiologische Praxis Dr. Wiethölter
Radebeul, 01445, Germany
Praxis für Kardiologie Ratingen
Ratingen, 40878, Germany
Praxis Dr. Fröhlich
Ratingen, 40885, Germany
DRK Krankenhaus Mölln-Ratzeburg
Ratzeburg, 23909, Germany
Ambulantes Cardiovaskuläres Centrum
Ravensburg, 88212, Germany
Gemeinschaftspraxis Dr. Weber/Dr. Feja
Recklinghausen, 45657, Germany
Knappschafts-Krankenhaus Recklinghausen
Recklinghausen, 45657, Germany
Universitätsklinikum Regensburg
Regensburg, 93053, Germany
Krankenhaus Reinbek St. Adolf-Stift
Reinbek, 21465, Germany
Praxis Dr. Hein
Reinbek, 21465, Germany
Praxis Dr. Nebel
Rheine, 48429, Germany
Praxis Dr. Kestermann
Rheine, 48431, Germany
Praxis Dr. Ebeling
Schönefeld, 12529, Germany
Kardiologische Praxis Dr. Heinze
Schwerte, 58239, Germany
Praxisgemeinschaft Cardio-Soest
Soest, 59494, Germany
Facharztzentrum Sonneberg
Sonneberg, 96515, Germany
Kreiskrankenhaus Stollberg GmbH
Stollberg, 09366, Germany
Klinikum Uelzen GmbH
Uelzen, 29525, Germany
Herzklinik Ulm Dr. Haerer und Partner
Ulm, 89077, Germany
Zentrum für Innere Medizin Uni Ulm
Ulm, 89081, Germany
Katharinen Hospital Unna
Unna, 59423, Germany
Kardiologische Praxis Dr. Burkhard-Meier
Viersen, 41747, Germany
Praxis Dr. Gerritsen
Waldkraiburg, 84478, Germany
Fachkliniken Wangen
Wangen, 88239, Germany
Stiftungsklinik Weißenhorn
Weißenhorn, 89264, Germany
Kardiologische Praxis Dr. Vrettos
Witten, 58452, Germany
Kardiologische Praxis Dr. Rudolf/ Dr. Bernhardt
Worms, 67547, Germany
Missionsärztliche Klinik Würzburg
Würzburg, 97074, Germany
Universitätsklinikum Würzburg
Würzburg, 97080, Germany
Evangel. Khs Zweibrücken
Zweibrücken, 66482, Germany
University Medical Center Groningen
Groningen, 9700, Netherlands
Ullevål University Hospital
Oslo, 0407, Norway
Oslo University Hospital, Rikshospitalet
Oslo, 0424, Norway
Stavanger AS
Stavanger, 4011, Norway
Sahlgrenska University Hospital / Östra
Gothenburg, 41345, Sweden
Sahlgrenska University Hospital / Östra
Gothenburg, U/6 85, Sweden
Specialistläkarmottagning Residenset AB
Jönköping, 55316, Sweden
Skaraborgs Hospital
Lidköping, 53185, Sweden
Linköping University Hospital
Linköping, 58185, Sweden
Cardiocentro Ticino
Lugano, 6900, Switzerland
Ospedale Regionale di Lugano
Lugano, 6903, Switzerland
Castle Hill Hospital
Cottingham, East Yorkshire, HU165JQ, United Kingdom
Chesterfield Royal Hospital
Chesterfield, Calow S44 5DX, United Kingdom
Brompton Hospital
London, SW36NP, United Kingdom
Freeman Hospital
Newcastle, NE7 7DN, United Kingdom
Musgrove Park Hospital
Taunton, TA1 5DA, United Kingdom
Royal Wolverhampton Hospitals NHS Trust
Wolverhampton, WV10 0QP, United Kingdom
Related Publications (6)
Cowie MR, Wegscheider K, Teschler H. Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. N Engl J Med. 2016 Feb 18;374(7):690-1. doi: 10.1056/NEJMc1515007. No abstract available.
PMID: 26886528RESULTEulenburg C, Wegscheider K, Woehrle H, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H, Cowie MR. Mechanisms underlying increased mortality risk in patients with heart failure and reduced ejection fraction randomly assigned to adaptive servoventilation in the SERVE-HF study: results of a secondary multistate modelling analysis. Lancet Respir Med. 2016 Nov;4(11):873-881. doi: 10.1016/S2213-2600(16)30244-2. Epub 2016 Aug 31.
PMID: 27592224RESULTWoehrle H, Cowie MR, Eulenburg C, Suling A, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H, Wegscheider K. Adaptive servo ventilation for central sleep apnoea in heart failure: SERVE-HF on-treatment analysis. Eur Respir J. 2017 Aug 31;50(2):1601692. doi: 10.1183/13993003.01692-2016. Print 2017 Aug.
PMID: 28860264RESULTTamisier R, Pepin JL, Woehrle H, Salvat M, Barone-Rochette G, Rocca C, Vettorazzi E, Teschler H, Cowie M, Levy P. Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study. Eur Respir J. 2023 Feb 9;61(2):2200384. doi: 10.1183/13993003.00384-2022. Print 2023 Feb.
PMID: 36229051DERIVEDShafazand S, Badr MS. Adaptive Servo-Ventilation and Central Apnea Associated with Systolic Heart Failure. J Clin Sleep Med. 2016 Jan;12(1):147-50. doi: 10.5664/jcsm.5420. No abstract available.
PMID: 26888594DERIVEDCowie MR, Woehrle H, Wegscheider K, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H. Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med. 2015 Sep 17;373(12):1095-105. doi: 10.1056/NEJMoa1506459. Epub 2015 Sep 1.
PMID: 26323938DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Martin R. Cowie, MD
- Organization
- Department of Cardiology, Imperial College London, Dovehouse St., London SW3 6LY, United Kingdom
Study Officials
- PRINCIPAL INVESTIGATOR
Helmut Teschler, Prof.
Universitätsklinikum Essen
- PRINCIPAL INVESTIGATOR
Martin Cowie, Prof.
National Heart and Lung Institute (NHLI) Brompton Hospital, London
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 14, 2008
First Posted
August 13, 2008
Study Start
February 1, 2008
Primary Completion
April 1, 2015
Study Completion
June 1, 2015
Last Updated
May 12, 2020
Results First Posted
May 12, 2020
Record last verified: 2020-04