Establishment of a Brain and Spinal Tumor Tissue Bank

NCT00686387 | Unknown

• 1 other identifier: 2008WFCRC-01
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to establish a Brain and Spinal Tumor Tissue/Specimen repository to serve as a resource for current and future scientific studies.

Conditions

Glioblastoma Multiforme; Glioma; Neuroectodermal Tumors

Keywords

Tissue Bank; Glioblastoma Multiforme; NAT2; EGFR; MGMT; Brain and Spinal TumorGliomas

Outcome Measures

Primary Outcomes (1)

• Collect, annotate, and store fresh frozen specimens of normal tissue, tumors, and pre-malignant lesions for biological investigation.

  5 years

Secondary Outcomes (7)

• Collect, process, and store serum, plasma and isolate lymphocytes from blood drawn from patients with Brain and Spinal Tumor

  5 years

• Establish a database to link materials acquisition, pathologic, and clinical information on patients who participate in the protocol

  5 years

• To utilize the clinical database to perform clinical and pathological correlation with the results of current and future scientific studies

  5 years

• To evaluate various NAT2, EGFR and MGMT for evidence of genomic and biochemical activation

  5 years

• To test the effect of small molecule inhibitors on the activation of wild-type and mutant NAT2, EGFR, MGMT and/or other potential molecular targets

  5 years

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Neurosurgery clinic or oncology clinic in Wan Fang Hospital

You may qualify if:

• Patients must have a suspected or confirmed diagnosis of Brain and Spinal Tumor
• Age greater than 20
• Signed consent

You may not qualify if:

• Known HIV infection
• Any other clinical condition which, in the opinion of the principal investigator, would not allow completion of this study

Sponsors & Collaborators

• Taipei Medical University WanFang Hospital: lead

Study Sites (1)

Taipei Medical University-Wan Fang Hospital

Taipei, 116, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, Fresh tissue

MeSH Terms

Conditions

Glioblastoma; Glioma; Neuroectodermal Tumors

Condition Hierarchy (Ancestors)

Astrocytoma; Neoplasms, Neuroepithelial; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Study Officials

• Kuo-Sheng Hung, MD, PhD

  Taipei Medical University-Wan Fang Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kuo-Sheng Hung, M.D., Ph. D.

CONTACT

886-2-2930-7930; kshung25@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 26, 2008
• First Posted: May 29, 2008
• Study Start: May 1, 2008
• Primary Completion: May 1, 2013
• Study Completion: May 1, 2013
• Last Updated: April 12, 2011

Record last verified: 2011-04

Locations

TW (1)