Key Insights

Highlights

Success Rate

75% trial completion

Published Results

85 trials with published results (20%)

Research Maturity

189 completed trials (44% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

14.8%

63 terminated out of 426 trials

Success Rate

75.0%

-11.6% vs benchmark

Late-Stage Pipeline

4%

17 trials in Phase 3/4

Results Transparency

45%

85 of 189 completed with results

Key Signals

85 with results75% success63 terminated

Data Visualizations

Phase Distribution

373Total
Not Applicable (38)
Early P 1 (19)
P 1 (171)
P 2 (128)
P 3 (17)

Trial Status

Completed189
Terminated63
Recruiting57
Unknown53
Active Not Recruiting31
Withdrawn20

Trial Success Rate

75.0%

Benchmark: 86.6%

Based on 189 completed trials

Clinical Trials (426)

Showing 20 of 20 trials
NCT01837862Phase 1Active Not Recruiting

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

NCT03862430Phase 2Active Not RecruitingPrimary

A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM

NCT05708352Phase 2RecruitingPrimary

A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment

NCT00083512RecruitingPrimary

Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme

NCT05303467Phase 1RecruitingPrimary

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

NCT06991101Phase 2Recruiting

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

NCT07416188Phase 1Recruiting

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

NCT03911388Phase 1Recruiting

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

NCT05023551Early Phase 1Active Not Recruiting

Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

NCT02974738Phase 1Active Not Recruiting

A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001)

NCT04900792Phase 1Active Not Recruiting

A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma

NCT06814496Phase 1Recruiting

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

NCT02704858Phase 1Active Not RecruitingPrimary

Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma

NCT05864976RecruitingPrimary

Neurosurgical Neuronavigation Using Resting State MRI and Machine Learning

NCT02177578Phase 2Active Not RecruitingPrimary

Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

NCT06333899Early Phase 1Recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

NCT00209989Phase 2CompletedPrimary

Phase II Trial to Assess the Radiosensitizing Effect of ZARNESTRA in Patients With Glioblastoma Multiforme

NCT06157541Phase 1Active Not RecruitingPrimary

T Cells and Pembrolizumab for Recurrent and Newly Diagnosed Glioblastoma

NCT05120284Phase 2Active Not RecruitingPrimary

Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)

NCT03389802Phase 1Active Not RecruitingPrimary

Phase I Study of APX005M in Pediatric Central Nervous System Tumors

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