Aging, Lifestyle and Inflammation in Veterans Exercising

NCT00667030 | Completed DMC

• 1 other identifier: HP-00041199
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Over half of adults in this country are overweight. This increases risk for heart and blood pressure problems, cancer, stroke and arthritis. While it is difficult to lose large amounts of weight and keep it off, even small amounts of weight loss can improve health. Furthermore, fat is increasingly recognized as a source of substances that increase inflammation. It may be that some of the adverse consequences of being overweight are due to increased inflammation. We are asking you to volunteer for a research study in which you may lose a moderate amount of weight and increase your activity. It is important that you read and understand the information on this form. The purposes of these studies are to determine the influence(s) of age and body composition on the production of inflammatory chemicals by fat (adipose tissue), the mechanisms controlling this, and if a weight loss and aerobic exercise intervention results in a decrease in inflammation.

Conditions

Exercise; Inflammation; Aging; Metabolism

Keywords

Inflammation; Aging; Metabolism; Exercise

Outcome Measures

Primary Outcomes (1)

• Regional Adipokine Release

  6 month

Secondary Outcomes (1)

• Cardiovascular Fitness Body Composition Glucose Tolerance/Insulin Sensitivity

  6 month

Study Arms (1)

Lifestyle Modification

EXPERIMENTAL

Combined hypocaloric diet and aerobic exercise training

Behavioral: Weight loss and aerobic exercise training

Interventions

Weight loss and aerobic exercise training BEHAVIORAL

Weight loss and aerobic exercise training

Lifestyle Modification

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI 20-40 kg/m2
• Waist 80-120cm (men), 70-110cm (women)
• Stable Medical Regimen \> or = 30 days
• All women over the age of 50 must be postmenopausal for at least 1 year, have serum FSH \>30 mIU/ml, and agree to remain off hormone replacement therapy for the duration of the study

You may not qualify if:

• Pregnancy or Nursing Mothers
• Cigarette Smoking
• Diabetes on Medication or Fasting Glucose \>126 mg/dl
• Poorly controlled hypertension requiring \>3 drugs or beta blockers
• Hyperlipidemia with TG\>400mg/dl, LDL\>190mg/dl or on Lipitor or Crestor
• Other medications affecting glucose, lipid or cytokine levels
• Thyroid Disease
• Weight gain/loss \>5kg in preceding 3 months
• Alcohol \>3oz/day
• Caffeine \>120 oz/day
• Chronic liver, renal or hematological disease
• Lung disease requiring oxygen
• Active cancer on radiation or chemotherapy treatment
• HIV (+) or other disease prone to malnutrition
• Sickle cell anemia

Sponsors & Collaborators

• University of Maryland, Baltimore: lead
• US Department of Veterans Affairs: collaborator

Study Sites (1)

University of Maryland; Baltimore VA Medical Center

Baltimore, Maryland, 21044, United States

Location

MeSH Terms

Conditions

Inflammation; Motor Activity

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Jacob B Blumenthal, MD

  Baltimore VA Medical Center, University of Maryland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: GRECC Investigator

Study Record Dates

• First Submitted: April 23, 2008
• First Posted: April 25, 2008
• Study Start: July 1, 2005
• Primary Completion: September 13, 2018
• Study Completion: September 13, 2018
• Last Updated: February 20, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)