NCT00663546|Completed
Malaria Studies in Cambodia
Studies of P. Vivax and P. Falciparum Malaria in Cambodia
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Studies of P. Vivax and P. Falciparum Malaria in Cambodia
Sponsor study identifier
Secondary identifiers
observational
1,978
1 country
3
Study Start
March 24, 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
December 5, 2013
Date type not reportedThis date has not been verified as actual or estimated.
This study, conducted by the National Center for Parasitology, Entomology and Malaria Control of Cambodia s Ministry of Health and the National Institute of Allergy and Infectious Diseases, will explore whether the following factors confer protection against malaria and associated anemia: certain blood groups, the hemoglobin E variant, G6PD-deficiency and alpha-thalassemia. Malaria is caused by parasites (P. falciparum and P. vivax) that are transmitted to humans through mosquito bites. This protocol includes two studies, a cohort study and a P. vivax collection study. Individuals are eligible for enrollment in the studies as follows: Cohort study: Residents of all ages of Kandal, Ekapheap and Sangkumthmey villages (Thmar Da commune) who plan to remain in Thmar Da commune for the next 5 years. P. vivax collection study: 2 years of age and older Participating in NIAID protocol 05-I- N210 ( Severe Malaria and Anti-malarial Drug Resistance in Cambodia ) and diagnosed with P. vivax malaria Participants undergo the following procedures: Cohort study: Baseline evaluation, including the following:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 5, 2013
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 24, 2008
Date type not reportedThis date has not been verified as actual or estimated.
April 19, 2008
Actual (reported)April 22, 2008
Actual (reported)December 5, 2013
Date type not reportedThis date has not been verified as actual or estimated.
National Center for Parasitology, Entomology, and Malaria Controk, Ministry of H
Phnom Penh, Cambodia
Preah Vihear Referral Hospital
Preah Vihear Province, Cambodia
Ratanakiri Referral Hospital
Ratanakiri Province, Cambodia
Frischer H, Bowman J. Hemoglobin E, an oxidatively unstable mutation. J Lab Clin Med. 1975 Apr;85(4):531-9.
Lachant NA, Tanaka KR. Impaired antioxidant defense in hemoglobin E-containing erythrocytes: a mechanism protective against malaria? Am J Hematol. 1987 Nov;26(3):211-9. doi: 10.1002/ajh.2830260302.
Hill AV. Molecular epidemiology of the thalassaemias (including haemoglobin E). Baillieres Clin Haematol. 1992 Jan;5(1):209-38. doi: 10.1016/s0950-3536(11)80042-9.
Rick M Fairhurst, M.D.
National Institute of Allergy and Infectious Diseases (NIAID)
1,978 participants (actual enrollment reported by the registry).
First Submitted
April 19, 2008
First Posted
April 22, 2008
Study Start
March 24, 2008
Date type not reportedThis date has not been verified as actual or estimated.
Congenital and Neonatal Malaria in Mali
Contact the study team to confirm eligibility.
Fantin RF, Coelho CH, Berhe AD, Magalhaes LMD, Pereira DB, Salinas ND, Tolia NH, Amaratunga C, Suon S, Sagara I, Narum DL, Fujiwara RT, Abejon C, Campos-Neto A, Duffy PE, Bueno LL. Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America. PLoS Negl Trop Dis. 2023 Apr 7;17(4):e0011229. doi: 10.1371/journal.pntd.0011229. eCollection 2023 Apr.
Hostetler JB, Sharma S, Bartholdson SJ, Wright GJ, Fairhurst RM, Rayner JC. A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions. PLoS Negl Trop Dis. 2015 Dec 23;9(12):e0004264. doi: 10.1371/journal.pntd.0004264. eCollection 2015 Dec.
Amaratunga C, Sreng S, Mao S, Tullo GS, Anderson JM, Chuor CM, Suon S, Fairhurst RM. Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat province, Western Cambodia. Antimicrob Agents Chemother. 2014 Oct;58(10):6270-2. doi: 10.1128/AAC.03026-14. Epub 2014 Jul 21.
Study Completion
December 5, 2013
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
August 20, 2018
Record last verified: 2013-12-05
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