Correlates of Protection in Ghana

NCT00138307 | Completed

• 1 other identifier: 04-027
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 2

Brief Summary

Malaria is a sickness passed from one person to the other by the bite of a mosquito. In areas of frequent malaria infection, children may develop natural protection against malaria and they are less likely to become sick or die from it as they age. The purpose of this study is to investigate the body's natural protection against malaria in children by testing their blood. This information may help investigators develop a malaria vaccine. The Navrongo Health Research Centre is conducting this study in Ghana. Three hundred healthy children between the ages of 1 and 5 years will participate in the study for 12 months. Study procedures will include 7 field worker visits to check on the child's health and obtain a blood sample. Every two months, a blood sample will be taken from each child to test it for strength against malaria. Whenever a child is sick, the child will be tested for malaria.

Conditions

Malaria

Keywords

malaria, children, naturally acquired immunity, Ghana

Eligibility Criteria

• Age: 1 Year - 5 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Male and female children aged between 1-5 years.
• Willingness of parent or guardian to give and sign a consent form and have the child participate in this study.
• The expectation of continuous residency in the Kassena-Nankana District for the entire study period

You may not qualify if:

• Pre-existing chronic disease at the time of enrollment.
• Acute illness at the time of enrollment.
• Hemoglobin less than 6.0g/dL at the time of enrollment.
• Inability of the child's parent or guardian to give informed consent.
• Expectation of possible unavailability to continue participation in the study.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (2)

Noguchi Memorial Institute of Medical Research

Legon, Ghana

Location

Navrongo Health Research Centre

Navrongo, Ghana

Location

MeSH Terms

Conditions

Malaria

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: August 26, 2005
• First Posted: August 30, 2005
• Study Completion: March 1, 2006
• Last Updated: August 27, 2010

Record last verified: 2007-03

Locations

GH (2)