NCT00661128

Brief Summary

Sudden cardiac arrest (SCA) is a sudden, unexpected loss of heart function. It is a leading cause of death, and more than 400,000 people in the United States die each year as a result of SCA. This study will analyze genetic samples of people who have experienced SCA and people who have not experienced SCA to determine if there is a genetic basis for SCA.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
14,862

participants targeted

Target at P75+ for all trials

Timeline
52mo left

Started Sep 2007

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress81%
Sep 2007Aug 2030

Study Start

First participant enrolled

September 1, 2007

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

April 16, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

April 18, 2008

Completed
22.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2030

Last Updated

June 5, 2023

Status Verified

June 1, 2023

Enrollment Period

22.9 years

First QC Date

April 16, 2008

Last Update Submit

June 1, 2023

Conditions

Death, Sudden, Cardiac

Keywords

Sudden Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

  • Genetic factors that may predispose people to develop SCA

    Measured throughout the study

Study Arms (4)

1

European American people who have experienced SCA.

2

European American people who have not experienced SCA.

3

African American people who have experienced SCA.

4

African American people who have not experienced SCA.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The group of people who have experienced SCA will be selected from participants in the Cardiac Arrest Blood Study (CABS), participants in the Cardiovascular Health Study (CHS), and residents of Seattle and King County, WA who experience SCA. The control group of people who have not experienced SCA will be selected from participants in CABS, participants in the Heart and Vascular Health Study, participants in CHS, and residents of Seattle and King County, WA who have not experienced SCA.

You may qualify if:

  • Experienced incident SCA
  • Matched to people with SCA on age, gender, and ethnicity

You may not qualify if:

  • Members of a vulnerable population

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cardiovascular Health Research Unit, University of Washington

Seattle, Washington, 98101, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

De-identified white blood cells, red blood cells, plasma, and DNA

MeSH Terms

Conditions

Death, Sudden, Cardiac

Condition Hierarchy (Ancestors)

Heart ArrestHeart DiseasesCardiovascular DiseasesDeath, SuddenDeathPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Nona Sotoodehnia, MD, MPH

    University of Washington

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Medicine, Medicine/Cardiology

Study Record Dates

First Submitted

April 16, 2008

First Posted

April 18, 2008

Study Start

September 1, 2007

Primary Completion (Estimated)

August 1, 2030

Study Completion (Estimated)

August 1, 2030

Last Updated

June 5, 2023

Record last verified: 2023-06

Locations

US(1)