Huntsman Biopsy Study

NCT00615329 | Terminated

• 2 other identifiers: Huntsman Cancer InstituteIRB 4795
• Study Type: observational
• Target: 142
• Locations: 1 country
• Sites: 1

Brief Summary

Bone and soft tissue sarcomas are currently classified based upon light microscopy supplemented by immunohistochemistry, but within many if not all of these tumor histologic types, considerable heterogeneity exists not only in microscopic appearance but also in biologic behavior and prognosis. Progress in the directed treatment of these tumors, particularly the sarcomas, awaits characterization of the gene profiles for these tumors. Orthopedic oncology researchers at Huntsman Cancer Institute at the University of Utah are establishing a tumor bank for this purpose. The long term objectives of this work include:

1. 1.creating tumor specific gene profiles to improve diagnostic accuracy
2. 2.performing gene set validation for diagnostic predictive power
3. 3.defining a discriminate gene list implicated in pathogenesis

Conditions

Soft Tissue Sarcoma; Osteosarcoma

Keywords

Create tumor specific gene profiles to improve diagnostic accuracy; Perform gene set validation for diagnostic predictive power; Define deviant gene list implicated in pathogenesis

Outcome Measures

Primary Outcomes (1)

• Classification of sarcomas

  sarcomas will be classified by researchers at Huntsman Institute

  Upon collection/analysis of sarcoma

Study Arms (1)

Soft tissue tumor

Any patient with soft tissue tumor will be asked to give a sample for this study

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who present to Doctor Damron for care relating to a bone or soft tissue tumor that has been established to be or is suspected to possibly be a sarcoma AND who will require a diagnostic or therapeutic surgical procedure which will result in procurement of tissue for histologic review will be approached in the consent process.

You may qualify if:

• Bone or soft tissue tumor that has been established to be or is suspected to possibly be a sarcoma AND who will require a diagnostic or therapeutic surgical procedure which will result in procurement of tissue for histologic review

You may not qualify if:

• Non cancer patients

Sponsors & Collaborators

• State University of New York - Upstate Medical University: lead
• Huntsman Cancer Institute: collaborator

Study Sites (1)

SUNY Upstate Medical University

Syracuse, New York, 13202, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

cDNA microarrays facilitate the systematic and comprehensive analysis of transcriptional alterations occurring in diseased tissues.

MeSH Terms

Conditions

Sarcoma; Osteosarcoma

Condition Hierarchy (Ancestors)

Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Bone Tissue; Neoplasms, Connective Tissue

Study Officials

• Timothy A Damron, MD

  State University of New York - Upstate Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 1, 2008
• First Posted: February 14, 2008
• Study Start: April 1, 2003
• Primary Completion: February 1, 2014
• Study Completion: February 1, 2014
• Last Updated: November 25, 2014

Record last verified: 2014-11

Locations

US (1)