Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:

NCT00615628 | Terminated

• 2 other identifiers: Osteosarcoma & Paget's DiseaseIRB #4168
• Study Type: observational
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.

Conditions

Osteosarcoma; Paget's Disease

Keywords

Inheritance of Osteosarcoma & Paget's Disease through Chromosome 18

Outcome Measures

Primary Outcomes (1)

• Loss of heterozygosity

  A loss of heterozygosity of a proposed tumor suppressor gene on chromosome 18

  January, 2000 through February 2009

Study Arms (1)

family members

family members of the proband and father identified

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18. The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.

You may not qualify if:

• The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.
• Not part of the family

Sponsors & Collaborators

• State University of New York - Upstate Medical University: lead

Study Sites (1)

SUNY Upstate Medical University

Syracuse, New York, 13202, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Once a specimen is obtained DNA will be isolated for paraffin-embedded tissue and peripheral blood. Osteosarcoma samples from paraffin embedded, formalin-fixed post-surgical tissue samples will be obtained for the proband and father. Matched normal spamples will be obtained from these individuals as adjacent normal tissue from the post-surgical specimens

MeSH Terms

Conditions

Osteosarcoma; Osteitis Deformans

Condition Hierarchy (Ancestors)

Neoplasms, Bone Tissue; Neoplasms, Connective Tissue; Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms; Sarcoma; Bone Diseases; Musculoskeletal Diseases

Study Officials

• Timothy A Damron, MD

  State University of New York - Upstate Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 1, 2008
• First Posted: February 14, 2008
• Study Start: April 1, 2002
• Primary Completion: December 1, 2009
• Study Completion: December 1, 2009
• Last Updated: May 30, 2013

Record last verified: 2013-05

Locations

US (1)