Functional and Neurochemical Brain Changes in First-episode Bipolar Mania

NCT00609193 | Completed

• 1 other identifier: BITREC - Project I
• Study Type: observational
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to use magnetic resonance imaging (MRI) to examine brain structure, function and chemistry in people with bipolar disorder who are being treated with either quetiapine or lithium. Both of these medicines are FDA-approved to treat mania in adults and lithium is also FDA approved in children; quetiapine is commonly used in children with mania, but is not FDA approved for this indication in this age group.

Conditions

Bipolar Disorder

Outcome Measures

Primary Outcomes (1)

• The purpose of this study is to use magnetic resonance imaging (MRI) to examine brain structure, function and chemistry in people with bipolar disorder who are being treated with either quetiapine or lithium.

  8 weeks

Study Arms (2)

1

Study subjects receiving lithium

Drug: lithium

2

Study subjects receiving quetiapine

Drug: quetiapine

Interventions

lithium DRUG

standard clinical care

1

quetiapine DRUG

standard clinical care

2

Eligibility Criteria

• Age: 12 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

You are being asked to take part in this research study because you have been diagnosed with bipolar disorder and are currently experiencing mania. Mania is identified by periods of extreme elation or irritability, excessive energy, racing thoughts, difficulty sleeping, poor judgment and/or reckless behavior. Bipolar disorder is an illness in which people experience mania as well as mood swings into depression. To participate in this study you must be at least 12 years old and no older than 35.

You may qualify if:

• Patients meet DSM-IV criteria for type I bipolar disorder, manic or mixed.
• Patients have an index Young Mania Rating Scale (YMRS)70 total score \>20.
• Patients have \<3 months of lifetime anti-manic or anti-depressant medication exposure, including no active psychotropic medication in the one weeks prior to the index admission. Importantly, patients will NOT be taken off medications for this study; this criterion is to exclude subjects receiving active treatment at the time of admission to support the 'first-episode' criterion.
• Patients have no more than two prior episodes of major depression.
• Patients are between 12 and 35 years old; subjects \< 18 yrs old have a Tanner greater than or equal to 4

You may not qualify if:

• Any chemical use disorder within 3 months.
• Any medical or neurological disorder that could influence fMRI and MRS results.
• A history of mental retardation or an estimated IQ total score \<85.
• An MRI scan is contraindicated in the subject.
• The patient cannot attend follow-up visits.
• A positive urine pregnancy test (in women).

Sponsors & Collaborators

• University of Cincinnati: lead
• National Institutes of Health (NIH): collaborator

Study Sites (1)

University of Cincinnati

Cincinnati, Ohio, 45267-0559, United States

Location

Related Publications (3)

• Lei D, Li W, Tallman MJ, Strakowski SM, DelBello MP, Rodrigo Patino L, Fleck DE, Lui S, Gong Q, Sweeney JA, Strawn JR, Nery FG, Welge JA, Rummelhoff E, Adler CM. Changes in the structural brain connectome over the course of a nonrandomized clinical trial for acute mania. Neuropsychopharmacology. 2022 Oct;47(11):1961-1968. doi: 10.1038/s41386-022-01328-y. Epub 2022 May 18.

  PMID: 35585125 DERIVED

• Lippard ETC, Weber W, Welge J, Adler CM, Fleck DE, Almeida J, DelBello MP, Strakowski SM. Variation in rostral anterior cingulate functional connectivity with amygdala and caudate during first manic episode distinguish bipolar young adults who do not remit following treatment. Bipolar Disord. 2021 Aug;23(5):500-508. doi: 10.1111/bdi.13025. Epub 2020 Nov 18.

  PMID: 33089593 DERIVED

• Strakowski SM, Fleck DE, Welge J, Eliassen JC, Norris M, Durling M, Komoroski RA, Chu WJ, Weber W, Dudley JA, Blom TJ, Stover A, Klein C, Strawn JR, DelBello MP, Lee JH, Adler CM. fMRI brain activation changes following treatment of a first bipolar manic episode. Bipolar Disord. 2016 Sep;18(6):490-501. doi: 10.1111/bdi.12426. Epub 2016 Sep 19.

  PMID: 27647671 DERIVED

MeSH Terms

Conditions

Bipolar Disorder

Interventions

Lithium; Quetiapine Fumarate

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Metals, Alkali; Elements; Inorganic Chemicals; Metals, Light; Metals; Dibenzothiazepines; Thiazepines; Thiepins; Sulfur Compounds; Organic Chemicals; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds

Study Officials

• Stephen M Strakowski, MD

  University of Cincinnati

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Academic Director of Medicine

Study Record Dates

• First Submitted: January 23, 2008
• First Posted: February 6, 2008
• Study Start: January 1, 2008
• Primary Completion: June 1, 2015
• Study Completion: July 1, 2015
• Last Updated: December 7, 2015

Record last verified: 2015-12

Locations

US (1)