Success Metrics

Clinical Success Rate
85.5%

Based on 59 completed trials

Completion Rate
86%(59/69)
Active Trials
8(9%)
Results Posted
44%(26 trials)
Terminated
10(11%)

Phase Distribution

Ph phase_4
31
34%
Ph phase_1
10
11%
Ph phase_3
19
21%
Ph not_applicable
14
16%
Ph phase_2
10
11%
Ph early_phase_1
1
1%

Phase Distribution

11

Early Stage

10

Mid Stage

50

Late Stage

Phase Distribution85 total trials
Early Phase 1First-in-human
1(1.2%)
Phase 1Safety & dosage
10(11.8%)
Phase 2Efficacy & side effects
10(11.8%)
Phase 3Large-scale testing
19(22.4%)
Phase 4Post-market surveillance
31(36.5%)
N/ANon-phased studies
14(16.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

79.7%

59 of 74 finished

Non-Completion Rate

20.3%

15 ended early

Currently Active

8

trials recruiting

Total Trials

90

all time

Status Distribution
Active(8)
Completed(59)
Terminated(15)
Other(8)

Detailed Status

Completed59
Terminated10
unknown8
Recruiting6
Withdrawn5
Active, not recruiting2

Development Timeline

Analytics

Development Status

Total Trials
90
Active
8
Success Rate
85.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.2%)
Phase 110 (11.8%)
Phase 210 (11.8%)
Phase 319 (22.4%)
Phase 431 (36.5%)
N/A14 (16.5%)

Trials by Status

active_not_recruiting22%
completed5966%
recruiting67%
withdrawn56%
unknown89%
terminated1011%

Recent Activity

Clinical Trials (90)

Showing 20 of 90 trialsScroll for more
NCT06751875Not Applicable

Preventing Relapse After Successful Electroconvulsive Therapy for Depression

Completed
NCT00025935

Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

Recruiting
NCT06929273Phase 3

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

Recruiting
NCT03336918

Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Active Not Recruiting
NCT06729970Phase 1

A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants

Completed
NCT05603104Phase 3

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure

Recruiting
NCT05913947Phase 4

Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9)

Recruiting
NCT05973786Phase 3

The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Recruiting
NCT06339034Phase 1

Repurposing Lithium for Parkinson's Disease: a RCT

Active Not Recruiting
NCT03153280Phase 1

Dose Escalation Study of Lithium With Oxaliplatin and Capecitabine in Advanced Oesophago-Gastric or Colorectal Cancer

Terminated
NCT05618587Phase 2

Effect of Lithium Therapy on Long COVID Symptoms

Completed
NCT06108297Phase 1

Lithium Long COVID Dose-finding Study

Completed
NCT01416220Phase 4

Lithium Versus Paroxetine in Major Depression

Withdrawn
NCT00703677Phase 1

A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration

Completed
NCT02129348Phase 2

Treatment of Psychosis and Agitation in Alzheimer's Disease

Completed
NCT01928446Phase 2

Lithium for Suicidal Behavior in Mood Disorders

Terminated
NCT06051240Phase 2

Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy

Recruiting
NCT00221429Phase 3

Lithium Versus Divalproex for Treating Pediatric Bipolar Disorder

Completed
NCT06005155

Lithium Versus Anticonvulsants and the Risk of Physical Disorders

Completed
NCT04273932Phase 1

Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease.

Completed

Drug Details

Intervention Type
DRUG
Total Trials
90