NCT00595595

Brief Summary

Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue in order to revitalize teeth.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,080

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2007

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2007

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

January 7, 2008

Completed
9 days until next milestone

First Posted

Study publicly available on registry

January 16, 2008

Completed
4.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2012

Completed
Last Updated

September 17, 2012

Status Verified

September 1, 2012

Enrollment Period

5.6 years

First QC Date

January 7, 2008

Last Update Submit

September 14, 2012

Conditions

Dental Pulp RegenerationDental Pulp Diseases

Keywords

Dental PulpRegenerative MedicineOdontoblastsStem CellsGrowth factor differentiation of stem/progenitor cellsOdontoblast-specific cell phenotypes

Eligibility Criteria

Age16 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients presenting for surgical removal of impacted teeth

You may qualify if:

  • Pre-existing indication for surgical extraction of impacted teeth
  • Age 16-65

You may not qualify if:

  • Ages less than 16 or over 65
  • No pre-existing indication for surgical extraction of impacted teeth

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

extracted teeth 10ml of blood for DNA banking

MeSH Terms

Conditions

Dental Pulp Diseases

Condition Hierarchy (Ancestors)

Tooth DiseasesStomatognathic Diseases

Study Officials

  • Kenneth M Hargreaves, DDS, PhD

    The University of Texas Health Science Center at San Antonio

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Chair, Dept. of Endodontics

Study Record Dates

First Submitted

January 7, 2008

First Posted

January 16, 2008

Study Start

February 1, 2007

Primary Completion

September 1, 2012

Study Completion

September 1, 2012

Last Updated

September 17, 2012

Record last verified: 2012-09

Locations

US(1)