NCT05310500

Brief Summary

The goal of the endodontic treatment is to make the root canal system free of the bacteria and its products to maximum extent, to allow healing of the inflamed apical periodontium. Nickel titanium files have super elasticity, better cutting efficiency, and shapes canal anatomy more efficiently as compared to stainless steel manual files. Regardless of these properties, main shortcoming of Ni-Ti based files is their tendency to fracture unexpectedly inside the root canals. This abrupt file separation could be due to mechanical friction or chemical stimuli leading to the damage of surface contents (wear) and formation of micro cracks, waviness, scratches or roughness. Sodium Hypochlorite is considered a gold standard irrigant in endodontics that renders bacteria free root canal system, but it has been postulated to have many shortcomings and certain concentrations of Sodium Hypochlorite affects the properties of Ni-Ti rotary instruments. This clinical trial aimed to compare the physical properties (dimensional stability, deformation, surface roughness and metal slivering) and impact of 5.25% sodium hypochlorite on these physical properties of Protaper Gold finishing F2 Files and Dia-X ProTaper finishing D4 files when subjected to root canal preparation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
24

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2018

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2018

Completed
3.9 years until next milestone

First Submitted

Initial submission to the registry

December 8, 2021

Completed
12 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 20, 2021

Completed
26 days until next milestone

Study Completion

Last participant's last visit for all outcomes

January 15, 2022

Completed
3 months until next milestone

First Posted

Study publicly available on registry

April 5, 2022

Completed
Last Updated

April 5, 2022

Status Verified

April 1, 2022

Enrollment Period

4 years

First QC Date

December 8, 2021

Last Update Submit

April 2, 2022

Conditions

Keywords

root canalpro taper golddia x pro tapersodium hypochlorite

Outcome Measures

Primary Outcomes (4)

  • Stereomicroscope and Optical microscope used to evaluate the changes of finishing files of ProTaper Gold (F2) and Dia-X ProTaper (D4).

    The change in dimensional stability of two file systems before and after clinical application and after exposure to Sodium Hypochlorite in root canal system.

    9 Months

  • Stereomicroscope and Optical microscope used to evaluate the changes of finishing files of ProTaper Gold (F2) and Dia-X ProTaper (D4).

    The change in surface roughness of two file systems before and after clinical application and after exposure to Sodium Hypochlorite in root canal system.

    9 months.

  • Stereomicroscope and Optical microscope used to evaluate the changes of finishing files of ProTaper Gold (F2) and Dia-X ProTaper (D4).

    The change in Deformation of two file systems before and after clinical application and after exposure to Sodium Hypochlorite in root canal system.

    9 months

  • Stereomicroscope and Optical microscope used to evaluate monitor the changes of finishing files of ProTaper Gold (F2) and Dia-X ProTaper (D4).

    The Presence or absence of metal slivering of two file systems before and after clinical application and after exposure to Sodium Hypochlorite in root canal system.

    9 months

Study Arms (4)

ProTaper Gold (F2) - NaOCL

EXPERIMENTAL

ProTaper Files without NaOCL

Diagnostic Test: Finishing files of ProTaper Gold (F2) without effect to NaOCL

ProTaper Gold (F2) + NaOCL

EXPERIMENTAL

ProTaper Files with NaOCL

Diagnostic Test: Finishing files of ProTaper Gold (F2) with effect to NaOCL

Dia-X ProTaper (D4) - NaOCL

EXPERIMENTAL

Dia-X ProTaper (D4) without NaOCL

Diagnostic Test: Finishing files of Dia-X ProTaper (D4) without effect to NaOCL

Dia-X ProTaper (D4) + NaOCL

EXPERIMENTAL

Dia-X ProTaper (D4) with NaOCL

Diagnostic Test: Finishing files of Dia-X ProTaper (D4) with effect to NaOCL

Interventions

Finishing files of ProTaper Gold (F2) without effect to NaOCL

ProTaper Gold (F2) - NaOCL

Finishing files of ProTaper Gold (F2) with effect to NaOCL

ProTaper Gold (F2) + NaOCL

Finishing files of Dia-X ProTaper (D4) without effect to NaOCL

Dia-X ProTaper (D4) - NaOCL

Finishing files of Dia-X ProTaper (D4) without effect to NaOCL

Dia-X ProTaper (D4) + NaOCL

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Mandibular first permanent molars
  • A degree of root canal curvature ranging from 10 to 20 degree taper.

You may not qualify if:

  • Teeth with internal and external resorption
  • Teeth with calcified canals
  • Previously endodontic treated teeth

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dow university of Health Sciences

Karachi, Sindh, Pakistan

Location

Related Publications (1)

  • Zinelis S, Eliades T, Eliades G. A metallurgical characterization of ten endodontic Ni-Ti instruments: assessing the clinical relevance of shape memory and superelastic properties of Ni-Ti endodontic instruments. Int Endod J. 2010 Feb;43(2):125-34. doi: 10.1111/j.1365-2591.2009.01651.x.

MeSH Terms

Conditions

Dental Pulp Diseases

Condition Hierarchy (Ancestors)

Tooth DiseasesStomatognathic Diseases

Study Officials

  • Iqra Kamal, BDS

    Dow University of Health Sciences

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Lecturer/ MDS Post graduate trainee

Study Record Dates

First Submitted

December 8, 2021

First Posted

April 5, 2022

Study Start

January 1, 2018

Primary Completion

December 20, 2021

Study Completion

January 15, 2022

Last Updated

April 5, 2022

Record last verified: 2022-04

Data Sharing

IPD Sharing
Will not share

Locations