Lack of pediatric recruitment ability
Comparison of Tissue Formation in Regenerative Endodontic Procedures and Apexification
Sponsor study identifier
interventional
0
1 country
1
Study Start
February 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2015
Actual (reported)Study Completion
October 2015
Actual (reported)The purpose of our study is to characterize the composition of the hard and soft tissues present after regenerative endodontic procedures in root canals of teeth previously diagnosed with the need for extraction for orthodontic treatment and incomplete root formation. Although the protocol addressed in this study is currently being used in clinical practice, there are no prospective clinical trials investigating its efficacy in stimulating continued root development and the nature of the newly formed tissues.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2015
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2013
Date type not reportedThis date has not been verified as actual or estimated.
February 28, 2013
Actual (reported)March 6, 2013
Actual (reported)October 2015
Actual (reported)October 2015
Actual (reported)Histological identification of the mineralized tissue at the apical third of the root and the adherent cellular layer.
Although we predict histological identification of dentin/odontoblasts (due to the proximity of the apical papilla and associated SCAP stem cells) using our scanning laser confocal microscopy system, our methods are sufficiently sensitive to permit identification of bone/osteoblasts and cementum/cementoblasts as alternative hypotheses.
Following tooth extraction at the 3 month followup visit. Correlation of all data collected from the extracted teeth will occur at the completion of the study at year 5.
Whether stem cells enter the canal space when bleeding is stimulated through manipulation of the apical papilla.
Canal bleeding is evoked during the second treatment visit thirty days following the first treatment. Blood collected by paper points will be saved till the end of the study (year 5) for analysis.
RTC with Triple Antibiotic Study Drug
RTC on contralateral tooth with no study drug
Regenerative Root Canal Therapy using Triple Antibiotic Paste study drug
Endodontic RTC with no study drug
University of Texas Health Science Center
San Antonio, Texas, 78229, United States
Thibodeau B. Case report: pulp revascularization of a necrotic, infected, immature, permanent tooth. Pediatr Dent. 2009 Mar-Apr;31(2):145-8.
Anibal R Diogenes, DDS, PhD
The University of Texas Health Science Center at San Antonio
Dubravko Pavlin, DMD, PhD
The University of Texas Health Science Center at San Antonio
Kenneth M Hargreaves, DDS, PhD
The University of Texas Health Science Center at San Antonio
0 participants (actual enrollment reported by the registry).
First Submitted
February 28, 2013
First Posted
March 6, 2013
Study Start
February 2013
Date type not reportedThis date has not been verified as actual or estimated.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
October 2015
Actual (reported)Study Completion
October 2015
Actual (reported)Last Updated
February 5, 2016
Record last verified: 2016-02
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Source: ClinicalTrials.gov.
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