Malaria Incidence in Infants in Bancoumana, Mali

NCT00508417 | Completed

• 2 other identifiers: 99990719807-I-N198
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

This study, conducted by the Malaria Research and Training Center at the Faculty of Medicine in Bamako and the NIAID will measure the frequency of occurrence of malaria in infants in Bancoumana, Mali. Information from the study will help in planning trials of malaria vaccines. Healthy children from 6 weeks to 6 months of age who live in the Bancoumana health area may be eligible for this study. Candidates are screened with a physical examination and blood tests. Participating children are visited at home for a total of about 17 visits to see if they are well. They come to the clinic every month during the 7-month study for a clinical evaluation, including a blood sample obtained by finger prick to test for malaria. Some of the blood collected may be stored and used for research. Children who become sick with malaria are treated for the disease.

Conditions

Malaria Infection; Malaria Incidence; Anemia

Keywords

Malaria Incidence; Anemia; Clinical Malaria

Eligibility Criteria

• Age: 6 Weeks - 6 Months
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Infants at least six weeks to less than 7 months of age at enrollment
• Known residents of the Bancoumana health area
• Good general health as determined by clinical exam
• Available for the 6-7 months duration of the trial
• Willingness to participate as evidenced by signing of the informed consent or fingerprinting by the parent or guardian

You may not qualify if:

• Social, behavioral, cognitive, or psychiatric condition that in the opinion of the investigator affects the ability of the volunteer or the parent/legal guardian to understand and cooperate with the study protocol
• Participation in an investigational vaccine or drug trial within 30 days of starting this study, or while this study is ongoing
• Infant born to mother with known or suspected HIV/AIDS as determined by the clinician

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

National Institute of Allergy and Infectious Diseases (NIAID), 9000 Rockville Pi

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Duflo B, Balique H, Ranque P, Diallo AN, Brucker G, Alavi H, Prescott N. [Estimation of the impact of the principal diseases in rural Mali]. Rev Epidemiol Sante Publique. 1986;34(6):405-18. French.

  PMID: 3105007 BACKGROUND

• Wagner G, Koram K, McGuinness D, Bennett S, Nkrumah F, Riley E. High incidence of asymptomatic malara infections in a birth cohort of children less than one year of age in Ghana, detected by multicopy gene polymerase chain reaction. Am J Trop Med Hyg. 1998 Jul;59(1):115-23. doi: 10.4269/ajtmh.1998.59.115.

  PMID: 9684638 BACKGROUND

• Moody AH, Chiodini PL. Non-microscopic method for malaria diagnosis using OptiMAL IT, a second-generation dipstick for malaria pLDH antigen detection. Br J Biomed Sci. 2002;59(4):228-31. doi: 10.1080/09674845.2002.11783665.

  PMID: 12572958 BACKGROUND

MeSH Terms

Conditions

Anemia

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: July 27, 2007
• First Posted: July 30, 2007
• Study Start: July 24, 2007
• Study Completion: February 11, 2011
• Last Updated: July 2, 2017

Record last verified: 2011-02-11

Locations

US (1)