NCT00498693

Brief Summary

Specific Aim

  1. 1.To identify specific SNPs of HIF-1 gene related to cardiovascular disease in OSA patients (CVD-OSA)
  2. 2.To assay the functional activity of high risk SNPs of HIF-1 on the transcription of VEGF gene
  3. 3.To confirm that the serum level of VEGF in CVD-OSA patients with high risk SNPs of HIF-1 are higher than CVD-OSA patients without

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2006

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

July 8, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 10, 2007

Completed
Last Updated

January 14, 2009

Status Verified

January 1, 2009

First QC Date

July 8, 2007

Last Update Submit

January 12, 2009

Conditions

Sleep Apnea, Obstructive

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

patients referred sleep center to rule out obstructive sleep apnea

You may qualify if:

  • Severe obstructive sleep apnea (AHI\>=30/hr) age, sex, BMI match control subject

You may not qualify if:

  • Patients were excluded when: (1) refused to participate in this study, (2) had severe obstructive pulmonary disease or active neurological events, (3) enrolled in other studies at the same time

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan Univeristy Hospital

Taipei, Taiwan

RECRUITING

Related Publications (1)

  • Pandit JJ. Structure-function relationships: a breath of fresh air--or just more hot air--in sleep apnoea research? Respiration. 2008;76(1):16-8. doi: 10.1159/000127578. Epub 2008 May 8. No abstract available.

    PMID: 18583924DERIVED

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Condition Hierarchy (Ancestors)

Sleep Apnea SyndromesApneaRespiration DisordersRespiratory Tract DiseasesSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System Diseases

Study Officials

  • Hey-Dong Wu, M.D.

    National Taiwan University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Peilin Lee, M.D.

CONTACT

+886-2-23562905peilin1986@yahoo.com.tw

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 8, 2007

First Posted

July 10, 2007

Study Start

March 1, 2006

Last Updated

January 14, 2009

Record last verified: 2009-01

Locations

TW(1)