Dissection of Differentially Expressed Genes and Pathways in Patients With OSAS Before and After CPAP Treatment

NCT00498732 | Completed DMC

• 1 other identifier: 200701064R
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Specific Aim

1. 1.To verify the differentially expressed genes and pathways between normal and OSA patients, and OSA patients before and after CPAP treatment.
2. 2.To correlate the confirmed genes with the clinical presentations and CPAP effects in another 50 OSAS subjects to validate the altered gene expressions and pathways involved.
3. 3.To establish a cell model to investigate the differentially expressed genes and the putative biological pathways involved in OSA syndrome.

Conditions

Sleep Apnea, Obstructive

Keywords

Obstructive sleep apnea syndrome; CPAP, microarray

Interventions

CPAP DEVICE

CPAP treatment for 4 weeks

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

From patients who were referred to sleep lab for suspect sleep apnea, we selected 50 male patients with age\> 18 y/o. with severe OSAS, which were confirmed with by overnight PSG. All were free from neurologic events, chronic pulmonary disease, active infection and substance abuse. Female patients and patients under 18 y/o were excluded. All 50 subjects were treated with 4-week CPAP. All study subjects were admitted, on the day of baseline measurement and four weeks after CPAP use, for clinical evaluation, blood sampling and PSG. And all anti-hypertensive therapy was remained unchanged during the 4-week follow-up period. Changes of parameters, before and after CPAP treatment, were compared between two groups.

You may qualify if:

• Severe obstructive sleep apnea (AHI\>=30/hr) age, sex, BMI match control subject

You may not qualify if:

• Refused to participate in this study
• Had severe obstructive pulmonary disease or active neurological events
• Enrolled in other studies at the same time

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

Location

MeSH Terms

Conditions

Sleep Apnea, Obstructive; Microcephaly, Primary Autosomal Recessive, 6

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Officials

• Peilin Lee, M.D.

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: July 8, 2007
• First Posted: July 10, 2007
• Study Start: June 1, 2007
• Primary Completion: March 1, 2008
• Study Completion: July 1, 2008
• Last Updated: December 1, 2010

Record last verified: 2010-11

Locations

TW (1)