NCT00498849

Brief Summary

The aim of this study are (1) To genome-wide profile the gene expression patterns of peripheral blood mononuclear cell (PBMC) in patients with obstructive sleep apnea (OSA) (2) To profile the gene expression patterns change before and after treatment with continuous positive airway pressure (CPAP) (3) To correlate the altered gene expression with the severity of the disease and outcome of OSA patients

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2005

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2005

Completed
2.4 years until next milestone

First Submitted

Initial submission to the registry

July 8, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 10, 2007

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2007

Completed
Last Updated

July 10, 2007

Status Verified

January 1, 2005

First QC Date

July 8, 2007

Last Update Submit

July 8, 2007

Conditions

Sleep Apnea, Obstructive

Keywords

Sleep apneaContinuous positive airway pressureMicroarrayPolysomnography

Outcome Measures

Primary Outcomes (1)

  • CPAP effect

    4-week after CPAP treatment

Interventions

CPAPDEVICE

Eligibility Criteria

Age18 Years+
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • healthy control with age \> 18 y/o severe OSA (AHI\>=30/hr) with age\>18 y/o

You may not qualify if:

  • chronic lung disease female refuse to receive CPAP treatment or poor compliant to CPAP neurologic event

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Naitonal Taiwan Univerisity Hospital

Taipei, 100, Taiwan

RECRUITING

MeSH Terms

Conditions

Sleep Apnea, ObstructiveSleep Apnea Syndromes

Condition Hierarchy (Ancestors)

ApneaRespiration DisordersRespiratory Tract DiseasesSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System Diseases

Study Officials

  • Peilin Lee, M.D.

    National Taiwan University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Peilin Leee, M.D.

CONTACT

+886-2-23562905peilin1986@yahoo.com.tw

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 8, 2007

First Posted

July 10, 2007

Study Start

February 1, 2005

Study Completion

December 1, 2007

Last Updated

July 10, 2007

Record last verified: 2005-01

Locations

TW(1)