NCT00497887

Brief Summary

Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4,000

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2006

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

July 6, 2007

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 9, 2007

Completed
Last Updated

October 19, 2010

Status Verified

January 1, 2010

First QC Date

July 6, 2007

Last Update Submit

October 18, 2010

Conditions

AtherosclerosisCoronary ArteriosclerosisCarotid Artery DiseasesGenetic Predisposition to DiseaseBiological Markers

Eligibility Criteria

Age18 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients assigned to coronary angiography

You may qualify if:

  • Patients assigned to coronary angiography

You may not qualify if:

  • Cancer
  • Acute myocardial infarction
  • Inability to give informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

University of Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics

Leipzig, 04103, Germany

RECRUITING

University of Leipzig, Heart Center, Department of Cardiology

Leipzig, 04289, Germany

RECRUITING

Related Publications (5)

  • Teren A, Vogel A, Beutner F, Gielen S, Burkhardt R, Scholz M, Thiery J, Ceglarek U. Relationship between fermented dairy consumption, circulating short-chain acylcarnitines and angiographic severity of coronary artery disease. Nutr Metab Cardiovasc Dis. 2020 Sep 24;30(10):1662-1672. doi: 10.1016/j.numecd.2020.05.031. Epub 2020 Jun 8.

    PMID: 32684363DERIVED

  • Jacobi T, Massier L, Kloting N, Horn K, Schuch A, Ahnert P, Engel C, Loffler M, Burkhardt R, Thiery J, Tonjes A, Stumvoll M, Bluher M, Doxiadis I, Scholz M, Kovacs P. HLA Class II Allele Analyses Implicate Common Genetic Components in Type 1 and Non-Insulin-Treated Type 2 Diabetes. J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgaa027. doi: 10.1210/clinem/dgaa027.

    PMID: 31974565DERIVED

  • Pott J, Schlegel V, Teren A, Horn K, Kirsten H, Bluecher C, Kratzsch J, Loeffler M, Thiery J, Burkhardt R, Scholz M. Genetic Regulation of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Plasma Levels and Its Impact on Atherosclerotic Vascular Disease Phenotypes. Circ Genom Precis Med. 2018 May;11(5):e001992. doi: 10.1161/CIRCGEN.117.001992.

    PMID: 29748315DERIVED

  • Weissgerber A, Scholz M, Teren A, Sandri M, Teupser D, Gielen S, Thiery J, Schuler G, Beutner F. The value of noncoronary atherosclerosis for identifying coronary artery disease: results of the Leipzig LIFE Heart Study. Clin Res Cardiol. 2016 Feb;105(2):172-81. doi: 10.1007/s00392-015-0900-x. Epub 2015 Sep 11.

    PMID: 26362881DERIVED

  • Beutner F, Teupser D, Gielen S, Holdt LM, Scholz M, Boudriot E, Schuler G, Thiery J. Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease. PLoS One. 2011;6(12):e29070. doi: 10.1371/journal.pone.0029070. Epub 2011 Dec 22.

    PMID: 22216169DERIVED

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

serum, plasma, whole blood (DNA), blood cells

MeSH Terms

Conditions

AtherosclerosisCoronary Artery DiseaseCarotid Artery DiseasesGenetic Predisposition to Disease

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular DiseasesCoronary DiseaseMyocardial IschemiaHeart DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesDisease SusceptibilityDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Joachim Thiery, MD PhD

    University of Leipzig

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Joachim Thiery, MD PhD

CONTACT

+49-341-9722201thiery@medizin.uni-leipzig.de

Gerhard Schuler, MD PhD

CONTACT

+49-341-8650schug@medizin.uni-leipzig.de

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 6, 2007

First Posted

July 9, 2007

Study Start

December 1, 2006

Last Updated

October 19, 2010

Record last verified: 2010-01

Locations

DE(2)