Understanding the Genetic and Hereditary Basis of Atherosclerosis
SNPs and Extent of Atherosclerosis (SEA) Study
3 other identifiers
observational
2,763
1 country
4
Brief Summary
Atherosclerosis is a condition that occurs when fatty deposits build up along the inner walls of arteries. New strategies are needed to prevent and treat atherosclerosis. The purpose of this study is to analyze the DNA of participants in two ongoing studies to identify genetic variations responsible for the development of atherosclerosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2006
Longer than P75 for all trials
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2006
CompletedFirst Submitted
Initial submission to the registry
June 23, 2006
CompletedFirst Posted
Study publicly available on registry
June 26, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2012
CompletedNovember 8, 2017
March 1, 2017
5.9 years
June 23, 2006
November 6, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
To estimate the association between common single nucleotide polymorphisms (SNPs) in the human genome and extent of subclinical atherosclerosis among subjects in the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) cohort (N=2,876).
Entire project period.
To estimate the association between potential atherosclerosis SNPs identified in the PDAY cohort and extent of subclinical atherosclerosis among subjects in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort (N=6,577).
Entire project period
To define the haplotypic structure of the genome in the regions of SNPs that are associated with atherosclerosis in PDAY and MESA and to perform additional genotyping necessary for haplotype association studies using both the PDAY and MESA cohorts.
Entire project period.
To disseminate the identity, location, primer sets and allele frequency of the atherosclerosis associated SNPs in PDAY, and those confirmed in MESA, in order to facilitate additional replication and functional studies of the most promising SNPs.
Entire project period.
Eligibility Criteria
Subject enrolled in the Pathobiologic Determinants of Atherosclerosis in Youth (PDAY) study
You may qualify if:
- Participant in PDAY or MESA
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (4)
Cedars-Sinai Health System
Los Angeles, California, 90048, United States
Louisiana State University
New Orleans, Louisiana, 70112, United States
The University of Texas
Houston, Texas, 77225, United States
University of Washington
Seattle, Washington, 98105, United States
Biospecimen
DNA
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David M. Herrington, MD, MHS
Wake Forest University Health Sciences
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 23, 2006
First Posted
June 26, 2006
Study Start
March 1, 2006
Primary Completion
February 1, 2012
Study Completion
February 1, 2012
Last Updated
November 8, 2017
Record last verified: 2017-03