Genetic Factors That Influence Chronic Obstructive Pulmonary Disease in Hispanics

NCT00106470 | Completed

• 2 other identifiers: 1289R01HL073373
• Study Type: observational
• Target: 679
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine genetic factors that influence the development of chronic obstructive pulmonary disease (COPD) in Hispanics, a minority group at high risk for the disease.

Conditions

Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive

Keywords

Chronic Obstructive Pulmonary Disease

Outcome Measures

Primary Outcomes (1)

• Genetic factors that influence the development of COPD in Hispanics.

  Measured through the use of genetic samples

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Families of individuals with physician-diagnosed COPD and smoking-related airflow obstruction who are younger than 71 years.

You may qualify if:

• COPD
• Reduced FEV1 after administration of bronchodilator (less than or equal to 60% of predicted value)
• At least six great-grandparents born in the Central Valley of Costa Rica
• At least one sibling with a history of smoking (10 or more packs per year)

You may not qualify if:

• Chronic respiratory disorder other than COPD (as determined by a questionnaire and high-resolution CT chest scan)
• Severe alpha 1-antitrypsin deficiency

Sponsors & Collaborators

• University of Pittsburgh: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

Hospital Nacional de Niños

San José, Costa Rica

Location

Related Publications (3)

• Hunninghake GM, Weiss ST, Celedon JC. Asthma in Hispanics. Am J Respir Crit Care Med. 2006 Jan 15;173(2):143-63. doi: 10.1164/rccm.200508-1232SO. Epub 2005 Oct 6.

  PMID: 16210666 BACKGROUND

• Brehm JM, Celedon JC. Chronic obstructive pulmonary disease in Hispanics. Am J Respir Crit Care Med. 2008 Mar 1;177(5):473-8. doi: 10.1164/rccm.200708-1274PP. Epub 2007 Nov 20.

  PMID: 18029789 BACKGROUND

• Brehm JM, Hagiwara K, Tesfaigzi Y, Bruse S, Mariani TJ, Bhattacharya S, Boutaoui N, Ziniti JP, Soto-Quiros ME, Avila L, Cho MH, Himes B, Litonjua AA, Jacobson F, Bakke P, Gulsvik A, Anderson WH, Lomas DA, Forno E, Datta S, Silverman EK, Celedon JC. Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease. Thorax. 2011 Dec;66(12):1085-90. doi: 10.1136/thoraxjnl-2011-200017. Epub 2011 Sep 15.

  PMID: 21921092 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Serum

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Juan C. Celedon, MD, DrPH

  University of Pittsburgh

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2005
• First Posted: March 25, 2005
• Study Start: February 1, 2005
• Primary Completion: January 1, 2010
• Study Completion: January 1, 2010
• Last Updated: December 17, 2012

Record last verified: 2012-12

Locations

CO (1)