Active Detection of the Extension of Atherothrombosis in High Risk Coronary Patients
AMERICA
Active Detection and Management of the Extension of Atherothrombosis in High Risk Coronary Patients In Comparison With Standard of Care for Coronary Atherosclerosis: The AMERICA Study
2 other identifiers
interventional
526
1 country
1
Brief Summary
Coronary artery disease is the first cause of death related to atherothrombosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable coronary-artery-disease
Started Sep 2007
Longer than P75 for not_applicable coronary-artery-disease
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 8, 2007
CompletedFirst Posted
Study publicly available on registry
March 9, 2007
CompletedStudy Start
First participant enrolled
September 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2013
CompletedJanuary 22, 2020
January 1, 2020
5.6 years
March 8, 2007
January 17, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
death (all cause) or any ischemic event leading to rehospitalisation or any evidence of organ failure.
death (all cause) or any ischemic event leading to rehospitalisation or any evidence of organ failure.
during the study
Secondary Outcomes (1)
Incidence of each composite of the primary endpoint.
during the study
Study Arms (2)
BA :Active arm
OTHERA strategy of systematic screening of these extra-coronary asymptomatic lesions combined with a specific treatment if needed and an aggressive secondary prevention pharmacological treatment of atherothrombosis
BC: Conservative arm
OTHERConservative medical approach
Interventions
A strategy of systematic screening of these extra-coronary asymptomatic lesions combined with a specific treatment if needed and an aggressive secondary prevention pharmacological treatment of atherothrombosis
Eligibility Criteria
You may qualify if:
- Three vessel disease recently identified recently (\<6 month)
- Accrue coronary syndromes in patients\>75 years old (\<1 month)
You may not qualify if:
- Absence of significant coronary lesions
- Other causes of rise in the troponin level
- Patient\<18 years old
- Pregnant women
- Patient without affiliation to National Social Security
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hopital Pitie-Salpetriere
Paris, 75013, France
Related Publications (1)
Collet JP, Cayla G, Ennezat PV, Leclercq F, Cuisset T, Elhadad S, Henry P, Belle L, Cohen A, Silvain J, Barthelemy O, Beygui F, Diallo A, Vicaut E, Montalescot G; AMERICA Investigators. Systematic detection of polyvascular disease combined with aggressive secondary prevention in patients presenting with severe coronary artery disease: The randomized AMERICA Study. Int J Cardiol. 2018 Mar 1;254:36-42. doi: 10.1016/j.ijcard.2017.11.081. Epub 2018 Jan 28.
PMID: 29407124DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jean-Philippe COLLET, MD PhD
Assistance Publique - Hôpitaux de Paris
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 8, 2007
First Posted
March 9, 2007
Study Start
September 1, 2007
Primary Completion
April 1, 2013
Study Completion
April 1, 2013
Last Updated
January 22, 2020
Record last verified: 2020-01