Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)
HERCET
Randomized, Clinical Trial to Study the Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function, Oxidative Stress and Regenerative Capacity of Endothelial Progenitor Cells in Patients With Coronary Artery Disease
1 other identifier
interventional
30
1 country
1
Brief Summary
Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective properties. The purpose of the present study is to characterize the quality of HDL-cholesterol in patients with coronary artery disease and normal blood HDL-cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-cholesterol in these patients. Additionally, the researchers aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with coronary artery disease and the changes dependent on physical activity of patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable coronary-artery-disease
Started Apr 2007
Shorter than P25 for not_applicable coronary-artery-disease
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2007
CompletedFirst Submitted
Initial submission to the registry
April 4, 2007
CompletedFirst Posted
Study publicly available on registry
April 6, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2008
CompletedAugust 15, 2007
April 1, 2007
April 4, 2007
August 14, 2007
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
vasculoprotective and regenerative functions of HDL-cholesterol before and after 8-weeks of exercise training
Secondary Outcomes (1)
flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound
Interventions
Eligibility Criteria
You may qualify if:
- Coronary artery disease
- Normal HDL-cholesterol levels in blood:
- \> 40 mg/dl (1.03 mmol/L) in males
- \> 50 mg/dl (1.29 mmol/L) in females
You may not qualify if:
- Type 1 or 2 diabetes mellitus
- Acute coronary syndrome
- Unstable angina pectoris
- Myocardial infarction during the last 8 weeks
- Therapy with niacin
- Active infections
- Ventricular arrhythmias
- Systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 95 mmHg
- Cancer
- Pregnant or lactating
- Alcoholism
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hannover Medical School
Hanover, 30625, Germany
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Helmut Drexler, MD
Hannover Medical School
- PRINCIPAL INVESTIGATOR
Ulf Landmesser, MD
Hannover Medical School
- PRINCIPAL INVESTIGATOR
Kristina Sonnenschein, MD
Hannover Medical School
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
April 4, 2007
First Posted
April 6, 2007
Study Start
April 1, 2007
Study Completion
April 1, 2008
Last Updated
August 15, 2007
Record last verified: 2007-04