MRI in Evaluating the Effect of Efaproxiral on the Brain in Patients With Recurrent or Progressive Glioma Enrolled on Clinical Trial NABTT-9806

NCT00433472 | Withdrawn

• 6 other identifiers: NABTT-2002 CDR0000274785U01CA062475P30CA006973NABTT-2002JHOC-NABTT-2002ALLOS-RSR13CT-001i
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

RATIONALE: Diagnostic procedures, such as MRI, may help doctors learn how efaproxiral works in the brain and help plan the best treatment. PURPOSE: This clinical trial is using MRI to evaluate the effect of efaproxiral on the brain in patients with recurrent or progressive glioma receiving treatment on clinical trial NABTT-9806.

Conditions

Brain and Central Nervous System Tumors

Keywords

adult anaplastic oligodendroglioma; adult giant cell glioblastoma; adult anaplastic astrocytoma; recurrent adult brain tumor; adult glioblastoma; adult gliosarcoma

Outcome Measures

Primary Outcomes (5)

• Measurable effect of efaproxiral on the brain as measured by T2 and/or T2* MRI

• Predicted oxygenation changes based on observed T2 MRI changes

• Effects of efaproxiral on T2 and T2* MRI relaxation times of normal areas of the brain

• Baseline oxygen extraction ratios in tumors

• New tumor- or non-tumor-related abnormalities on T2 and T2* MRI

Study Arms (1)

MRI -

OTHER

MRI scan to be complete to look at RSR13 on measurement of T2 and T2\* on MRI Procedure/surgery magnetic resonance imaging (MRI)

Device: magnetic resonance imaging (MRI)

Interventions

magnetic resonance imaging (MRI) DEVICE

MRI scan to be complete to look at RSR13 on measurement of T2 and T2\* on MRI

Also known as: MRI

MRI -

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Recurrent or progressive glioma * Currently enrolled on clinical trial NABTT-9806 PATIENT CHARACTERISTICS: * No severe claustrophobia * No cardiac pacemaker * No MRI-incompatible metallic implant PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins: lead
• National Cancer Institute (NCI): collaborator

MeSH Terms

Conditions

Central Nervous System Neoplasms; Oligodendroglioma; Glioblastoma; Astrocytoma; Brain Neoplasms; Gliosarcoma

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Nervous System Diseases; Glioma; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Brain Diseases; Central Nervous System Diseases

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Larry Kleinberg, MD

  Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Purpose: DIAGNOSTIC
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 8, 2007
• First Posted: February 12, 2007
• Last Updated: July 29, 2015

Record last verified: 2015-07