Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
ARISTOTLE
A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation
1 other identifier
interventional
20,976
40 countries
1108
Brief Summary
The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 atrial-fibrillation
Started Dec 2006
Typical duration for phase_3 atrial-fibrillation
1108 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 18, 2006
CompletedFirst Posted
Study publicly available on registry
December 19, 2006
CompletedStudy Start
First participant enrolled
December 31, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 25, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
May 25, 2011
CompletedResults Posted
Study results publicly available
April 29, 2013
CompletedJuly 3, 2018
May 1, 2018
4.4 years
December 18, 2006
January 25, 2013
June 5, 2018
Conditions
Outcome Measures
Primary Outcomes (2)
Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period
All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period
Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Secondary Outcomes (12)
Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Events of All-Cause Death During the Intended Treatment Period
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated All-Cause Death During the Intended Treatment Period
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
- +7 more secondary outcomes
Other Outcomes (5)
Number of Participants With Adverse Events (AEs), Bleeding AEs, Serious Adverse Events (SAEs), Discontinuations Due to AEs, or Deaths During the Treatment Period
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) During the Treatment Period
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Thrombolysis in Myocardial Infarction (TIMI) During the Treatment Period
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
- +2 more other outcomes
Study Arms (2)
1
ACTIVE COMPARATOR2
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
- Age ≥ 75, previous stroke
- transient ischemic attack (TIA) or Systemic Embolism (SE)
- Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
- Diabetes mellitus or hypertension requiring pharmacological treatment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1111)
Cardiovascular Associates, Pc
Birmingham, Alabama, 35209, United States
Alabama Internal Medicine Pc
Birmingham, Alabama, 35235, United States
Birmingham Heart Clinic P.C.
Birmingham, Alabama, 35235, United States
Heart Center, Inc.
Huntsville, Alabama, 35801, United States
Mobile Heart Specialists, Pc
Mobile, Alabama, 36608, United States
Clara V. Massey, Md
Mobile, Alabama, 36617, United States
Alaska Heart Institute
Anchorage, Alaska, 99508, United States
Internal Medicine Physicians Associates, P.C.
Phoenix, Arizona, 85006, United States
Southwest Heart
Tucson, Arizona, 85710, United States
Southern Arizona Va Health Care System
Tucson, Arizona, 85723, United States
Pima Research Foundation
Tucson, Arizona, 85745, United States
Dr. Rajesh Shroff
Hot Springs, Arkansas, 71913, United States
Mary K. Richards, Md Pa
Little Rock, Arkansas, 72204, United States
Advanced Clinical Reserach Institute
Anaheim, California, 92801, United States
Act/Cardiovascular Research Institute
Beverly Hills, California, 90210, United States
Capitol Interventional Cardiology
Carmichael, California, 95608, United States
Escondido Cardiology Associates, Inc.
Escondido, California, 92025, United States
William D. Bowden, D.O.
Healdsburg, California, 95448, United States
La Mesa Cardiac Center, A Medical Group
La Mesa, California, 91942, United States
Va Greater Los Angeles Healthcare System
Los Angeles, California, 90073, United States
Coastal Cardiology
Mission Viejo, California, 92691, United States
Kenneth W. Carr Md
Oceanside, California, 92056, United States
Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
Palm Springs, California, 92262, United States
Desert Cardiology Consultants Medical Group, Inc
Rancho Mirage, California, 92270, United States
Regional Cardiolody Associates
Sacramento, California, 95819, United States
Northern California Research
Sacramento, California, 95821, United States
Sacramento Heart And Vascular Medical Associates
Sacramento, California, 95825, United States
Arrhythmia Consultants Of The Central Coast Medical Group
Santa Barbara, California, 93105, United States
Northern California Medical Associates
Santa Rosa, California, 95403, United States
Progressive Clinical Research
Vista, California, 92083, United States
Cardivasclular Consultants Medical Group
Walnut Creek, California, 94598, United States
Shiva Heart Center Medical Group
Wildomar, California, 92595, United States
Electrophysiology Associates, Pc
Colorado Springs, Colorado, 80910, United States
Aurora Denver Cardiology Associates, P.C.
Denver, Colorado, 80218, United States
Denver Va Medical Center
Denver, Colorado, 80220, United States
New West Physicians Clinical Research
Golden, Colorado, 80401, United States
South Denver Cardiology Associates Pc
Littleton, Colorado, 80120, United States
Connecticut Clinical Research, Llc
Bridgeport, Connecticut, 06606, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
Cardiology Associates Of New Haven,Pc
Guilford, Connecticut, 06437, United States
The William W. Backus Hospital
Norwich, Connecticut, 06360, United States
William W Backus Hospital
Norwich, Connecticut, 06360, United States
Stamford Therapeutics Consortium
Stamford, Connecticut, 06905, United States
Chase Medical Research, Llc
Waterbury, Connecticut, 06708, United States
Alfieri Cardiology
Newark, Delaware, 19713, United States
George Washington University Medical Faculty Associates
Washington D.C., District of Columbia, 20037, United States
Washington Va Medical Center
Washington D.C., District of Columbia, 20422, United States
Medical Specialist Of The Palm Beach
Atlantis, Florida, 33462, United States
Miami International Cardiology Consultants
Aventura, Florida, 33180, United States
David Charles Mishkel, Md, Pa
Boca Raton, Florida, 33431, United States
The Heart & Vascular Institute Of Florida
Clearwater, Florida, 33756, United States
The Heart And Vascular Institute Of Florida
Clearwater, Florida, 33756, United States
Cardiovascular Specialist Of South Florida
Davie, Florida, 33324, United States
Daytona Heart Group
Daytona Beach, Florida, 32114, United States
Cardiology Associates Of Fort Lauderdale, P.A.
Fort Lauderdale, Florida, 33308, United States
Broward General Medical Center
Fort Lauderdale, Florida, 33316, United States
Florida Heart Associates
Fort Myers, Florida, 33907, United States
Florida Research Network, Llc
Gainesville, Florida, 32605, United States
Healthworx
Hollywood, Florida, 33021, United States
Luis Tami, Md
Hollywood, Florida, 33021, United States
Nature Coast Clinical Research
Inverness, Florida, 34452, United States
St. Vincent'S Ambulatory Care, Inc
Jacksonville, Florida, 32204, United States
Jacksonville Heart Center, Pa
Jacksonville, Florida, 32207, United States
Jacksonville Cardiovascular Center
Jacksonville, Florida, 32216, United States
Jacksonville Center For Clinical Research
Jacksonville, Florida, 32216, United States
St. Luke'S Cardiology
Jacksonville, Florida, 32216, United States
Jacksonville Heart Center, Pa
Jacksonville, Florida, 32258, United States
Jacksonville Heart Center, P.A.
Jacksonville Beach, Florida, 32250, United States
Cvms Research Institute, Llc
Jupiter, Florida, 33458, United States
Ricardo Bedoya, M.D.
Jupiter, Florida, 33458, United States
Melbourne Internal Medicine Associates
Melbourne, Florida, 32901, United States
Miami International Cardiology Consultants
Miami, Florida, 33137-3732, United States
Miami International Cardiology Consultants
Miami, Florida, 33137, United States
Physicians Regional Medical Group
Naples, Florida, 34119, United States
Florida Heart Group
Orlando, Florida, 32803, United States
Alpha Medical Research
Oviedo, Florida, 32765, United States
Cardiology Consultants
Pensacola, Florida, 32501, United States
Niranjan Seshadri, Md
Sarasota, Florida, 34232, United States
Heart & Vascular Center Research, Inc.
Sarasota, Florida, 34239, United States
The Heart And Vascular Institute Of Florida
St. Petersburg, Florida, 33709, United States
Research, Inc.
Vero Beach, Florida, 32960, United States
Cardiovascular Specialits, Pc
Atlanta, Georgia, 30342, United States
Augusta Cardiology Clinic, P.C.
Augusta, Georgia, 30901, United States
Columbus Cardiology Associates Pc
Columbus, Georgia, 31909, United States
Columbus Cardiology Associates,Pc
Columbus, Georgia, 31909, United States
Georgia Heart Specialists, L.L.C.
Covington, Georgia, 30014, United States
Atlanta Institute For Medical Research, Inc
Decatur, Georgia, 30030, United States
Northeast Georgia Heart Center, Pc
Gainesville, Georgia, 30501, United States
Wellstar Cardiovascular Medicine, Pc
Marietta, Georgia, 30060, United States
Fox Valley Clinical Research Center, Llc
Aurora, Illinois, 60504, United States
Nmff
Chicago, Illinois, 60611, United States
Clinical Investigation Specialists, Inc
Gurnee, Illinois, 60031, United States
Loyola University Medical Center
Maywood, Illinois, 60153, United States
Illinois Heart & Lung Research Center, Sc
Normal, Illinois, 61761, United States
Cpt. James A Lovell Federal Health Care Center
North Chicago, Illinois, 60064, United States
Community Clinical Research Center
Anderson, Indiana, 46011, United States
Premier Healthcare, Llc
Bloomington, Indiana, 47403, United States
Elkhart Clinic, Llc
Elkhart, Indiana, 46514, United States
Lutheran Medical Group, Llc
Fort Wayne, Indiana, 46804, United States
Fort Wayne Cardiology
Fort Wayne, Indiana, 46805, United States
St Francis Medical Group - Indiana Heart Physicians
Indianapolis, Indiana, 46237, United States
The Care Group, Llc.
Indianapolis, Indiana, 46290, United States
The Care Group, Llc
Indianapolis, Indiana, 46290, United States
Dali, Sammi
Michigan City, Indiana, 46360, United States
Cardiology Associates, Inc.
South Bend, Indiana, 46601, United States
Mcfarland Clinic Pc
Ames, Iowa, 50010, United States
Midwest Cardiology Associates , P.C.
Overland Park, Kansas, 66209, United States
Central Cardiology Assoc.
Elizabethtown, Kentucky, 42701, United States
New Lexington Clinic, P.S.C.
Lexington, Kentucky, 40504, United States
Va Medical Center
Louisville, Kentucky, 40202, United States
Norton Cardiovascular Associates
Louisville, Kentucky, 40205, United States
Owensboro Heart & Vascular
Owensboro, Kentucky, 42303, United States
Alexandria Cardiology Clinic
Alexandria, Louisiana, 71301, United States
Cardiovascular Institute Of The South
Houma, Louisiana, 70360, United States
Smith, Patel & Amkieh, Llc
Lacombe, Louisiana, 70445, United States
Imperial Calcasieu Medical Group, Llp
Lake Charles, Louisiana, 70601, United States
Cardiology Center, Llc
Marrero, Louisiana, 70072, United States
Cardiology Associates
Shreveport, Louisiana, 71105, United States
Louisiana Heart Center
Slidell, Louisiana, 70458, United States
Medical Research Inst, Inc
Slidell, Louisiana, 70458, United States
Medical Research Institute, Inc
Slidell, Louisiana, 70458, United States
Ventura Cardio. Cond. Med. Group, Inc.
Ventura, Louisiana, 93003, United States
Central Maine Heart & Vascular Institute
Lewiston, Maine, 04240, United States
Midatlantic Cardiovascular Associates, P.A.
Baltimore, Maryland, 21204, United States
Midatlantic Cardiovascular Associates, Pa
Baltimore, Maryland, 21208, United States
Midatlantic Cardiovascular Associates, P.A.
Baltimore, Maryland, 21218, United States
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, 21224-2735, United States
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, 21224, United States
Franklin Square Hospital
Baltimore, Maryland, 21237, United States
Midatlantic Cardiovascular Associates, P.A.
Baltimore, Maryland, 21237, United States
Midatlantic Cardiovascular Associates, Pa
Baltimore, Maryland, 21237, United States
Midatlantic Cardiovascular Associates, Pa
Bel Air, Maryland, 21014, United States
Cardiovascular Specialists Of Central Maryland, P.A.
Columbia, Maryland, 21044, United States
Clinical Associates Research
Reisterstown, Maryland, 21136, United States
Midatlantic Cardiovascular Associates, Pa
Westminster, Maryland, 21157, United States
Burlington Medical Associates
Billerica, Massachusetts, 01821, United States
Caritas St. Elizabeth'S Medical Center
Boston, Massachusetts, 02135, United States
Lahey Clinic Medical Center
Burlington, Massachusetts, 01805, United States
Neccr Internal Medicine & Cardiology Associates,Llc
Fall River, Massachusetts, 02720, United States
Pentucket Medical Associates
Haverhill, Massachusetts, 01830-6278, United States
Pentucket Medical Associates
Haverhill, Massachusetts, 01830, United States
Charles River Medical Associates
Natick, Massachusetts, 01760, United States
Great Lakes Heart Center Of Alpena
Alpena, Michigan, 49707, United States
Henry Ford Hospital
Detroit, Michigan, 48202, United States
Thoracic And Cardiovascular Healthcare Foundation
Lansing, Michigan, 48910, United States
Advanced Cardiovascular Health Specialists, Pc
Livonia, Michigan, 48154, United States
Michigan Heart And Vascular Specialists
Petoskey, Michigan, 49770, United States
William Beaumont Hospital
Royal Oak, Michigan, 48073, United States
Michigan Heart, P.C.
Ypsilanti, Michigan, 48197, United States
Minneapolis Va Medical Center
Minneapolis, Minnesota, 55417, United States
University Of Minnesota
Minneapolis, Minnesota, 55455, United States
North Memorial Health Care
Robbinsdale, Minnesota, 55422, United States
Olive Branch Family Medical Center
Olive Branch, Mississippi, 38654, United States
Tupelo Neurology Clinic, Pa
Tupelo, Mississippi, 38801, United States
University Of Missouri
Columbia, Missouri, 65212, United States
Truman Medical Center
Kansas City, Missouri, 64108, United States
Saint Luke'S Lipid And Diabetes Research Center
Kansas City, Missouri, 64111, United States
Internal Medical Associates of Grand Island, P.C
Grand Island, Nebraska, 68803-4311, United States
Internal Medical Associates Of Grand Island, P.C
Grand Island, Nebraska, 68803, United States
Nebraska Heart Institute
Hastings, Nebraska, 68901, United States
Va Southern Nevada Healthcare System
Las Vegas, Nevada, 89106, United States
Comprehensive Clinical Research
Berlin, New Jersey, 08009, United States
Cardiovascular Associates Of The Delware Valley, P.A.
Elmer, New Jersey, 08318, United States
Cardiovascular Associates Of The Delaware Valley, P.A.
Haddon Heights, New Jersey, 08035, United States
Princeton Medical Institute
Princeton, New Jersey, 08540, United States
Cardio Assoc Of Del Val, P.A.
Sewell, New Jersey, 08080, United States
Central New Jersey Cardiology
South Plainfield, New Jersey, 07080, United States
Abq Health Partners, Llc
Albuquerque, New Mexico, 87012, United States
University Of New Mexico/University Hospital
Albuquerque, New Mexico, 87131-0001, United States
University Of New Mexico/University Hospital
Albuquerque, New Mexico, 87131, United States
Albany Assoc. In Cardiology
Albany, New York, 12205, United States
Albany Associates In Cardiology
Albany, New York, 12205, United States
Cardiology Associates, Pc
Binghamton, New York, 13905, United States
Buffalo Heart Group, Llp
Buffalo, New York, 14215-1145, United States
Bruce L. Platt Md, Pc
Buffalo, New York, 14215, United States
Bruce L. Platt, Md
Buffalo, New York, 14215, United States
Buffalo Heart Group, Llp
Buffalo, New York, 14215, United States
Heart Care Center, P.C.
East Syracuse, New York, 13057, United States
Huntington Hospital
Huntington, New York, 11743, United States
Sjh Cardiology Associates
Liverpool, New York, 13088, United States
Long Island Heart Associates
Mineola, New York, 11501, United States
Saratoga Cardiology Associates, Pc
Saratoga Springs, New York, 12866, United States
Office Of Dr. Kozinn
Williamsville, New York, 14221, United States
Suburban Cardiology
Williamsville, New York, 14221, United States
Asheville Cardiology Associates
Asheville, North Carolina, 28803, United States
Kernodle Clinic, Inc.
Burlington, North Carolina, 27215, United States
Carolina Cardiology Associates, Pa
High Point, North Carolina, 27262, United States
Pinehurst Medical Center, Inc
Pinehurst, North Carolina, 28374, United States
Lillestol Research Llc
Fargo, North Dakota, 58103, United States
Akron Cardiology Consultants
Akron, Ohio, 44304, United States
Christopher M. Johnson, D.O.
Bucyrus, Ohio, 44820, United States
Christopher M. Johnson, D.O.
Bucyrus, Ohio, OHIO, United States
Community Health Care, Inc.
Canal Fulton, Ohio, 44614, United States
Cardiology Associates
Canton, Ohio, 44710, United States
The Carl & Edyth Lindner Center For R&E At The Christ Hosp
Cincinnati, Ohio, 45219, United States
Toledo Cardiology Consultants
Toledo, Ohio, 43608, United States
Family Practice Center Of Wadsworth, Inc.
Wadsworth, Ohio, 44281, United States
Jack C. Va Medical Center
Muskogee, Oklahoma, 74401, United States
Cor Clinical Research, Llc
Oklahoma City, Oklahoma, 73103, United States
University Of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
Plaza Medical Group, Pc
Oklahoma City, Oklahoma, 73112, United States
Oklahoma Heart Hospital Physicians
Oklahoma City, Oklahoma, 73120, United States
South Oklahoma Heart Research
Oklahoma City, Oklahoma, 73135, United States
Eminence Research, Llc
Oklahoma City, Oklahoma, 73139, United States
Castlerock Clinical Research Consultants, Llc
Tulsa, Oklahoma, 74136, United States
St. Charles Health System, Inc.
Bend, Oregon, 97701, United States
St. Charles Health System, Inc
Bend, Oregon, 97701, United States
Oregon Medical Group - Clinical Research
Eugene, Oregon, 97401, United States
Hillsboro Cardiology Pc
Hillsboro, Oregon, 97123, United States
Rogue Valley Physicians - Clinical Research Group
Medford, Oregon, 97504, United States
Abington Medical Specialists
Abington, Pennsylvania, 19001, United States
Blair Medical Associates, Inc.
Altoona, Pennsylvania, 16602, United States
Heritage Cardiology Assoc.
Camp Hill, Pennsylvania, 17011, United States
Central Bucks Cardiology
Doylestown, Pennsylvania, 18901, United States
Internal Medicine And Lipid Mgmt.
Erie, Pennsylvania, 16509, United States
Kandra, Fierer, Kuskin Associates
Harrisburg, Pennsylvania, 17112, United States
Pivotal Clinical Research, Llc
Hatfield, Pennsylvania, 19440, United States
Lycoming Internal Medicine Inc.
Jersey Shore, Pennsylvania, 17740, United States
Guthrie Clinic Ltd.
Sayre, Pennsylvania, 18840, United States
Guthrie Medical Group, P.C.
Sayre, Pennsylvania, 18840, United States
Preferred Primary Care Physicians
Uniontown, Pennsylvania, 15401, United States
West Chester Cardiology, Pc
West Chester, Pennsylvania, 19380, United States
Cardiology Consultants Of Philadelphia
Yardley, Pennsylvania, 19067, United States
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
Southeastern Research Associates, Inc
Anderson, South Carolina, 29621, United States
Lowcountry Medical Group, Llc
Beaufort, South Carolina, 29906, United States
Lowcountry Medical Group
Beaufort, South Carolina, 29906, United States
Medical University Of South Carolina
Charleston, South Carolina, 29425, United States
Columbia Heart Clinic
Columbia, South Carolina, 29203, United States
Upstate Cardiology
Greenville, South Carolina, 29607, United States
Internal Medicine Of Greer
Greer, South Carolina, 29650, United States
Palmetto Nephrology Pa
Orangeburg, South Carolina, 29118, United States
S. Carolina Pharmaceutical Research
Spartanburg, South Carolina, 29303, United States
Avera Medical Associates Clinic
Pierre, South Dakota, 57501, United States
Holston Medical Group
Bristol, Tennessee, 37620, United States
Holston Medical Group
Kingsport, Tennessee, 37660, United States
Knoxville Heart Group
Knoxville, Tennessee, 37916, United States
Volunteer Research Group
Knoxville, Tennessee, 37920-1502, United States
Volunteer Research Group
Knoxville, Tennessee, 37920, United States
Tennessee Center For Clinical Trials
Tullahoma, Tennessee, 37388, United States
Amarillo Heart Clinical Research Institute Inc.
Amarillo, Texas, 79106, United States
Corsicana Medical Research, Pllc
Corsicana, Texas, 75110, United States
Soltero Cardiovascular Research Center
Dallas, Texas, 75226, United States
Heartplace
Dallas, Texas, 75230, United States
Heart Center Of North Texas
Fort Worth, Texas, 76104, United States
Center For Atrial Fibrillation
Houston, Texas, 77030, United States
The Methodist Hospital Neurology Institute
Houston, Texas, 77030, United States
The Methodist Hospital
Houston, Texas, 77030, United States
The University Of Texas Md Anderson Cancer Center
Houston, Texas, 77030, United States
Northwest Houston Cardiology, Pa
Houston, Texas, 77065, United States
Northwest Houston Cardiology, Pa
Houston, Texas, 77070, United States
Francisco R. Maislos
Houston, Texas, 77074, United States
Woodlands North Houston Heart Center
Houston, Texas, 77090, United States
Regional Medical Center And Diagnostic Clinics
Humble, Texas, 77338, United States
Wilford Hall Medical Center
Lackland Air Force Base, Texas, 78236-9908, United States
Wilford Hall Medical Center
Lackland Air Force Base, Texas, 78236, United States
Dcol Center For Clinical Research
Longview, Texas, 75605, United States
North Dallas Research Associates
McKinney, Texas, 75069, United States
Legacy Heart Center
Plano, Texas, 75024, United States
North Texas Medical Research
Plano, Texas, 75093, United States
Bhs Specialty Network, Inc
San Antonio, Texas, 78217, United States
Covenant Clinical Research, Pa
San Antonio, Texas, 78229, United States
Star Clinical Trails
San Antonio, Texas, 78229, United States
Edward Balli, Md, Pa
Seguin, Texas, 78155, United States
Northwest Heart Center
Tomball, Texas, 77375, United States
Tyler Cardiovascular Consultants
Tyler, Texas, 75701, United States
The Univ. Of Texas Health Science Ctr. At Tyler
Tyler, Texas, 75708, United States
University Of Texas Health Science Center At Tyler
Tyler, Texas, 75708, United States
Utah Cardiology P.C
Layton, Utah, 84041, United States
Sentara York Clinical Research
Norfolk, Virginia, 23510, United States
Medical Research Initiatives
Richmond, Virginia, 23220, United States
Roanoke Heart Institute, Plc
Roanoke, Virginia, 24014, United States
Cardiovascular Associates
Virginia Beach, Virginia, 23454, United States
Daniel W. Gottlieb, Md, Ps
Burien, Washington, 98166, United States
Daniel William Gottlieb, Md
Burien, Washington, 98166, United States
Rockwood Clinic Research Cent.
Spokane, Washington, 99202, United States
Walla Walla Clinic
Walla Walla, Washington, 99362, United States
Lynn N. Smith, Md
Lewisburg, West Virginia, 24901, United States
Cardiology Associates Of Green Bay Ltd-Bellin Hospital
Green Bay, Wisconsin, 54301, United States
St. Mary'S Hospital
Madison, Wisconsin, 53715, United States
St.Mary'S Hospital
Madison, Wisconsin, 53715, United States
Aurora Health Care
Milwaukee, Wisconsin, 53215, United States
Medical College Of Wisconsin
Milwaukee, Wisconsin, 53226, United States
Cardiology Assc. Of Waukesha
Waukesha, Wisconsin, 53188, United States
Local Institution
Adrogué, Buenos Aires, 1846, Argentina
Local Institution
Bahía Blanca, Buenos Aires, B8000FTD, Argentina
Local Institution
Ciudad Autonoma de Buenos Aire, Buenos Aires, CI094AAD, Argentina
Local Institution
Ciudad Autonoma de, Buenos Aires, 1180, Argentina
Local Institution
Ciudad Autonoma, Buenos Aires, 1128AAD, Argentina
Local Institution
Ciudad Autonoma, Buenos Aires, 1128, Argentina
Local Institution
Ciudad Autonoma, Buenos Aires, 1426 EGR, Argentina
Local Institution
Ciudad Autonoma, Buenos Aires, C1426 EGR, Argentina
Local Institution
Ciudad Autonoma, Buenos Aires, CP1425A WC, Argentina
Local Institution
Ciudad Autonoma, Buenos Aires, CP1425AWC, Argentina
Local Institution
Coronel Suárez, Buenos Aires, B7540GHD, Argentina
Local Institution
Haedo, Buenos Aires, B1706AJU, Argentina
Local Institution
Junín, Buenos Aires, 6000, Argentina
Local Institution
La Plata, Buenos Aires, 1900, Argentina
Local Institution
La Plata, Buenos Aires, 1902, Argentina
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La Plata, Buenos Aires, B1900AXI, Argentina
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Mar del Plata, Buenos Aires, 7600, Argentina
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Merlo, Buenos Aires, 1722, Argentina
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Merlo, Buenos Aires, B1722COV, Argentina
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Olivos, Buenos Aires, 1602, Argentina
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Quilmes, Buenos Aires, 1878, Argentina
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Ramos Mejía, Buenos Aires, 1706, Argentina
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Ramos Mejía, Buenos Aires, B1704ESN, Argentina
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Ramos Mejía, Buenos Aires, B1704ETD, Argentina
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San Justo, Buenos Aires, 1754, Argentina
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San Martín, Buenos Aires, 1650, Argentina
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San Nicolás de los Arroyos, Buenos Aires, 2900, Argentina
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Zárate, Buenos Aires, 2800, Argentina
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Zárate, Buenos Aires, B2800DGH, Argentina
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Córdoba, Córdoba Province, 5000, Argentina
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Cipolletti, Río Negro Province, 8324, Argentina
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Rosario, Santa Fe Province, 2000, Argentina
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Rosario, Santa Fe Province, S2000 CVD, Argentina
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Rosario, Santa Fe Province, S2000CVB, Argentina
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Rosario, Santa Fe Province, S2000CVD, Argentina
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Rosario, Santa Fe Province, S2001ODA, Argentina
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San Miquel de Tucuman, Tucumán Province, 4000, Argentina
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Buenos Aires, 1119, Argentina
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Buenos Aires, 1181, Argentina
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Buenos Aires, 1280, Argentina
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Buenos Aires, C1280AEB, Argentina
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Buenos Aires, C1426ANZ, Argentina
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Córdoba, 5000, Argentina
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Córdoba, X5000EPU, Argentina
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Córdoba, X5003DCE, Argentina
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Córdoba, X5008KKF, Argentina
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Salta, 4400, Argentina
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San Miguel de Tucumán, T4000NIL, Argentina
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Santa Fe, 3000, Argentina
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Coffs Harbour, New South Wales, 2450, Australia
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Concord, New South Wales, 2139, Australia
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Gosford, New South Wales, 2250, Australia
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Kogarah, New South Wales, 2217, Australia
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Miranda, New South Wales, 2228, Australia
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Auchenflower, Queensland, 4066, Australia
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Brisbane, Queensland, 4032, Australia
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Caboolture, Queensland, 4510, Australia
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Herston, Queensland, 4029, Australia
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Kippa-Ring, Queensland, 4021, Australia
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Nambour, Queensland, 4560, Australia
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Sherwood, Queensland, 4075, Australia
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Adelaide, South Australia, SA 5000, Australia
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Ashford, South Australia, 5035, Australia
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Bedford Park, South Australia, 5042, Australia
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Woodville, South Australia, 5011, Australia
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Box Hill, Victoria, 3128, Australia
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Dandenong, Victoria, 3175, Australia
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Geelong, Victoria, 3220, Australia
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Fremantle, Western Australia, 6160, Australia
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Joondalup, Western Australia, 6027, Australia
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Graz, 8036, Austria
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Oberpullendorf, 7350, Austria
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Vienna, 1160, Austria
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Aalst, 9300, Belgium
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Antwerp, 2020, Belgium
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Antwerp, 2060, Belgium
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Arlon, 6700, Belgium
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Bruges, 8000, Belgium
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Brussels, 1090, Belgium
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Dillingen, 66763, Belgium
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Genk, 3600, Belgium
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Ghent, 9000, Belgium
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Gilly, 6060, Belgium
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Hasselt, 3500, Belgium
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Huy, 4500, Belgium
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Kortrijk, 8500, Belgium
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Menen, 8930, Belgium
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Mol, 2400, Belgium
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Montegnée, 4420, Belgium
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Verviers, 4800, Belgium
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Woluwe-Saint-Lambert, 1200, Belgium
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Yvoir, 5530, Belgium
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Salvador, Estado de Bahia, 40144-900, Brazil
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Salvador, Estado de Bahia, 40144, Brazil
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Salvador, Estado de Bahia, 41810-010, Brazil
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Salvador, Estado de Bahia, 41810, Brazil
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Belo Horzonte, Minas Gerais, 30150-221, Brazil
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Belo Horzonte, Minas Gerais, 30150, Brazil
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Juiz de Fora, Minas Gerais, 36021-630, Brazil
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Juiz de Fora, Minas Gerais, 36021, Brazil
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Uberaba, Minas Gerais, 38056 055, Brazil
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Uberlândia, Minas Gerais, 38400-299, Brazil
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Uberlândia, Minas Gerais, 38400, Brazil
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Campina Grande do Sul, Paraná, 83430-000, Brazil
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Campina Grande do Sul, Paraná, 83430, Brazil
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Curitiba, Paraná, 80010-030, Brazil
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Curitiba, Paraná, 80010, Brazil
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Curitiba, Paraná, 80730-150, Brazil
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Curitiba, Paraná, 80730, Brazil
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Londrina, Paraná, 86010-450, Brazil
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Londrina, Paraná, 86010, Brazil
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Belém, Pará, 66087-660, Brazil
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Belém, Pará, 66087, Brazil
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Natal, Rio Grande do Norte, 59020-100, Brazil
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Natal, Rio Grande do Norte, 59020, Brazil
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Porte Alegre, Rio Grande do Sul, 90610-000, Brazil
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Porte Alegre, Rio Grande do Sul, 90610, Brazil
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Porte Alegre, Rio Grande do Sul, 90880-480, Brazil
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Porte Alegre, Rio Grande do Sul, 90880480, Brazil
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Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
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Porto Alegre, Rio Grande do Sul, 90020, Brazil
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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Porto Alegre, Rio Grande do Sul, 90035, Brazil
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Porto Alegre, Rio Grande do Sul, 90620-001, Brazil
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Porto Alegre, Rio Grande do Sul, 90620, Brazil
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Porto Alegre, Rio Grande do Sul, 91350-280, Brazil
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Porto Alegre, Rio Grande do Sul, 91350, Brazil
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Blumenau, Santa Catarina, 89010-500, Brazil
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Blumenau, Santa Catarina, 89010, Brazil
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São José, Santa Catarina, 88103-450, Brazil
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São José, Santa Catarina, 88103, Brazil
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Botucatu, São Paulo, 18618-000, Brazil
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Botucatu, São Paulo, 18618, Brazil
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Campinas, São Paulo, 13059-740, Brazil
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Campinas, São Paulo, 13059, Brazil
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Marília, São Paulo, 17515-000, Brazil
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Marília, São Paulo, 17515-460, Brazil
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Marília, São Paulo, 17515, Brazil
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Marília, São Paulo, 17519-000, Brazil
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Marília, São Paulo, 17519, Brazil
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San Jose Do Rio Preto, São Paulo, 15090-000, Brazil
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San Jose Do Rio Preto, São Paulo, 15090, Brazil
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Santo André, São Paulo, 09190-610, Brazil
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Santo André, São Paulo, 09190, Brazil
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São José do Rio Preto, São Paulo, 15015-210, Brazil
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São José do Rio Preto, São Paulo, 15015-750, Brazil
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São José do Rio Preto, São Paulo, 15015, Brazil
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Rio de Janeiro, 20551-030, Brazil
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Rio de Janeiro, 20551, Brazil
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Rio de Janeiro, 22251-030, Brazil
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Rio de Janeiro, 22251, Brazil
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São Paulo, 01221-900, Brazil
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São Paulo, 01221, Brazil
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São Paulo, 01322-001, Brazil
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São Paulo, 01322, Brazil
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São Paulo, 01323-001, Brazil
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São Paulo, 01323-010, Brazil
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São Paulo, 01323, Brazil
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São Paulo, 04012-180, Brazil
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São Paulo, 04012, Brazil
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São Paulo, 04024-002, Brazil
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São Paulo, 04024, Brazil
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São Paulo, 04038-031, Brazil
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São Paulo, 04038, Brazil
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São Paulo, 08270-070, Brazil
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São Paulo, 08270, Brazil
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Calgary, Alberta, T2E 7C5, Canada
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Edmonton, Alberta, T56-3NJ, Canada
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Edmonton, Alberta, T5X 3N5, Canada
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Edmonton, Alberta, T6G 2B7, Canada
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Edmonton, Alberta, TSA 4L8, Canada
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Burnaby, British Columbia, V5G 1T4, Canada
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Nanaimo, British Columbia, V9R 3G9, Canada
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New Westminster, British Columbia, V3L 3W4, Canada
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North Vancouver, British Columbia, V7N 4M2, Canada
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Victoria, British Columbia, V8R 4R2, Canada
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Winnipeg, Manitoba, R2V 4W3, Canada
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Bathurst, New Brunswick, E2A 4X7, Canada
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Mount Pearl, Newfoundland and Labrador, A1N 1W7, Canada
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St. John's, Newfoundland and Labrador, A1A 3R5, Canada
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St. John's, Newfoundland and Labrador, A1B 3V6, Canada
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St. John's, Newfoundland and Labrador, A1E 2C2, Canada
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Brampton, Ontario, L6Z 4N5, Canada
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Burlington, Ontario, L7M 4Y1, Canada
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Cambridge, Ontario, N1R 6V6, Canada
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Cambridge, Ontario, N1R 7R1, Canada
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Greater Sudbury, Ontario, P3C 5K7, Canada
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Greater Sudbury, Ontario, P3C5K7, Canada
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Greater Sudbury, Ontario, P3E 2N8, Canada
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Greater Sudbury, Ontario, P3E 3B8, Canada
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Hamilton, Ontario, L8L 2X2, Canada
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London, Ontario, N6G 2V2, Canada
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Mississauga, Ontario, L5B 4A2, Canada
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Newmarket, Ontario, L3Y 5G8, Canada
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Newmarket, Ontario, L3Y 8C3, Canada
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Niagara Falls, Ontario, L2E 7H1, Canada
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Niagara Falls, Ontario, L2E7H1, Canada
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North Bay, Ontario, P1B 2H3, Canada
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Oshawa, Ontario, L1J 2J9, Canada
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Oshawa, Ontario, L1J 2K1, Canada
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Ottawa, Ontario, K1Y 4E9, Canada
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Ottawa, Ontario, K1Y 4W7, Canada
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Sarnia, Ontario, N7T 4X3, Canada
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Scarborough Village, Ontario, M1B 5N1, Canada
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Toronto, Ontario, M5B 1W8, Canada
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Toronto, Ontario, M9W 4L6, Canada
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Weston, Ontario, M9N 1W4, Canada
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Charlottetown, Prince Edward Island, C1A 5Y9, Canada
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Drummondville, Quebec, J2B 7T1, Canada
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Greenfield Park, Quebec, J4V 2G8, Canada
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Lachine, Quebec, H8S 2E4, Canada
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Lévis, Quebec, G6V 4Z5, Canada
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Longueuil, Quebec, J4K 1C8, Canada
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Longueuil, Quebec, J4N 0C9, Canada
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Longueuil, Quebec, J4N 1C2, Canada
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Montreal, Quebec, H1T 1C8, Canada
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Montreal, Quebec, H2W 1T8, Canada
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Montreal, Quebec, H3A 1A1, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, W3R-153, Canada
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Pointe-Claire, Quebec, H9R 3J1, Canada
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Québec, Quebec, G1J 1Z6, Canada
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Saint-Lambert, Quebec, J4P 2H4, Canada
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Ste-Foy, Quebec, G1W 4R4, Canada
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Saskatoon, Saskatchewan, S7L OY7, Canada
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Osorno, Los Lagos Region, 5311089, Chile
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Osorno, Los Lagos Region, 5311523, Chile
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Temuco, Región de la Araucanía, 4781156, Chile
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Temuco, Región de la Araucanía, 4781176, Chile
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Temuco, Región de Valparaíso, 4781173, Chile
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Viña del Mar, Región de Valparaíso, 2570017, Chile
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Santiago, Santiago Metropolitan, 7500520, Chile
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Santiago, Santiago Metropolitan, 7500922, Chile
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Santiago, Santiago Metropolitan, 8330074, Chile
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Beijing, Beijing Municipality, 100001, China
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Beijing, Beijing Municipality, 100020, China
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Beijing, Beijing Municipality, 100050, China
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Beijing, Beijing Municipality, 100088, China
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Beijing, Beijing Municipality, 100101, China
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Beijing, Beijing Municipality, 100853, China
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Lanzhou, Gansu, 730000, China
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Lanzhou, Gansu, 730030, China
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Guangzhou, Guangdong, 510080, China
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Guangzhou, Guangdong, 510120, China
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Shijiazhuang, Hebei, 050000, China
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Daqing, Heilongjiang, 163001, China
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Haerbin, Heilongjiang, 150001, China
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Haerbin, Heilongjiang, 150086, China
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Wuhan, Hubei, 430060, China
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Changsha, Hunan, 410000, China
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Hangzhou, Jiangsu, 310009, China
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Nanjing, Jiangsu, 210029, China
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Dalian, Liaoning, 116011, China
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Dalian, Liaoning, 116021, China
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Dalian, Liaoning, 116027, China
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Shenyang, Liaoning, 110003, China
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Shenyang, Liaoning, 110016, China
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Jinan, Shandong, 250012, China
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Jinan, Shandong, 250033, China
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Qingdao, Shandong, 266011, China
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Shanghai, Shanghai Municipality, 100037, China
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Shanghai, Shanghai Municipality, 200003, China
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Shanghai, Shanghai Municipality, 200011, China
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Shanghai, Shanghai Municipality, 200025, China
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Shanghai, Shanghai Municipality, 200031, China
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Shanghai, Shanghai Municipality, 200080, China
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Shanghai, Shanghai Municipality, 200233, China
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Shanghai, Shanghai Municipality, 200433, China
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Chengdu, Sichuan, 610041, China
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Chongqing, Sichuan, 400010, China
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Hangzhou, Zhejiang, 310009, China
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Medellín, Antioquia, Colombia
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Barranquilla, XXXXX, Colombia
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Barranquilla, Colombia
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Bogotá, 000, Colombia
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Bogotá, Colombia
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Cali, Colombia
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Medellín, Colombia
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Boskovice, 680 21, Czechia
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Brno, 625 00, Czechia
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Brno-Malomerice, 614 00, Czechia
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Ivančice, 664 91, Czechia
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Kladno, 272 59, Czechia
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Litomyšl, 570 14, Czechia
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Městec Králové, 289 03, Czechia
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Ostrava, 70852, Czechia
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Prague, 128 08, Czechia
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Prague, 158 00, Czechia
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Příbram, 261 01, Czechia
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Ústí nad Orlicí, 562 18, Czechia
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Arhus C, 8000, Denmark
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Copenhagen, 2100, Denmark
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Esbjerg, 6700, Denmark
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Frederiksberg, 2000, Denmark
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Frederikssund, 3600, Denmark
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Gentofte Municipality, 2900, Denmark
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Haderslev, 6100, Denmark
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Hellerup, 2900, Denmark
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Herlev, 2730, Denmark
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Herning, 7400, Denmark
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Hillerød, 3400, Denmark
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Hvidovre, 2650, Denmark
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Kolding, 6000, Denmark
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Odense, 5000, Denmark
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Silkeborg, 8600, Denmark
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Slagelse, 4200, Denmark
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Svendborg, 5700, Denmark
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Helsinki, 00280, Finland
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Helsinki, FI-00280, Finland
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Hus, 00029, Finland
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Jyväskylä, 40100, Finland
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Kemi, 94100, Finland
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Oulu, 90100, Finland
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Pori, 28120, Finland
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Tampere, 33100, Finland
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Amiens, 80054, France
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Bordeaux, 33075, France
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Brest, 29609, France
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Grenoble, 38043, France
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La Seyne-sur-Mer, 83500, France
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Paris, 75018, France
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Six-Fours-les-Plages, 83140, France
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Aachen, 52074, Germany
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Bad Krozingen, 79189, Germany
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Bad Neustadt/ Salle, 97616, Germany
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Bad Oeynhausen, 32545, Germany
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Berlin, 10787, Germany
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Berlin, 10789, Germany
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Berlin, 12043, Germany
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Berlin, 13353, Germany
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Berlin, 14050, Germany
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Betzdorf, 57518, Germany
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Bochum, 44789, Germany
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Bochum, 44791, Germany
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Bonn, 53127, Germany
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Coburg, 96450, Germany
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Dillingen, 66763, Germany
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Dresden, 01099, Germany
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Duisburg, 47139, Germany
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Essen, 45122, Germany
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Frankfurt am Main, 60594, Germany
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Göttingen, 37075, Germany
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Halle, 06120, Germany
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Hanover, 30625, Germany
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Heidelberg, 69115, Germany
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Heidelberg, 69120, Germany
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Kassel, 34121, Germany
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Köpenick, 12559, Germany
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Lahr, 77933, Germany
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Ludwigshafen, 67063, Germany
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Ludwigshafen, 67073, Germany
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Mannheim, 68167, Germany
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Marburg, 35043, Germany
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München, 80636, Germany
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München, 81545, Germany
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München, 81675, Germany
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Osnabrück, 49076, Germany
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Regensburg, 93053, Germany
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Riesa, D-01587, Germany
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Rostiock, 18057, Germany
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Trier, 54292, Germany
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Waren, 17192, Germany
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Witten, 58455, Germany
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Wolmirstedt, 39326, Germany
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Worms, 67550, Germany
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Hong Kong, Hong Kong
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Shatin, Hong Kong
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Budapest, 1023, Hungary
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Budapest, 1032, Hungary
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Budapest, 1085, Hungary
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Budapest, 1096, Hungary
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Budapest, 1125, Hungary
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Debrecen, 4032, Hungary
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Dunaújváros, 2400, Hungary
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Győr, 9023, Hungary
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Gyula, 5700, Hungary
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Hódmezővásárhely, 6800, Hungary
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Komárom, 2921, Hungary
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Mosonmagyaróvár, 9200, Hungary
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Orosháza, 5900, Hungary
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Pécs, 7624, Hungary
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Siófok, 8600, Hungary
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Siófok, 8601, Hungary
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Sopron, 9400, Hungary
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Szentes, 6600, Hungary
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Zalaegerszeg, 8900, Hungary
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Hyderabad, Andhra Pradesh, 500004, India
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Visakhapatnam, Andhra Pradesh, 530003, India
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Visakhapatnam, Andhrapradesh, 530002, India
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Ahmedabad, Gujarat, 380060, India
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Vadodara, Gujarat, 390007, India
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Bangalore, Karnataka, 5600034, India
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Bangalore, Karnataka, 560054, India
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Bangalore, Karnataka, 560094, India
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Mysore, Karnataka, 570004, India
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Calicut, Kerala, 673 004, India
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Pune, Maharashta, 411011, India
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Nagpur, Maharashtra, 440010, India
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Nagpur, Maharashtra, 440012, India
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Pune, Maharashtra, 411001, India
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Pune, Maharashtra, 421006, India
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Jalandhar, Punjab, 144008, India
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Bikaner, Rajasthan, 334001, India
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Bikaner, Rajasthan, 334003, India
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Lucknow, Uttar Pradesh, 226003, India
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Ahmedabad, 380014, India
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Annāmalainagar, 608002, India
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Bangalore, 560052, India
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Chennai, 600006, India
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Hyderabad, 500001, India
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Hyderabad, 500044, India
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Indore, 452001, India
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Indore, 452014, India
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Kolkata, 700054, India
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Kottayam, 686016, India
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Lucknow, 226003, India
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Mumbai Naka, 422005, India
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Nashik, 422002, India
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New Delhi, 110025, India
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New Delhi, 110060, India
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New Delhi, 116025, India
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Pune, 411001, India
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Pune, 411004, India
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Thrissur, 680002, India
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Vijayawada, 520008, India
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Afula, 18101, Israel
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Ashkelon, 78306, Israel
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Giv‘atayim, 53583, Israel
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Hadera, 38100, Israel
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Haifa, 31096, Israel
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Haifa, 34362, Israel
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Holon, 58100, Israel
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Jerusalem, 91120, Israel
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Jerusalem, 91240, Israel
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Kfar Saba, 44281, Israel
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Nazareth, 16000, Israel
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Nazareth, 16100, Israel
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Petah Tikva, 49100, Israel
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Safed, 13100, Israel
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Tel Aviv, 64239, Israel
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Lido di Camaiore, Lucca, 55043, Italy
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Ascoli Piceno, 63100, Italy
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Campobasso, 86100, Italy
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Chieti, 66013, Italy
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Cremona, 26100, Italy
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Fidenza (Pr), 43036, Italy
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Genova, 16132, Italy
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Isernia, 86170, Italy
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Livorno, 57100, Italy
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Milan, 20132, Italy
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Napoli, 80131, Italy
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Palermo, 90127, Italy
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Reggio Emilia, 42100, Italy
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Roma, 00168, Italy
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San Daniele de Friuli, 33038, Italy
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Torino, 10153, Italy
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Vittorio Veneto (Tv), 31029, Italy
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Itoshima, Fukuoka, 819-1104, Japan
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Kurume, Fukuoka, 8390863, Japan
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Ohkawa-City, Fukuoka, 8310016, Japan
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Shirakawa, Fukushima, 961-0005, Japan
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Takasaki, Gunma, 3700829, Japan
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Asahikawa-Shi, Hokkaido, 0788214, Japan
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Katou-Gun, Hokkaido, 0800111, Japan
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Katou-gun, Hokkaido, 080111, Japan
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Sapporo, Hokkaido, 0028043, Japan
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Tomakomai-Shi, Hokkaido, 002-8043, Japan
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Tomakomai-shi, Hokkaido, 0028043, Japan
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Yūbari, Hokkaido, 0680402, Japan
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Kobe, Hyōgo, 6540026, Japan
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Izumi, Kagoshima-ken, 8990131, Japan
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Isehara, Kanagawa, 2591193, Japan
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Yokohama, Kanagawa, 2278501, Japan
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Yokohama, Kanagawa, 2458575, Japan
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Yokosuka, Kanagawa, 2388567, Japan
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Sendai, Miyagi, 983-8520, Japan
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Nara, Nara, 630-8305, Japan
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Izumi, Osaka, 594-0071, Japan
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Osaka, Osaka, 5330022, Japan
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Osaka, Osaka, 540-0006, Japan
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Osaka, Osaka, 5400006, Japan
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Suita, Osaka, 5658565, Japan
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Takatsuki, Osaka, 5690852, Japan
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Yao, Osaka, 5810036, Japan
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Saga, Saga-ken, 840-8571, Japan
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Saga, Saga-ken, 849-8501, Japan
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Kasukabe-Shi, Saitama, 344-0035, Japan
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Kasukabe-shi, Saitama, 3440035, Japan
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Itabashi-Ku, Tokyo, 173-0015, Japan
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Itabashi-ku, Tokyo, 1730015, Japan
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Vinereanu D, Wojdyla DM, Alexander JH, Lopes RD, Al-Khatib SM, Gersh BJ, Bahit MC, Hohnloser SH, Flaker GC, Rosenquist M, Hijazi Z, Wallentin L, Granger CB. Heart rate and death and hospitalization for heart failure in patients with persistent or permanent atrial fibrillation: Insights from the ARISTOTLE trial. Am Heart J. 2023 Nov;265:132-136. doi: 10.1016/j.ahj.2023.07.006. Epub 2023 Jul 26.
PMID: 37506747DERIVEDHijazi Z, Lindback J, Oldgren J, Benz AP, Alexander JH, Connolly SJ, Eikelboom JW, Granger CB, Lopes RD, Siegbahn A, Wallentin L. Individual net clinical outcome with oral anticoagulation in atrial fibrillation using the ABC-AF risk scores. Am Heart J. 2023 Jul;261:55-63. doi: 10.1016/j.ahj.2023.03.012. Epub 2023 Mar 27.
PMID: 36990261DERIVEDJamieson MJ, Byon W, Dettloff RW, Crawford M, Gargalovic PS, Merali SJ, Onorato J, Quintero AJ, Russ C. Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data. Am J Cardiovasc Drugs. 2022 Nov;22(6):615-631. doi: 10.1007/s40256-022-00524-x. Epub 2022 May 16.
PMID: 35570249DERIVEDPol T, Hijazi Z, Lindback J, Oldgren J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Siegbahn A, Wallentin L. Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation. Cardiovasc Res. 2022 Jul 20;118(9):2112-2123. doi: 10.1093/cvr/cvab262.
PMID: 34358298DERIVEDPol T, Hijazi Z, Lindback J, Alexander JH, Bahit MC, De Caterina R, Eikelboom JW, Ezekowitz MD, Gersh BJ, Granger CB, Hylek EM, Lopes R, Siegbahn A, Wallentin L. Evaluation of the prognostic value of GDF-15, ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas. Open Heart. 2021 Mar;8(1):e001471. doi: 10.1136/openhrt-2020-001471.
PMID: 33741689DERIVEDHijazi Z, Wallentin L, Lindback J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Pol T, Yusuf S, Oldgren J, Siegbahn A. Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation. J Am Heart Assoc. 2020 Dec 15;9(24):e018984. doi: 10.1161/JAHA.120.018984. Epub 2020 Dec 9.
PMID: 33292046DERIVEDWallentin L, Lindback J, Eriksson N, Hijazi Z, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Oldgren J, Siegbahn A. Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. Eur Heart J. 2020 Nov 1;41(41):4037-4046. doi: 10.1093/eurheartj/ehaa697.
PMID: 32984892DERIVEDHijazi Z, Granger CB, Hohnloser SH, Westerbergh J, Lindback J, Alexander JH, Keltai M, Parkhomenko A, Lopez-Sendon JL, Lopes RD, Siegbahn A, Wallentin L. Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation. J Am Heart Assoc. 2020 Sep 15;9(18):e017155. doi: 10.1161/JAHA.120.017155. Epub 2020 Aug 31.
PMID: 32865097DERIVEDZeitouni M, Giczewska A, Alexander JH. Reply: Specifics of Dose Modification in ARISTOTLE. J Am Coll Cardiol. 2020 Jul 7;76(1):128-129. doi: 10.1016/j.jacc.2020.05.013. No abstract available.
PMID: 32616154DERIVEDRosjo H, Hijazi Z, Omland T, Westerbergh J, Lyngbakken MN, Alexander JH, Gersh BJ, Granger CB, Hylek EM, Lopes RD, Siegbahn A, Wallentin L. Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial. J Intern Med. 2020 Aug;288(2):248-259. doi: 10.1111/joim.13072. Epub 2020 May 18.
PMID: 32350915DERIVEDZeitouni M, Giczewska A, Lopes RD, Wojdyla DM, Christersson C, Siegbahn A, De Caterina R, Steg PG, Granger CB, Wallentin L, Alexander JH; ARISTOTLE Investigators. Clinical and Pharmacological Effects of Apixaban Dose Adjustment in the ARISTOTLE Trial. J Am Coll Cardiol. 2020 Mar 17;75(10):1145-1155. doi: 10.1016/j.jacc.2019.12.060.
PMID: 32164888DERIVEDStanifer JW, Pokorney SD, Chertow GM, Hohnloser SH, Wojdyla DM, Garonzik S, Byon W, Hijazi Z, Lopes RD, Alexander JH, Wallentin L, Granger CB. Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease. Circulation. 2020 Apr 28;141(17):1384-1392. doi: 10.1161/CIRCULATIONAHA.119.044059. Epub 2020 Mar 12.
PMID: 32160801DERIVEDGarcia DA, Fisher DA, Mulder H, Wruck L, De Caterina R, Halvorsen S, Granger CB, Held C, Wallentin L, Alexander JH, Lopes RD. Gastrointestinal bleeding in patients with atrial fibrillation treated with Apixaban or warfarin: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial. Am Heart J. 2020 Mar;221:1-8. doi: 10.1016/j.ahj.2019.10.013. Epub 2019 Oct 31.
PMID: 31896036DERIVEDDalgaard F, Mulder H, Wojdyla DM, Lopes RD, Held C, Alexander JH, De Caterina R, Washam JB, Hylek EM, Garcia DA, Gersh BJ, Wallentin L, Granger CB, Al-Khatib SM. Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial. Circulation. 2020 Jan 7;141(1):10-20. doi: 10.1161/CIRCULATIONAHA.119.041296. Epub 2019 Nov 21.
PMID: 31747786DERIVEDGoldstein SA, Green J, Huber K, Wojdyla DM, Lopes RD, Alexander JH, Vinereanu D, Wallentin L, Granger CB, Al-Khatib SM. Characteristics and Outcomes of Atrial Fibrillation in Patients With Thyroid Disease (from the ARISTOTLE Trial). Am J Cardiol. 2019 Nov 1;124(9):1406-1412. doi: 10.1016/j.amjcard.2019.07.046. Epub 2019 Aug 7.
PMID: 31474328DERIVEDGuimaraes PO, Pokorney SD, Lopes RD, Wojdyla DM, Gersh BJ, Giczewska A, Carnicelli A, Lewis BS, Hanna M, Wallentin L, Vinereanu D, Alexander JH, Granger CB. Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: Insights from the ARISTOTLE trial. Clin Cardiol. 2019 May;42(5):568-571. doi: 10.1002/clc.23178. Epub 2019 Apr 9.
PMID: 30907005DERIVEDWasham JB, Hohnloser SH, Lopes RD, Wojdyla DM, Vinereanu D, Alexander JH, Gersh BJ, Hanna M, Horowitz J, Hylek EM, Xavier D, Verheugt FWA, Wallentin L, Granger CB; ARISTOTLE Committees and Investigators. Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial. J Thromb Thrombolysis. 2019 Apr;47(3):345-352. doi: 10.1007/s11239-019-01823-y.
PMID: 30790160DERIVEDHohnloser SH, Fudim M, Alexander JH, Wojdyla DM, Ezekowitz JA, Hanna M, Atar D, Hijazi Z, Bahit MC, Al-Khatib SM, Lopez-Sendon JL, Wallentin L, Granger CB, Lopes RD. Efficacy and Safety of Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Extremes in Body Weight. Circulation. 2019 May 14;139(20):2292-2300. doi: 10.1161/CIRCULATIONAHA.118.037955.
PMID: 30773022DERIVEDAlexander KP, Brouwer MA, Mulder H, Vinereanu D, Lopes RD, Proietti M, Al-Khatib SM, Hijazi Z, Halvorsen S, Hylek EM, Verheugt FWA, Alexander JH, Wallentin L, Granger CB; ARISTOTLE Investigators. Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial. Am Heart J. 2019 Feb;208:123-131. doi: 10.1016/j.ahj.2018.09.017. Epub 2018 Nov 22.
PMID: 30579505DERIVEDSandhu RK, Ezekowitz JA, Hijazi Z, Westerbergh J, Aulin J, Alexander JH, Granger CB, Halvorsen S, Hanna MS, Lopes RD, Siegbahn A, Wallentin L. Obesity paradox on outcome in atrial fibrillation maintained even considering the prognostic influence of biomarkers: insights from the ARISTOTLE trial. Open Heart. 2018 Nov 1;5(2):e000908. doi: 10.1136/openhrt-2018-000908. eCollection 2018.
PMID: 30487982DERIVEDChristersson C, Wallentin L, Andersson U, Alexander JH, Alings M, De Caterina R, Gersh BJ, Granger CB, Halvorsen S, Hanna M, Huber K, Hylek EM, Lopes RD, Oh BH, Siegbahn A. Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation. Heart. 2019 Feb;105(3):235-242. doi: 10.1136/heartjnl-2018-313351. Epub 2018 Sep 12.
PMID: 30209126DERIVEDHorowitz JD, De Caterina R, Heresztyn T, Alexander JH, Andersson U, Lopes RD, Steg PG, Hylek EM, Mohan P, Hanna M, Jansky P, Granger CB, Wallentin L; ARISTOTLE Investigators. Asymmetric and Symmetric Dimethylarginine Predict Outcomes in Patients With Atrial Fibrillation: An ARISTOTLE Substudy. J Am Coll Cardiol. 2018 Aug 14;72(7):721-733. doi: 10.1016/j.jacc.2018.05.058.
PMID: 30092948DERIVEDSharma A, Hijazi Z, Andersson U, Al-Khatib SM, Lopes RD, Alexander JH, Held C, Hylek EM, Leonardi S, Hanna M, Ezekowitz JA, Siegbahn A, Granger CB, Wallentin L. Use of Biomarkers to Predict Specific Causes of Death in Patients With Atrial Fibrillation. Circulation. 2018 Oct 16;138(16):1666-1676. doi: 10.1161/CIRCULATIONAHA.118.034125.
PMID: 29871978DERIVEDKopin D, Jones WS, Sherwood MW, Wojdyla DM, Wallentin L, Lewis BS, Verheugt FWA, Vinereanu D, Bahit MC, Halvorsen S, Huber K, Parkhomenko A, Granger CB, Lopes RD, Alexander JH. Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial. Am Heart J. 2018 Mar;197:133-141. doi: 10.1016/j.ahj.2017.11.005. Epub 2017 Nov 10.
PMID: 29447773DERIVEDPol T, Held C, Westerbergh J, Lindback J, Alexander JH, Alings M, Erol C, Goto S, Halvorsen S, Huber K, Hanna M, Lopes RD, Ruzyllo W, Granger CB, Hijazi Z. Dyslipidemia and Risk of Cardiovascular Events in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Therapy: Insights From the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) Trial. J Am Heart Assoc. 2018 Feb 1;7(3):e007444. doi: 10.1161/JAHA.117.007444.
PMID: 29419390DERIVEDGoto S, Merrill P, Wallentin L, Wojdyla DM, Hanna M, Avezum A, Easton JD, Harjola VP, Huber K, Lewis BS, Parkhomenko A, Zhu J, Granger CB, Lopes RD, Alexander JH. Antithrombotic therapy use and clinical outcomes following thrombo-embolic events in patients with atrial fibrillation: insights from ARISTOTLE. Eur Heart J Cardiovasc Pharmacother. 2018 Apr 1;4(2):75-81. doi: 10.1093/ehjcvp/pvy002.
PMID: 29385429DERIVEDVinereanu D, Wang A, Mulder H, Lopes RD, Jansky P, Lewis BS, Gersh BJ, Avezum A, Hanna M, Held C, Wallentin L, Granger CB, Alexander JH. Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease. Heart. 2018 Aug;104(15):1292-1299. doi: 10.1136/heartjnl-2017-312272. Epub 2018 Jan 19.
PMID: 29352007DERIVEDRao MP, Vinereanu D, Wojdyla DM, Alexander JH, Atar D, Hylek EM, Hanna M, Wallentin L, Lopes RD, Gersh BJ, Granger CB; Apixaban for Reduction in Stroke Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators. Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial. Am J Med. 2018 Mar;131(3):269-275.e2. doi: 10.1016/j.amjmed.2017.10.036. Epub 2017 Nov 6.
PMID: 29122636DERIVEDVinereanu D, Lopes RD, Mulder H, Gersh BJ, Hanna M, de Barros E Silva PGM, Atar D, Wallentin L, Granger CB, Alexander JH; ARISTOTLE Investigators. Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin. Stroke. 2017 Dec;48(12):3266-3273. doi: 10.1161/STROKEAHA.117.017574. Epub 2017 Oct 31.
PMID: 29089455DERIVEDHijazi Z, Oldgren J, Lindback J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Held C, Hylek EM, Lopes RD, Yusuf S, Granger CB, Siegbahn A, Wallentin L; ARISTOTLE and RE-LY Investigators. A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score. Eur Heart J. 2018 Feb 7;39(6):477-485. doi: 10.1093/eurheartj/ehx584.
PMID: 29069359DERIVEDHijazi Z, Lindahl B, Oldgren J, Andersson U, Lindback J, Granger CB, Alexander JH, Gersh BJ, Hanna M, Harjola VP, Hylek EM, Lopes RD, Siegbahn A, Wallentin L. Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time. J Am Heart Assoc. 2017 Jun 23;6(6):e004851. doi: 10.1161/JAHA.116.004851.
PMID: 28645934DERIVEDLopes RD, Guimaraes PO, Kolls BJ, Wojdyla DM, Bushnell CD, Hanna M, Easton JD, Thomas L, Wallentin L, Al-Khatib SM, Held C, Gabriel Melo de Barros E Silva P, Alexander JH, Granger CB, Diener HC. Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy. Blood. 2017 Jun 1;129(22):2980-2987. doi: 10.1182/blood-2016-08-731638. Epub 2017 Mar 29.
PMID: 28356246DERIVEDCowper PA, Sheng S, Lopes RD, Anstrom KJ, Stafford JA, Davidson-Ray L, Al-Khatib SM, Ansell J, Dorian P, Husted S, McMurray JJV, Steg PG, Alexander JH, Wallentin L, Granger CB, Mark DB. Economic Analysis of Apixaban Therapy for Patients With Atrial Fibrillation From a US Perspective: Results From the ARISTOTLE Randomized Clinical Trial. JAMA Cardiol. 2017 May 1;2(5):525-534. doi: 10.1001/jamacardio.2017.0065.
PMID: 28355434DERIVEDHu PT, Lopes RD, Stevens SR, Wallentin L, Thomas L, Alexander JH, Hanna M, Lewis BS, Verheugt FW, Granger CB, Jones WS. Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial. J Am Heart Assoc. 2017 Jan 17;6(1):e004699. doi: 10.1161/JAHA.116.004699.
PMID: 28096100DERIVEDBahit MC, Lopes RD, Wojdyla DM, Held C, Hanna M, Vinereanu D, Hylek EM, Verheugt F, Goto S, Alexander JH, Wallentin L, Granger CB. Non-major bleeding with apixaban versus warfarin in patients with atrial fibrillation. Heart. 2017 Apr;103(8):623-628. doi: 10.1136/heartjnl-2016-309901. Epub 2016 Oct 24.
PMID: 27798052DERIVEDOldgren J, Hijazi Z, Lindback J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Hylek EM, Lopes RD, Siegbahn A, Yusuf S, Wallentin L; RE-LY and ARISTOTLE Investigators. Performance and Validation of a Novel Biomarker-Based Stroke Risk Score for Atrial Fibrillation. Circulation. 2016 Nov 29;134(22):1697-1707. doi: 10.1161/CIRCULATIONAHA.116.022802. Epub 2016 Aug 28.
PMID: 27569438DERIVEDAlexander JH, Andersson U, Lopes RD, Hijazi Z, Hohnloser SH, Ezekowitz JA, Halvorsen S, Hanna M, Commerford P, Ruzyllo W, Huber K, Al-Khatib SM, Granger CB, Wallentin L; Apixaban for Reduction of Stroke and Other Thromboembolic Complications in Atrial Fibrillation (ARISTOTLE) Investigators. Apixaban 5 mg Twice Daily and Clinical Outcomes in Patients With Atrial Fibrillation and Advanced Age, Low Body Weight, or High Creatinine: A Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2016 Sep 1;1(6):673-81. doi: 10.1001/jamacardio.2016.1829.
PMID: 27463942DERIVEDHijazi Z, Hohnloser SH, Andersson U, Alexander JH, Hanna M, Keltai M, Parkhomenko A, Lopez-Sendon JL, Lopes RD, Siegbahn A, Granger CB, Wallentin L. Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation in Relation to Renal Function Over Time: Insights From the ARISTOTLE Randomized Clinical Trial. JAMA Cardiol. 2016 Jul 1;1(4):451-60. doi: 10.1001/jamacardio.2016.1170.
PMID: 27438322DERIVEDJaspers Focks J, Brouwer MA, Wojdyla DM, Thomas L, Lopes RD, Washam JB, Lanas F, Xavier D, Husted S, Wallentin L, Alexander JH, Granger CB, Verheugt FW. Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial. BMJ. 2016 Jun 15;353:i2868. doi: 10.1136/bmj.i2868.
PMID: 27306620DERIVEDHijazi Z, Oldgren J, Lindback J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Held C, Hylek EM, Lopes RD, Siegbahn A, Yusuf S, Granger CB, Wallentin L; ARISTOTLE and RE-LY Investigators. The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: a derivation and validation study. Lancet. 2016 Jun 4;387(10035):2302-2311. doi: 10.1016/S0140-6736(16)00741-8. Epub 2016 Apr 4.
PMID: 27056738DERIVEDHijazi Z, Lindback J, Alexander JH, Hanna M, Held C, Hylek EM, Lopes RD, Oldgren J, Siegbahn A, Stewart RA, White HD, Granger CB, Wallentin L; ARISTOTLE and STABILITY Investigators. The ABC (age, biomarkers, clinical history) stroke risk score: a biomarker-based risk score for predicting stroke in atrial fibrillation. Eur Heart J. 2016 May 21;37(20):1582-90. doi: 10.1093/eurheartj/ehw054. Epub 2016 Feb 25.
PMID: 26920728DERIVEDHijazi Z, Aulin J, Andersson U, Alexander JH, Gersh B, Granger CB, Hanna M, Horowitz J, Hylek EM, Lopes RD, Siegbahn A, Wallentin L; ARISTOTLE Investigators. Biomarkers of inflammation and risk of cardiovascular events in anticoagulated patients with atrial fibrillation. Heart. 2016 Apr;102(7):508-17. doi: 10.1136/heartjnl-2015-308887. Epub 2016 Feb 2.
PMID: 26839066DERIVEDRao MP, Halvorsen S, Wojdyla D, Thomas L, Alexander JH, Hylek EM, Hanna M, Bahit MC, Lopes RD, De Caterina R, Erol C, Goto S, Lanas F, Lewis BS, Husted S, Gersh BJ, Wallentin L, Granger CB; Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Steering Committee and Investigators. Blood Pressure Control and Risk of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: Results From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial. J Am Heart Assoc. 2015 Dec 1;4(12):e002015. doi: 10.1161/JAHA.115.002015.
PMID: 26627878DERIVEDVinereanu D, Stevens SR, Alexander JH, Al-Khatib SM, Avezum A, Bahit MC, Granger CB, Lopes RD, Halvorsen S, Hanna M, Husted S, Hylek EM, Margulescu AD, Wallentin L, Atar D. Clinical outcomes in patients with atrial fibrillation according to sex during anticoagulation with apixaban or warfarin: a secondary analysis of a randomized controlled trial. Eur Heart J. 2015 Dec 7;36(46):3268-75. doi: 10.1093/eurheartj/ehv447. Epub 2015 Sep 14.
PMID: 26371113DERIVEDAvezum A, Lopes RD, Schulte PJ, Lanas F, Gersh BJ, Hanna M, Pais P, Erol C, Diaz R, Bahit MC, Bartunek J, De Caterina R, Goto S, Ruzyllo W, Zhu J, Granger CB, Alexander JH. Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Findings From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial. Circulation. 2015 Aug 25;132(8):624-32. doi: 10.1161/CIRCULATIONAHA.114.014807. Epub 2015 Jun 23.
PMID: 26106009DERIVEDHeld C, Hylek EM, Alexander JH, Hanna M, Lopes RD, Wojdyla DM, Thomas L, Al-Khalidi H, Alings M, Xavier D, Ansell J, Goto S, Ruzyllo W, Rosenqvist M, Verheugt FW, Zhu J, Granger CB, Wallentin L. Clinical outcomes and management associated with major bleeding in patients with atrial fibrillation treated with apixaban or warfarin: insights from the ARISTOTLE trial. Eur Heart J. 2015 May 21;36(20):1264-72. doi: 10.1093/eurheartj/ehu463. Epub 2014 Dec 12.
PMID: 25499871DERIVEDHijazi Z, Siegbahn A, Andersson U, Lindahl B, Granger CB, Alexander JH, Atar D, Gersh BJ, Hanna M, Harjola VP, Horowitz J, Husted S, Hylek EM, Lopes RD, McMurray JJ, Wallentin L. Comparison of cardiac troponins I and T measured with high-sensitivity methods for evaluation of prognosis in atrial fibrillation: an ARISTOTLE substudy. Clin Chem. 2015 Feb;61(2):368-78. doi: 10.1373/clinchem.2014.226936. Epub 2014 Dec 1.
PMID: 25451868DERIVEDGarcia D, Alexander JH, Wallentin L, Wojdyla DM, Thomas L, Hanna M, Al-Khatib SM, Dorian P, Ansell J, Commerford P, Flaker G, Lanas F, Vinereanu D, Xavier D, Hylek EM, Held C, Verheugt FW, Granger CB, Lopes RD. Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures. Blood. 2014 Dec 11;124(25):3692-8. doi: 10.1182/blood-2014-08-595496. Epub 2014 Oct 15.
PMID: 25320240DERIVEDWallentin L, Hijazi Z, Andersson U, Alexander JH, De Caterina R, Hanna M, Horowitz JD, Hylek EM, Lopes RD, Asberg S, Granger CB, Siegbahn A; ARISTOTLE Investigators. Growth differentiation factor 15, a marker of oxidative stress and inflammation, for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial. Circulation. 2014 Nov 18;130(21):1847-58. doi: 10.1161/CIRCULATIONAHA.114.011204. Epub 2014 Oct 7.
PMID: 25294786DERIVEDHijazi Z, Siegbahn A, Andersson U, Granger CB, Alexander JH, Atar D, Gersh BJ, Mohan P, Harjola VP, Horowitz J, Husted S, Hylek EM, Lopes RD, McMurray JJ, Wallentin L; ARISTOTLE Investigators. High-sensitivity troponin I for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial. Circulation. 2014 Feb 11;129(6):625-34. doi: 10.1161/CIRCULATIONAHA.113.006286. Epub 2013 Nov 13.
PMID: 24226808DERIVEDFlaker G, Lopes RD, Al-Khatib SM, Hermosillo AG, Hohnloser SH, Tinga B, Zhu J, Mohan P, Garcia D, Bartunek J, Vinereanu D, Husted S, Harjola VP, Rosenqvist M, Alexander JH, Granger CB; ARISTOTLE Committees and Investigators. Efficacy and safety of apixaban in patients after cardioversion for atrial fibrillation: insights from the ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation). J Am Coll Cardiol. 2014 Mar 25;63(11):1082-7. doi: 10.1016/j.jacc.2013.09.062. Epub 2013 Nov 6.
PMID: 24211508DERIVEDHijazi Z, Wallentin L, Siegbahn A, Andersson U, Alexander JH, Atar D, Gersh BJ, Hanna M, Harjola VP, Horowitz JD, Husted S, Hylek EM, Lopes RD, McMurray JJ, Granger CB; ARISTOTLE Investigators. High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin. J Am Coll Cardiol. 2014 Jan 7-14;63(1):52-61. doi: 10.1016/j.jacc.2013.07.093. Epub 2013 Sep 19.
PMID: 24055845DERIVEDAlexander JH, Levy E, Lawrence J, Hanna M, Waclawski AP, Wang J, Califf RM, Wallentin L, Granger CB. Documentation of study medication dispensing in a prospective large randomized clinical trial: experiences from the ARISTOTLE Trial. Am Heart J. 2013 Sep;166(3):559-65. doi: 10.1016/j.ahj.2013.05.025. Epub 2013 Aug 15.
PMID: 24016507DERIVEDGarcia DA, Wallentin L, Lopes RD, Thomas L, Alexander JH, Hylek EM, Ansell J, Hanna M, Lanas F, Flaker G, Commerford P, Xavier D, Vinereanu D, Yang H, Granger CB. Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial. Am Heart J. 2013 Sep;166(3):549-58. doi: 10.1016/j.ahj.2013.05.016. Epub 2013 Jul 25.
PMID: 24016506DERIVEDWallentin L, Lopes RD, Hanna M, Thomas L, Hellkamp A, Nepal S, Hylek EM, Al-Khatib SM, Alexander JH, Alings M, Amerena J, Ansell J, Aylward P, Bartunek J, Commerford P, De Caterina R, Erol C, Harjola VP, Held C, Horowitz JD, Huber K, Husted S, Keltai M, Lanas F, Lisheng L, McMurray JJ, Oh BH, Rosenqvist M, Ruzyllo W, Steg PG, Vinereanu D, Xavier D, Granger CB; Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators. Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation. Circulation. 2013 Jun 4;127(22):2166-76. doi: 10.1161/CIRCULATIONAHA.112.142158. Epub 2013 May 2.
PMID: 23640971DERIVEDMcMurray JJ, Ezekowitz JA, Lewis BS, Gersh BJ, van Diepen S, Amerena J, Bartunek J, Commerford P, Oh BH, Harjola VP, Al-Khatib SM, Hanna M, Alexander JH, Lopes RD, Wojdyla DM, Wallentin L, Granger CB; ARISTOTLE Committees and Investigators. Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial. Circ Heart Fail. 2013 May;6(3):451-60. doi: 10.1161/CIRCHEARTFAILURE.112.000143. Epub 2013 Apr 10.
PMID: 23575255DERIVEDHijazi Z, Wallentin L, Siegbahn A, Andersson U, Christersson C, Ezekowitz J, Gersh BJ, Hanna M, Hohnloser S, Horowitz J, Huber K, Hylek EM, Lopes RD, McMurray JJ, Granger CB. N-terminal pro-B-type natriuretic peptide for risk assessment in patients with atrial fibrillation: insights from the ARISTOTLE Trial (Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation). J Am Coll Cardiol. 2013 Jun 4;61(22):2274-84. doi: 10.1016/j.jacc.2012.11.082. Epub 2013 Apr 3.
PMID: 23563134DERIVEDLopes RD, Al-Khatib SM, Wallentin L, Yang H, Ansell J, Bahit MC, De Caterina R, Dorian P, Easton JD, Erol C, Ezekowitz JA, Gersh BJ, Granger CB, Hohnloser SH, Horowitz J, Hylek EM, McMurray JJ, Mohan P, Vinereanu D, Alexander JH. Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial. Lancet. 2012 Nov 17;380(9855):1749-58. doi: 10.1016/S0140-6736(12)60986-6. Epub 2012 Oct 2.
PMID: 23036896DERIVEDEaston JD, Lopes RD, Bahit MC, Wojdyla DM, Granger CB, Wallentin L, Alings M, Goto S, Lewis BS, Rosenqvist M, Hanna M, Mohan P, Alexander JH, Diener HC; ARISTOTLE Committees and Investigators. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012 Jun;11(6):503-11. doi: 10.1016/S1474-4422(12)70092-3. Epub 2012 May 8.
PMID: 22572202DERIVEDGranger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L; ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011 Sep 15;365(11):981-92. doi: 10.1056/NEJMoa1107039. Epub 2011 Aug 27.
PMID: 21870978DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- BMS Study Director
- Organization
- Bristol-Myers Squibb
Study Officials
- STUDY DIRECTOR
Bristol-Myers Squibb
Bristol-Myers Squibb
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 18, 2006
First Posted
December 19, 2006
Study Start
December 31, 2006
Primary Completion
May 25, 2011
Study Completion
May 25, 2011
Last Updated
July 3, 2018
Results First Posted
April 29, 2013
Record last verified: 2018-05