An Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial Fibrillation
A Prospective, Randomized, Double-Blind, Parallel-Group, Multicenter, Non-inferiority Study Comparing the Efficacy and Safety of Rivaroxaban (BAY 59-7939) With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Subjects With Non-Valvular Atrial Fibrillation
4 other identifiers
interventional
14,269
43 countries
927
Brief Summary
The purpose of this study is to compare the efficacy and safety of rivaroxaban with warfarin for the prevention of blood clots in the brain (referred to as stroke) and blood clots in other parts of the body referred to as non-central nervous system systemic embolism) in patients with non-valvular atrial fibrillation (a heart rhythm disorder).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 atrial-fibrillation
Started Dec 2006
Typical duration for phase_3 atrial-fibrillation
927 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 23, 2006
CompletedFirst Posted
Study publicly available on registry
November 27, 2006
CompletedStudy Start
First participant enrolled
December 1, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2010
CompletedResults Posted
Study results publicly available
July 17, 2012
CompletedApril 29, 2014
April 1, 2014
3.8 years
November 23, 2006
December 2, 2011
April 10, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
The Composite Event of Stroke/Non-CNS Systemic Embolism: Primary Efficacy (Non-Inferiority)
The number of patients with the first occurrence of a stroke or non-CNS systemic embolism while on treatment (defined as the time interval from the first dose to the last dose of study drug plus 2 days). The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
Up to 4 years
The Composite of Event of Stroke/Non-CNS Systemic Embolism: Primary Efficacy (Superiority)
The number of patients with the first occurrence of a stroke or non-CNS systemic embolism while on treatment (defined as the time interval from the first dose to the last dose of study drug plus 2 days). The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
Up to 4 years
The Composite Event of Major/Non-major Clinically Relevant Bleeding Events: Primary Safety
The number of patients with the first occurrence of a major or non-major clinically relevant bleeding event while on treatment. The statistical analysis is based on time from the first dose of study drug to the first occurrence of the event while on treatment.
Up to 4 years
Secondary Outcomes (7)
The Composite Event of Stroke/Non-CNS Systemic Embolism/Vascular Death
Up to 4 years
The Composite Event of Stroke/Non-CNS Systemic Embolism/Myocardial Infarction/Vascular Death
Up to 4 years
The Individual Components of the Composite Primary and Major Secondary Efficacy Outcome Measures: Stroke
Up to 4 years
The Individual Components of the Composite Primary and Major Secondary Efficacy Outcome Measures: Non-CNS Systemic Embolism
Up to 4 years
The Individual Components of the Composite Primary and Major Secondary Efficacy Outcome Measures: Myocardial Infarction
Up to 4 years
- +2 more secondary outcomes
Study Arms (2)
Rivaroxaban
EXPERIMENTALWarfarin
ACTIVE COMPARATORInterventions
Type=exact number, unit=mg, number=20, form=tablet, route=oral use. One 20 mg tablet once daily for an expected maximum treatment period of up to 32 months that may extend up to 4 years (Patients with moderate renal impairment at screening willl have a dose adaptation to rivaroxaban 15 mg, orally, once daily for an expected maximum treatment period of up to 32 months that may extend up to 4 years)
Type=exact number, unit=mg, number=1, 2.5, or 5 mg, form=tablet, route=oral use. Number of warfarin tablets to be determined based on target INR values once daily for an expected maximum treatment period of up to 32 months that may extend up to 4 years
Form=tablet, route=oral. One warfarin placebo tablet taken orally once daily for up to an expected maximum treatment period of 32 months that may extend up to 4 years
Form-tablet, Route=oral administration. Number of rivaroxaban placebo determined by the number of warfarin tablets taken. Duration of treatment is up to an expected maximum treatment period of 32 months that may extend up to 4 years
Eligibility Criteria
You may qualify if:
- Patients must have documented atrial fibrillation on 2 separate occasions within 6 months before screening
- History of a prior stroke, transient ischemic attack or non-neurologic systemic embolism believed to be cardiac in origin, or at least two of the following risk factors: heart failure, hypertension, age 75 years or greater, diabetes mellitus
You may not qualify if:
- Significant mitral stenosis
- Transient atrial fibrillation caused by a reversible disorder
- Active internal bleeding
- Severe disabling stroke
- History of intracranial bleeding
- Hemorrhagic disorders
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (932)
Unknown Facility
Birmingham, Alabama, United States
Unknown Facility
Dothan, Alabama, United States
Unknown Facility
Geneva, Alabama, United States
Unknown Facility
Mobile, Alabama, United States
Unknown Facility
Pell City, Alabama, United States
Unknown Facility
Glendale, Arizona, United States
Unknown Facility
Phoenix, Arizona, United States
Unknown Facility
Scottsdale, Arizona, United States
Unknown Facility
Tucson, Arizona, United States
Unknown Facility
Fort Smith, Arkansas, United States
Unknown Facility
Little Rock, Arkansas, United States
Unknown Facility
Anaheim, California, United States
Unknown Facility
Bakersfield, California, United States
Unknown Facility
Carmichael, California, United States
Unknown Facility
Corona, California, United States
Unknown Facility
Fair Oaks, California, United States
Unknown Facility
Glendale, California, United States
Unknown Facility
Healdsburg, California, United States
Unknown Facility
Laguna Hills, California, United States
Unknown Facility
Long Beach, California, United States
Unknown Facility
Los Angeles, California, United States
Unknown Facility
Los Gatos, California, United States
Unknown Facility
Mission Viejo, California, United States
Unknown Facility
Modesto, California, United States
Unknown Facility
Mountain View, California, United States
Unknown Facility
Northridge, California, United States
Unknown Facility
Oakland, California, United States
Unknown Facility
Orange, California, United States
Unknown Facility
Pismo Beach, California, United States
Unknown Facility
Sacramento, California, United States
Unknown Facility
San Diego, California, United States
Unknown Facility
San Leandro, California, United States
Unknown Facility
Santa Clara, California, United States
Unknown Facility
Santa Monica, California, United States
Unknown Facility
Santa Rosa, California, United States
Unknown Facility
Sylmar, California, United States
Unknown Facility
Torrance, California, United States
Unknown Facility
Ventura, California, United States
Unknown Facility
Yuba City, California, United States
Unknown Facility
Boulder, Colorado, United States
Unknown Facility
Denver, Colorado, United States
Unknown Facility
Littleton, Colorado, United States
Unknown Facility
Pueblo, Colorado, United States
Unknown Facility
Danbury, Connecticut, United States
Unknown Facility
Guilford, Connecticut, United States
Unknown Facility
Newark, Delaware, United States
Unknown Facility
Bradenton, Florida, United States
Unknown Facility
Clearwater, Florida, United States
Unknown Facility
Daytona Beach, Florida, United States
Unknown Facility
DeBary, Florida, United States
Unknown Facility
Deerfield Beach, Florida, United States
Unknown Facility
Fort Lauderdale, Florida, United States
Unknown Facility
Fort Myers, Florida, United States
Unknown Facility
Fort Walton Beach, Florida, United States
Unknown Facility
Hialeah, Florida, United States
Unknown Facility
Hollywood, Florida, United States
Unknown Facility
Hudson, Florida, United States
Unknown Facility
Inverness, Florida, United States
Unknown Facility
Jacksonville, Florida, United States
Unknown Facility
Jupiter, Florida, United States
Unknown Facility
Kissimmee, Florida, United States
Unknown Facility
Largo, Florida, United States
Unknown Facility
Melbourne, Florida, United States
Unknown Facility
Miami, Florida, United States
Unknown Facility
Miami Beach, Florida, United States
Unknown Facility
Ocala, Florida, United States
Unknown Facility
Orange Park, Florida, United States
Unknown Facility
Orlando, Florida, United States
Unknown Facility
Ormond Beach, Florida, United States
Unknown Facility
Palm Beach Gardens, Florida, United States
Unknown Facility
Palm Harbor, Florida, United States
Unknown Facility
Port Charlotte, Florida, United States
Unknown Facility
Safety Harbor, Florida, United States
Unknown Facility
St. Petersburg, Florida, United States
Unknown Facility
Tallahassee, Florida, United States
Unknown Facility
Tamarac, Florida, United States
Unknown Facility
Tampa, Florida, United States
Unknown Facility
Albany, Georgia, United States
Unknown Facility
Atlanta, Georgia, United States
Unknown Facility
Augusta, Georgia, United States
Unknown Facility
Columbus, Georgia, United States
Unknown Facility
Savannah, Georgia, United States
Unknown Facility
Boise, Idaho, United States
Unknown Facility
Idaho Falls, Idaho, United States
Unknown Facility
Nampa, Idaho, United States
Unknown Facility
Aurora, Illinois, United States
Unknown Facility
Bannockburn, Illinois, United States
Unknown Facility
Chicago, Illinois, United States
Unknown Facility
Evergreen Park, Illinois, United States
Unknown Facility
Fulton, Illinois, United States
Unknown Facility
Lombard, Illinois, United States
Unknown Facility
Melrose Park, Illinois, United States
Unknown Facility
Moline, Illinois, United States
Unknown Facility
Park Ridge, Illinois, United States
Unknown Facility
Peoria, Illinois, United States
Unknown Facility
Quincy, Illinois, United States
Unknown Facility
Rock Island, Illinois, United States
Unknown Facility
Rockford, Illinois, United States
Unknown Facility
Springfield, Illinois, United States
Unknown Facility
Watseka, Illinois, United States
Unknown Facility
Anderson, Indiana, United States
Unknown Facility
Hammond, Indiana, United States
Unknown Facility
Indianapolis, Indiana, United States
Unknown Facility
Merrillville, Indiana, United States
Unknown Facility
Muncie, Indiana, United States
Unknown Facility
Munster, Indiana, United States
Unknown Facility
South Bend, Indiana, United States
Unknown Facility
Waterloo, Iowa, United States
Unknown Facility
Crestview Hills, Kentucky, United States
Unknown Facility
Edgewood, Kentucky, United States
Unknown Facility
Lexington, Kentucky, United States
Unknown Facility
Louisville, Kentucky, United States
Unknown Facility
Madisonville, Kentucky, United States
Unknown Facility
Mount Sterling, Kentucky, United States
Unknown Facility
Owensboro, Kentucky, United States
Unknown Facility
Houma, Louisiana, United States
Unknown Facility
Lake Charles, Louisiana, United States
Unknown Facility
New Orleans, Louisiana, United States
Unknown Facility
Thibodaux, Louisiana, United States
Unknown Facility
Vidalia, Louisiana, United States
Unknown Facility
Bangor, Maine, United States
Unknown Facility
Scarborough, Maine, United States
Unknown Facility
Annapolis, Maryland, United States
Unknown Facility
Beltsville, Maryland, United States
Unknown Facility
Columbia, Maryland, United States
Unknown Facility
Salisbury, Maryland, United States
Unknown Facility
Boston, Massachusetts, United States
Unknown Facility
Brighton, Massachusetts, United States
Unknown Facility
Framingham, Massachusetts, United States
Unknown Facility
Bay City, Michigan, United States
Unknown Facility
Bridgman, Michigan, United States
Unknown Facility
Chelsea, Michigan, United States
Unknown Facility
Dearborn, Michigan, United States
Unknown Facility
Detroit, Michigan, United States
Unknown Facility
Lansing, Michigan, United States
Unknown Facility
Mount Clemens, Michigan, United States
Unknown Facility
Petoskey, Michigan, United States
Unknown Facility
Traverse City, Michigan, United States
Unknown Facility
Troy, Michigan, United States
Unknown Facility
Minneapolis, Minnesota, United States
Unknown Facility
Saint Paul, Minnesota, United States
Unknown Facility
Picayune, Mississippi, United States
Unknown Facility
Tupelo, Mississippi, United States
Unknown Facility
Lexington, Missouri, United States
Unknown Facility
Springfield, Missouri, United States
Unknown Facility
St Louis, Missouri, United States
Unknown Facility
Anaconda, Montana, United States
Unknown Facility
Great Falls, Montana, United States
Unknown Facility
Beatrice, Nebraska, United States
Unknown Facility
Lincoln, Nebraska, United States
Unknown Facility
Omaha, Nebraska, United States
Unknown Facility
Las Vegas, Nevada, United States
Unknown Facility
Pahrump, Nevada, United States
Unknown Facility
Manchester, New Hampshire, United States
Unknown Facility
Bridgewater, New Jersey, United States
Unknown Facility
Elmer, New Jersey, United States
Unknown Facility
Haddon Heights, New Jersey, United States
Unknown Facility
New Brunswick, New Jersey, United States
Unknown Facility
Paterson, New Jersey, United States
Unknown Facility
Ridgewood, New Jersey, United States
Unknown Facility
Sewell, New Jersey, United States
Unknown Facility
Springfield, New Jersey, United States
Unknown Facility
Toms River, New Jersey, United States
Unknown Facility
Wayne, New Jersey, United States
Unknown Facility
Albuquerque, New Mexico, United States
Unknown Facility
Brooklyn, New York, United States
Unknown Facility
Buffalo, New York, United States
Unknown Facility
Cortlandt Manor, New York, United States
Unknown Facility
East Syracuse, New York, United States
Unknown Facility
New York, New York, United States
Unknown Facility
Northport, New York, United States
Unknown Facility
Saratoga Springs, New York, United States
Unknown Facility
Schenectady, New York, United States
Unknown Facility
Staten Island, New York, United States
Unknown Facility
Stony Brook, New York, United States
Unknown Facility
Syracuse, New York, United States
Unknown Facility
The Bronx, New York, United States
Unknown Facility
Williamsville, New York, United States
Unknown Facility
Asheville, North Carolina, United States
Unknown Facility
Durham, North Carolina, United States
Unknown Facility
Greensboro, North Carolina, United States
Unknown Facility
Hickory, North Carolina, United States
Unknown Facility
Jacksonville, North Carolina, United States
Unknown Facility
New Bern, North Carolina, United States
Unknown Facility
Raleigh, North Carolina, United States
Unknown Facility
Reidsville, North Carolina, United States
Unknown Facility
Rocky Mount, North Carolina, United States
Unknown Facility
Statesville, North Carolina, United States
Unknown Facility
Winston-Salem, North Carolina, United States
Unknown Facility
Fargo, North Dakota, United States
Unknown Facility
Minot, North Dakota, United States
Unknown Facility
Canton, Ohio, United States
Unknown Facility
Cincinnati, Ohio, United States
Unknown Facility
Columbus, Ohio, United States
Unknown Facility
Dayton, Ohio, United States
Unknown Facility
Fairfield, Ohio, United States
Unknown Facility
Mansfield, Ohio, United States
Unknown Facility
Massillon, Ohio, United States
Unknown Facility
Maumee, Ohio, United States
Unknown Facility
Toledo, Ohio, United States
Unknown Facility
Zanesville, Ohio, United States
Unknown Facility
Bartlesville, Oklahoma, United States
Unknown Facility
Midwest City, Oklahoma, United States
Unknown Facility
Norman, Oklahoma, United States
Unknown Facility
Oklahoma City, Oklahoma, United States
Unknown Facility
Yukon, Oklahoma, United States
Unknown Facility
Portland, Oregon, United States
Unknown Facility
Beaver, Pennsylvania, United States
Unknown Facility
Bethlehem, Pennsylvania, United States
Unknown Facility
Danville, Pennsylvania, United States
Unknown Facility
Doylestown, Pennsylvania, United States
Unknown Facility
Jeannette, Pennsylvania, United States
Unknown Facility
Jersey Shore, Pennsylvania, United States
Unknown Facility
Lansdale, Pennsylvania, United States
Unknown Facility
Leetsdale, Pennsylvania, United States
Unknown Facility
Lewistown, Pennsylvania, United States
Unknown Facility
Norristown, Pennsylvania, United States
Unknown Facility
North Wales, Pennsylvania, United States
Unknown Facility
Philadelphia, Pennsylvania, United States
Unknown Facility
Philipsburg, Pennsylvania, United States
Unknown Facility
Phoenixville, Pennsylvania, United States
Unknown Facility
Pittsburgh, Pennsylvania, United States
Unknown Facility
Sayre, Pennsylvania, United States
Unknown Facility
Scranton, Pennsylvania, United States
Unknown Facility
Shippensburg, Pennsylvania, United States
Unknown Facility
State College, Pennsylvania, United States
Unknown Facility
Topton, Pennsylvania, United States
Unknown Facility
Wilkes-Barre, Pennsylvania, United States
Unknown Facility
Wormleysburg, Pennsylvania, United States
Unknown Facility
Wyomissing, Pennsylvania, United States
Unknown Facility
Pawtucket, Rhode Island, United States
Unknown Facility
Westerly, Rhode Island, United States
Unknown Facility
Anderson, South Carolina, United States
Unknown Facility
Charleston, South Carolina, United States
Unknown Facility
Columbia, South Carolina, United States
Unknown Facility
Easley, South Carolina, United States
Unknown Facility
Sumter, South Carolina, United States
Unknown Facility
Rapid City, South Dakota, United States
Unknown Facility
Athens, Tennessee, United States
Unknown Facility
Bristol, Tennessee, United States
Unknown Facility
Chattanooga, Tennessee, United States
Unknown Facility
Harriman, Tennessee, United States
Unknown Facility
Jackson, Tennessee, United States
Unknown Facility
Johnson City, Tennessee, United States
Unknown Facility
Kingsport, Tennessee, United States
Unknown Facility
Knoxville, Tennessee, United States
Unknown Facility
Lexington, Tennessee, United States
Unknown Facility
Memphis, Tennessee, United States
Unknown Facility
Nashville, Tennessee, United States
Unknown Facility
Amarillo, Texas, United States
Unknown Facility
Beaumont, Texas, United States
Unknown Facility
Brownsville, Texas, United States
Unknown Facility
Corpus Christi, Texas, United States
Unknown Facility
Daingerfield, Texas, United States
Unknown Facility
Dallas, Texas, United States
Unknown Facility
DeSoto, Texas, United States
Unknown Facility
Fort Sam Houston, Texas, United States
Unknown Facility
Fort Worth, Texas, United States
Unknown Facility
Houston, Texas, United States
Unknown Facility
Humble, Texas, United States
Unknown Facility
Hurst, Texas, United States
Unknown Facility
Kerrville, Texas, United States
Unknown Facility
Kingwood, Texas, United States
Unknown Facility
Lubbock, Texas, United States
Unknown Facility
McAllen, Texas, United States
Unknown Facility
Odessa, Texas, United States
Unknown Facility
Plano, Texas, United States
Unknown Facility
San Antonio, Texas, United States
Unknown Facility
Sugar Land, Texas, United States
Unknown Facility
Tomball, Texas, United States
Unknown Facility
Victoria, Texas, United States
Unknown Facility
Murray, Utah, United States
Unknown Facility
Salt Lake City, Utah, United States
Unknown Facility
Burlington, Vermont, United States
Unknown Facility
Blacksburg, Virginia, United States
Unknown Facility
Chester, Virginia, United States
Unknown Facility
Danville, Virginia, United States
Unknown Facility
Fairfax, Virginia, United States
Unknown Facility
Fredericksburg, Virginia, United States
Unknown Facility
Lynchburg, Virginia, United States
Unknown Facility
Richmond, Virginia, United States
Unknown Facility
Roanoke, Virginia, United States
Unknown Facility
Virginia Beach, Virginia, United States
Unknown Facility
Williamsburg, Virginia, United States
Unknown Facility
Bellingham, Washington, United States
Unknown Facility
Port Orchard, Washington, United States
Unknown Facility
Seattle, Washington, United States
Unknown Facility
Spokane, Washington, United States
Unknown Facility
Tacoma, Washington, United States
Unknown Facility
Vancouver, Washington, United States
Unknown Facility
Burlington, Wisconsin, United States
Unknown Facility
Elkhorn, Wisconsin, United States
Unknown Facility
La Crosse, Wisconsin, United States
Unknown Facility
Milwaukee, Wisconsin, United States
Unknown Facility
Wausau, Wisconsin, United States
Unknown Facility
Bahía Blanca, Argentina
Unknown Facility
Buenos Aires, Argentina
Unknown Facility
Cipolletti, Argentina
Unknown Facility
Corrientes, Argentina
Unknown Facility
Córdoba, Argentina
Unknown Facility
La Plata, Argentina
Unknown Facility
Mar del Plata, Argentina
Unknown Facility
Quilmes, Argentina
Unknown Facility
Rosario, Argentina
Unknown Facility
Salta, Argentina
Unknown Facility
San Martín, Argentina
Unknown Facility
San Miguel de Tucumán, Argentina
Unknown Facility
Santa Fe, Argentina
Unknown Facility
Adelaide, Australia
Unknown Facility
Auchenflower, Australia
Unknown Facility
Bedford Park, Australia
Unknown Facility
Box Hill, Australia
Unknown Facility
Caboolture, Australia
Unknown Facility
Cairns, Australia
Unknown Facility
Camperdown, Australia
Unknown Facility
Chermside, Australia
Unknown Facility
Clayton, Australia
Unknown Facility
Coffs Harbour, Australia
Unknown Facility
Footscray, Australia
Unknown Facility
Garran, Australia
Unknown Facility
Geelong, Australia
Unknown Facility
Gosford, Australia
Unknown Facility
Heidelberg Heights, Australia
Unknown Facility
Herston, Australia
Unknown Facility
Hobart, Australia
Unknown Facility
Joondalup, Australia
Unknown Facility
Lismore, Australia
Unknown Facility
Liverpool, Australia
Unknown Facility
Miranda, Australia
Unknown Facility
Nedlands, Australia
Unknown Facility
New Lambton Heights, Australia
Unknown Facility
Parkville, Australia
Unknown Facility
Penrith, Australia
Unknown Facility
Prahran, Australia
Unknown Facility
Reservoir, Australia
Unknown Facility
Southport, Australia
Unknown Facility
Windsor, Australia
Unknown Facility
Wolloongabba, Australia
Unknown Facility
Feldkirch Vorarlberg Vorarlber, Austria
Unknown Facility
Graz, Austria
Unknown Facility
Tulln Niederosterreich Niedero, Austria
Unknown Facility
Vienna, Austria
Unknown Facility
Wien Wien, Austria
Unknown Facility
Antwerp, Belgium
Unknown Facility
Bonheiden, Belgium
Unknown Facility
Brasschaat, Belgium
Unknown Facility
Bruges, Belgium
Unknown Facility
Brussels, Belgium
Unknown Facility
Ghent, Belgium
Unknown Facility
Haine-Saint-Paul, Belgium
Unknown Facility
Leuven, Belgium
Unknown Facility
Mol, Belgium
Unknown Facility
Nivelles, Belgium
Unknown Facility
Ottignies, Belgium
Unknown Facility
Roeselare, Belgium
Unknown Facility
Seraing, Belgium
Unknown Facility
Tienen, Belgium
Unknown Facility
Belo Horizonte, Brazil
Unknown Facility
Blumenau, Brazil
Unknown Facility
Brasília, Brazil
Unknown Facility
Campina Grande do Sul, Brazil
Unknown Facility
Campinas, Brazil
Unknown Facility
Campo Grande, Brazil
Unknown Facility
Curitiba, Brazil
Unknown Facility
Fortaleza, Brazil
Unknown Facility
Goiânia, Brazil
Unknown Facility
Maceió, Brazil
Unknown Facility
Maringá, Brazil
Unknown Facility
Marília, Brazil
Unknown Facility
Porto Alegre, Brazil
Unknown Facility
Recife, Brazil
Unknown Facility
Rio de Janeiro, Brazil
Unknown Facility
Rio de Janeiro Br, Brazil
Unknown Facility
Salvador, Brazil
Unknown Facility
Santo André, Brazil
Unknown Facility
São Caetano do Sul, Brazil
Unknown Facility
São José do Rio Preto, Brazil
Unknown Facility
São Paulo, Brazil
Unknown Facility
Sorocaba, Brazil
Unknown Facility
Uberlândia, Brazil
Unknown Facility
Dimitrovgrad, Bulgaria
Unknown Facility
Pleven, Bulgaria
Unknown Facility
Plovdiv, Bulgaria
Unknown Facility
Russel, Bulgaria
Unknown Facility
Sofia, Bulgaria
Unknown Facility
Veliko Tarnovo, Bulgaria
Unknown Facility
Calgary, Alberta, Canada
Unknown Facility
Edmonton, Alberta, Canada
Unknown Facility
Abbotsford, British Columbia, Canada
Unknown Facility
Burnaby, British Columbia, Canada
Unknown Facility
Campbell River, British Columbia, Canada
Unknown Facility
Delta, British Columbia, Canada
Unknown Facility
Kelowna, British Columbia, Canada
Unknown Facility
Langley, British Columbia, Canada
Unknown Facility
New Westminster, British Columbia, Canada
Unknown Facility
Penticton, British Columbia, Canada
Unknown Facility
Vancouver, British Columbia, Canada
Unknown Facility
Victoria, British Columbia, Canada
Unknown Facility
West Vancouver, British Columbia, Canada
Unknown Facility
Winnipeg, Manitoba, Canada
Unknown Facility
Moncton, New Brunswick, Canada
Unknown Facility
Saint John, New Brunswick, Canada
Unknown Facility
St. John's, Newfoundland and Labrador, Canada
Unknown Facility
Halifax, Nova Scotia, Canada
Unknown Facility
Sydney, Nova Scotia, Canada
Unknown Facility
Ajax, Ontario, Canada
Unknown Facility
Beamsville, Ontario, Canada
Unknown Facility
Belleville, Ontario, Canada
Unknown Facility
Brampton, Ontario, Canada
Unknown Facility
Burlington, Ontario, Canada
Unknown Facility
Cambridge, Ontario, Canada
Unknown Facility
Corunna, Ontario, Canada
Unknown Facility
Courtice, Ontario, Canada
Unknown Facility
E. London, Ontario, Canada
Unknown Facility
Etobicoke, Ontario, Canada
Unknown Facility
Fort Erie, Ontario, Canada
Unknown Facility
Greater Sudbury, Ontario, Canada
Unknown Facility
Hamilton, Ontario, Canada
Unknown Facility
Kitchener, Ontario, Canada
Unknown Facility
Listowel, Ontario, Canada
Unknown Facility
London, Ontario, Canada
Unknown Facility
Markham, Ontario, Canada
Unknown Facility
Mississauga, Ontario, Canada
Unknown Facility
North Bay, Ontario, Canada
Unknown Facility
North York, Ontario, Canada
Unknown Facility
Oakville, Ontario, Canada
Unknown Facility
Oshawa, Ontario, Canada
Unknown Facility
Ottawa, Ontario, Canada
Unknown Facility
Parry Sound, Ontario, Canada
Unknown Facility
Richmond Hill, Ontario, Canada
Unknown Facility
Sarnia, Ontario, Canada
Unknown Facility
Sault Ste. Marie, Ontario, Canada
Unknown Facility
Scarborough Village, Ontario, Canada
Unknown Facility
Strathroy, Ontario, Canada
Unknown Facility
Thornhill, Ontario, Canada
Unknown Facility
Thunder Bay, Ontario, Canada
Unknown Facility
Toronto, Ontario, Canada
Unknown Facility
Waterloo, Ontario, Canada
Unknown Facility
Whitby, Ontario, Canada
Unknown Facility
York, Ontario, Canada
Unknown Facility
Chicoutimi, Quebec, Canada
Unknown Facility
Greenfield Park, Quebec, Canada
Unknown Facility
Joliette, Quebec, Canada
Unknown Facility
Jonquière, Quebec, Canada
Unknown Facility
Lachine, Quebec, Canada
Unknown Facility
Longueuil, Quebec, Canada
Unknown Facility
Mirabel, Quebec, Canada
Unknown Facility
Montreal, Quebec, Canada
Unknown Facility
Pointe-Claire, Quebec, Canada
Unknown Facility
Québec, Quebec, Canada
Unknown Facility
Saint-Jérôme, Quebec, Canada
Unknown Facility
Saint-Lambert, Quebec, Canada
Unknown Facility
Saint-Léonard, Quebec, Canada
Unknown Facility
Sherbrooke, Quebec, Canada
Unknown Facility
North Battleford, Saskatchewan, Canada
Unknown Facility
Saskatoon, Saskatchewan, Canada
Unknown Facility
Arica I Region, Chile
Unknown Facility
Chila, Chile
Unknown Facility
Concepción VIII, Chile
Unknown Facility
Osorno X Region, Chile
Unknown Facility
Osorno X Región, Chile
Unknown Facility
Rancagua VI Region, Chile
Unknown Facility
San Felipe V Region, Chile
Unknown Facility
Santiago de Chile Rm, Chile
Unknown Facility
Santiago Rm, Chile
Unknown Facility
Temuco IX, Chile
Unknown Facility
Valdivia X Región, Chile
Unknown Facility
Viña Del Mar V Región, Chile
Unknown Facility
Beijing, China
Unknown Facility
Changchun, China
Unknown Facility
Changsha, China
Unknown Facility
Changzhou, China
Unknown Facility
Chengdu, China
Unknown Facility
Chongqing, China
Unknown Facility
Dalian, China
Unknown Facility
Daqing, China
Unknown Facility
Guangzhou, China
Unknown Facility
Haikou, China
Unknown Facility
Hangzhou, China
Unknown Facility
Harbin, China
Unknown Facility
Jinan, China
Unknown Facility
Nanjing, China
Unknown Facility
Shanghai, China
Unknown Facility
Shenyang, China
Unknown Facility
Suzhou, China
Unknown Facility
Tianjin, China
Unknown Facility
Wuhan, China
Unknown Facility
Xi'an, China
Unknown Facility
Barranquilla, Colombia
Unknown Facility
Barranquilla Atlántico Atlanti, Colombia
Unknown Facility
Bogota D C, Colombia
Unknown Facility
Bogota Dc, Colombia
Unknown Facility
Bogotá Dc Dc, Colombia
Unknown Facility
Bogotá Dc, Colombia
Unknown Facility
Cali Valle Del Cauca, Colombia
Unknown Facility
Cali Valley Del Cauca, Colombia
Unknown Facility
Medellin Antioquia, Colombia
Unknown Facility
Medellín, Colombia
Unknown Facility
Santander, Colombia
Unknown Facility
Brno, Czechia
Unknown Facility
Chomutov, Czechia
Unknown Facility
Hradec Králové, Czechia
Unknown Facility
Kutná Hora, Czechia
Unknown Facility
Liberec, Czechia
Unknown Facility
Litomyšl, Czechia
Unknown Facility
Náchod, Czechia
Unknown Facility
Olomouc, Czechia
Unknown Facility
Ostrava, Czechia
Unknown Facility
Pardubice, Czechia
Unknown Facility
Prague, Czechia
Unknown Facility
Praha 10 N/A, Czechia
Unknown Facility
Ráj, Czechia
Unknown Facility
Slaný, Czechia
Unknown Facility
Svitavy, Czechia
Unknown Facility
Trutnov, Czechia
Unknown Facility
Uherské Hradistì 6, Czechia
Unknown Facility
Zlín, Czechia
Unknown Facility
Copenhagen, Denmark
Unknown Facility
Elsinore, Denmark
Unknown Facility
Esbjerg, Denmark
Unknown Facility
Frederiksberg, Denmark
Unknown Facility
Gentofte Municipality, Denmark
Unknown Facility
Hellerup, Denmark
Unknown Facility
Hvidovre, Denmark
Unknown Facility
Koege, Denmark
Unknown Facility
Næstved, Denmark
Unknown Facility
Roskilde, Denmark
Unknown Facility
Slagelse, Denmark
Unknown Facility
Viborg, Denmark
Unknown Facility
Helsinki, Finland
Unknown Facility
Jyväskylä, Finland
Unknown Facility
Kuopio, Finland
Unknown Facility
Mikkeli, Finland
Unknown Facility
Oulu, Finland
Unknown Facility
Turku, Finland
Unknown Facility
Albi, France
Unknown Facility
Arras, France
Unknown Facility
Bayonne, France
Unknown Facility
Belfort, France
Unknown Facility
Besançon, France
Unknown Facility
Béziers Languedoc-Roussillon, France
Unknown Facility
Bourg-en-Bresse, France
Unknown Facility
Brest, France
Unknown Facility
Carcassonne, France
Unknown Facility
Clermont-Ferrand, France
Unknown Facility
Corbeil-Essonnes, France
Unknown Facility
Lille, France
Unknown Facility
Marseille, France
Unknown Facility
Montbéliard, France
Unknown Facility
Montpellier, France
Unknown Facility
Paris, France
Unknown Facility
Perpignan, France
Unknown Facility
Poitiers, France
Unknown Facility
Saint-Brieuc, France
Unknown Facility
Saint-Jean-de-Verges, France
Unknown Facility
Strasbourg, France
Unknown Facility
Thionville, France
Unknown Facility
Toulouse, France
Unknown Facility
Trélivan, France
Unknown Facility
Aalen, Germany
Unknown Facility
Berlin, Germany
Unknown Facility
Berlin/Spandau, Germany
Unknown Facility
Biberach, Germany
Unknown Facility
Bochum, Germany
Unknown Facility
Bonn, Germany
Unknown Facility
Chemnitz, Germany
Unknown Facility
Coburg, Germany
Unknown Facility
Dachau, Germany
Unknown Facility
Dortmund, Germany
Unknown Facility
Dresden, Germany
Unknown Facility
Duisburg, Germany
Unknown Facility
Ebersbach, Germany
Unknown Facility
Eilenburg, Germany
Unknown Facility
Erfurt, Germany
Unknown Facility
Essen, Germany
Unknown Facility
Frankfurt, Germany
Unknown Facility
Freiburg im Breisgau, Germany
Unknown Facility
Greifswald, Germany
Unknown Facility
Halle, Germany
Unknown Facility
Hamburg, Germany
Unknown Facility
Hartmannsdorf, Germany
Unknown Facility
Heidelberg, Germany
Unknown Facility
Henstedt-Rhen, Germany
Unknown Facility
Herford, Germany
Unknown Facility
Homburg/Saar, Germany
Unknown Facility
Jena, Germany
Unknown Facility
Jülich, Germany
Unknown Facility
Kamen, Germany
Unknown Facility
Karlsbad, Germany
Unknown Facility
Kassel, Germany
Unknown Facility
Kirchzarten, Germany
Unknown Facility
Krefeld, Germany
Unknown Facility
Leipzig, Germany
Unknown Facility
Ludwigsburg, Germany
Unknown Facility
Ludwigshafen, Germany
Unknown Facility
Lüneburg, Germany
Unknown Facility
Magdeburg, Germany
Unknown Facility
Mainz, Germany
Unknown Facility
Mannheim, Germany
Unknown Facility
Markkleeberg, Germany
Unknown Facility
Meißen, Germany
Unknown Facility
Melsungen, Germany
Unknown Facility
Mönchengladbach, Germany
Unknown Facility
Mühldorf, Germany
Unknown Facility
Mülheim, Germany
Unknown Facility
München, Germany
Unknown Facility
Münster, Germany
Unknown Facility
Neuwied, Germany
Unknown Facility
Nienburg, Germany
Unknown Facility
Nuremberg, Germany
Unknown Facility
Paderborn, Germany
Unknown Facility
Potsdam, Germany
Unknown Facility
Riesa, Germany
Unknown Facility
Rottweil, Germany
Unknown Facility
Sachsen, Germany
Unknown Facility
Siegen, Germany
Unknown Facility
Ulm, Germany
Unknown Facility
Wermsdorf, Germany
Unknown Facility
Witten, Germany
Unknown Facility
Wolmirstedt, Germany
Unknown Facility
Wuppertal, Germany
Unknown Facility
Athens Attica, Greece
Unknown Facility
Ioannina, Greece
Unknown Facility
Maroussi Athens, Greece
Unknown Facility
Pátrai, Greece
Unknown Facility
Piraeus Attica, Greece
Unknown Facility
Tripoli, Greece
Unknown Facility
Voula Attica, Greece
Unknown Facility
Aberdeen, Hong Kong
Unknown Facility
Hong Kong, Hong Kong
Unknown Facility
Kln, Hong Kong
Unknown Facility
Shatin, Hong Kong
Unknown Facility
Budapest, Hungary
Unknown Facility
Budapest Nap, Hungary
Unknown Facility
Debrecen County, Hungary
Unknown Facility
Eger, Hungary
Unknown Facility
Gyõr, Hungary
Unknown Facility
Gyöngyös, Hungary
Unknown Facility
Kesckemet, Hungary
Unknown Facility
Miskolc, Hungary
Unknown Facility
Nyíregyháza, Hungary
Unknown Facility
Pécs, Hungary
Unknown Facility
Szeged, Hungary
Unknown Facility
Szekszárd, Hungary
Unknown Facility
Szombathely, Hungary
Unknown Facility
Veszprém, Hungary
Unknown Facility
Zalaegerszeg, Hungary
Unknown Facility
Ahmedabad, India
Unknown Facility
Bangalore, India
Unknown Facility
Bikaner, India
Unknown Facility
Chennai, India
Unknown Facility
Coimbatore, India
Unknown Facility
Gandhinagar Guiarat, India
Unknown Facility
Hyderabad, India
Unknown Facility
Hyderabad Andra Pradesh, India
Unknown Facility
Jalandhar, India
Unknown Facility
Madurai, India
Unknown Facility
Mangalore, India
Unknown Facility
Mumbai, India
Unknown Facility
Mysore, India
Unknown Facility
New Delhi, India
Unknown Facility
Pune, India
Unknown Facility
Sūraj, India
Unknown Facility
Vadodara, India
Unknown Facility
Visakhapatnam, India
Unknown Facility
Afula, Israel
Unknown Facility
Ashkelon, Israel
Unknown Facility
Hadera, Israel
Unknown Facility
Haifa, Israel
Unknown Facility
Holon, Israel
Unknown Facility
Jerusalem, Israel
Unknown Facility
Nazareth, Israel
Unknown Facility
Netanya, Israel
Unknown Facility
Petah Tikva, Israel
Unknown Facility
Poria – Neve Oved, Israel
Unknown Facility
Rehovot, Israel
Unknown Facility
Safed, Israel
Unknown Facility
Tel Aviv, Israel
Unknown Facility
Tel Litwinsky, Israel
Unknown Facility
Ẕerifin, Israel
Unknown Facility
Kaunas, Lithuania
Unknown Facility
Klaipėda, Lithuania
Unknown Facility
Panevezys, Lithuania
Unknown Facility
Šiauliai, Lithuania
Unknown Facility
Vilnius, Lithuania
Unknown Facility
Kelantan, Malaysia
Unknown Facility
Kuala Lumpur, Malaysia
Unknown Facility
Sarawak, Malaysia
Unknown Facility
Aguascalientes, Mexico
Unknown Facility
Culiacán Sinaloa/Mèxico, Mexico
Unknown Facility
Guadalajara, Mexico
Unknown Facility
Hermosillo, Mexico
Unknown Facility
Mexico City, Mexico
Unknown Facility
Monterrey, Mexico
Unknown Facility
Monterrey Nuevo Leòn, Mexico
Unknown Facility
Querétaro, Mexico
Unknown Facility
San Luis Potosí City, Mexico
Unknown Facility
Sinaloa, Mexico
Unknown Facility
Zapopan, Mexico
Unknown Facility
's-Hertogenbosch, Netherlands
Unknown Facility
Alkmaar, Netherlands
Unknown Facility
Amersfoort, Netherlands
Unknown Facility
Amsterdam, Netherlands
Unknown Facility
Blaricum, Netherlands
Unknown Facility
Delft, Netherlands
Unknown Facility
Gc Tilburg, Netherlands
Unknown Facility
Gouda, Netherlands
Unknown Facility
Groningen, Netherlands
Unknown Facility
Haarlem, Netherlands
Unknown Facility
Heerlen, Netherlands
Unknown Facility
Hoofddorp, Netherlands
Unknown Facility
Hoorn, Netherlands
Unknown Facility
Leeuwarden, Netherlands
Unknown Facility
Leidschendam, Netherlands
Unknown Facility
Maastricht, Netherlands
Unknown Facility
Meppel, Netherlands
Unknown Facility
Nijmegen, Netherlands
Unknown Facility
Schiedam, Netherlands
Unknown Facility
The Hague, Netherlands
Unknown Facility
Veldhoven, Netherlands
Unknown Facility
Christchurch, New Zealand
Unknown Facility
Dunedin, New Zealand
Unknown Facility
Grafton, New Zealand
Unknown Facility
Hamilton, New Zealand
Unknown Facility
Takapuna Auckland, New Zealand
Unknown Facility
Wellington, New Zealand
Unknown Facility
Ålesund, Norway
Unknown Facility
Bergen, Norway
Unknown Facility
Elverum, Norway
Unknown Facility
Hamar, Norway
Unknown Facility
Jessheim, Norway
Unknown Facility
Lillehammer, Norway
Unknown Facility
Moss, Norway
Unknown Facility
Oslo, Norway
Unknown Facility
Sandefjord, Norway
Unknown Facility
Sandnes, Norway
Unknown Facility
Sandvika, Norway
Unknown Facility
Skedsmokorset, Norway
Unknown Facility
L41 Lima Lima, Peru
Unknown Facility
Lima, Peru
Unknown Facility
Lima 1 Lima Lima, Peru
Unknown Facility
Cebuu City, Philippines
Unknown Facility
Davao City, Philippines
Unknown Facility
Iloilo City, Philippines
Unknown Facility
Manila, Philippines
Unknown Facility
Quezon City, Philippines
Unknown Facility
Bydgoszcz, Poland
Unknown Facility
Gdansk, Poland
Unknown Facility
Gdynia, Poland
Unknown Facility
Katowice, Poland
Unknown Facility
Katowice-Ochojec, Poland
Unknown Facility
Krakow, Poland
Unknown Facility
Lodz, Poland
Unknown Facility
Olsztyn, Poland
Unknown Facility
Opole, Poland
Unknown Facility
Ostrowiec, Poland
Unknown Facility
Oława, Poland
Unknown Facility
Piotrkow Trybunalski, Poland
Unknown Facility
Poznan, Poland
Unknown Facility
Płock, Poland
Unknown Facility
Siedlce, Poland
Unknown Facility
Sieradz, Poland
Unknown Facility
Skierniewice, Poland
Unknown Facility
Starogard Gdanski Nap, Poland
Unknown Facility
Szczecin, Poland
Unknown Facility
Szczecin Nap, Poland
Unknown Facility
Torun, Poland
Unknown Facility
Warsaw, Poland
Unknown Facility
Wroclaw, Poland
Unknown Facility
Włocławek, Poland
Unknown Facility
Żyrardów, Poland
Unknown Facility
Brasov, Romania
Unknown Facility
Bucharest, Romania
Unknown Facility
Craiova, Romania
Unknown Facility
Focşani, Romania
Unknown Facility
Iași, Romania
Unknown Facility
Oradea, Romania
Unknown Facility
Sibiu, Romania
Unknown Facility
Suceava, Romania
Unknown Facility
Tg Mures, Romania
Unknown Facility
Timișoara, Romania
Unknown Facility
Barnaul, Russia
Unknown Facility
Chelyabinsk, Russia
Unknown Facility
Chelyabinsk Chelyabinsk Region, Russia
Unknown Facility
Kemerovo, Russia
Unknown Facility
Krasnoyarsk, Russia
Unknown Facility
Moscow, Russia
Unknown Facility
Nizhny Novgorod, Russia
Unknown Facility
Novosibirsk, Russia
Unknown Facility
Novosibirsk Nap, Russia
Unknown Facility
Orenburg, Russia
Unknown Facility
Perm, Russia
Unknown Facility
Ryazan, Russia
Unknown Facility
Saint Petersburg, Russia
Unknown Facility
Saratov, Russia
Unknown Facility
Smolensk, Russia
Unknown Facility
Tomsk, Russia
Unknown Facility
Tyumen Tyumen Region, Russia
Unknown Facility
Yaroslavl, Russia
Unknown Facility
Yaroslavl Nap, Russia
Unknown Facility
Yekaterinburg, Russia
Unknown Facility
Singapore, Singapore
Unknown Facility
Bloemfontein Free State, South Africa
Unknown Facility
Bloemfontein Orange Free State, South Africa
Unknown Facility
Cape Town, South Africa
Unknown Facility
Cape Town Western Cape, South Africa
Unknown Facility
Centurion Gauteng, South Africa
Unknown Facility
Durban Kwa Zulu Natal, South Africa
Unknown Facility
Johannesburg Gauteng, South Africa
Unknown Facility
Kempton Park Gauteng, South Africa
Unknown Facility
Port Elizabeth Eastern Cape, South Africa
Unknown Facility
Pretoria Gauteng, South Africa
Unknown Facility
Somerset West Western Cape, South Africa
Unknown Facility
Vanderbijlpark, South Africa
Unknown Facility
Worcester Western Cape, South Africa
Unknown Facility
Anyang, South Korea
Unknown Facility
Daegu, South Korea
Unknown Facility
Daejeon, South Korea
Unknown Facility
Goyang, South Korea
Unknown Facility
Kyonggi-Do, South Korea
Unknown Facility
Pusan, South Korea
Unknown Facility
Seoul, South Korea
Unknown Facility
Sungnam, South Korea
Unknown Facility
Suwon, South Korea
Unknown Facility
A Coruña, Spain
Unknown Facility
Alicante, Spain
Unknown Facility
Almería, Spain
Unknown Facility
Baracaldo Vizcaya, Spain
Unknown Facility
Barcelona, Spain
Unknown Facility
Burgos, Spain
Unknown Facility
Guadalajara, Spain
Unknown Facility
La Corona, Spain
Unknown Facility
Madrid, Spain
Unknown Facility
Málaga, Spain
Unknown Facility
Oviedo, Spain
Unknown Facility
Palma de Mallorca, Spain
Unknown Facility
Pamplona, Spain
Unknown Facility
Pontevedra, Spain
Unknown Facility
Sabadell, Spain
Unknown Facility
San Sebastián Guipúzcoa, Spain
Unknown Facility
Seville, Spain
Unknown Facility
Terrassa, Spain
Unknown Facility
Valencia, Spain
Unknown Facility
Valladolid, Spain
Unknown Facility
Ljungby, Sweden
Unknown Facility
Lund, Sweden
Unknown Facility
Sala, Sweden
Unknown Facility
Skövde, Sweden
Unknown Facility
Uppsala, Sweden
Unknown Facility
Basel Bs, Switzerland
Unknown Facility
Bruderholz, Switzerland
Unknown Facility
Geneva, Switzerland
Unknown Facility
Zurich, Switzerland
Unknown Facility
Changhua, Taiwan
Unknown Facility
Kaohsiung City, Taiwan
Unknown Facility
Taichung, Taiwan
Unknown Facility
Tainan, Taiwan
Unknown Facility
Taipei, Taiwan
Unknown Facility
Tamshui, Taiwan
Unknown Facility
Taoyuan District, Taiwan
Unknown Facility
Bangkok, Thailand
Unknown Facility
Bangkok Noi, Thailand
Unknown Facility
Chiang Mai, Thailand
Unknown Facility
Pathum Thani, Thailand
Unknown Facility
Phathumwan, Thailand
Unknown Facility
Ratchatewi, Thailand
Unknown Facility
Adana, Turkey (Türkiye)
Unknown Facility
Ankara, Turkey (Türkiye)
Unknown Facility
Antalya, Turkey (Türkiye)
Unknown Facility
Aydin, Turkey (Türkiye)
Unknown Facility
Denizli, Turkey (Türkiye)
Unknown Facility
Diyarbakır, Turkey (Türkiye)
Unknown Facility
Eskişehir, Turkey (Türkiye)
Unknown Facility
Görükle, Turkey (Türkiye)
Unknown Facility
Istanbul, Turkey (Türkiye)
Unknown Facility
Izmir, Turkey (Türkiye)
Unknown Facility
İzmit, Turkey (Türkiye)
Unknown Facility
Kayseri, Turkey (Türkiye)
Unknown Facility
Konya, Turkey (Türkiye)
Unknown Facility
Malatya Nap, Turkey (Türkiye)
Unknown Facility
Mersin, Turkey (Türkiye)
Unknown Facility
Samsun, Turkey (Türkiye)
Unknown Facility
Cherkassy, Ukraine
Unknown Facility
Chernihiv, Ukraine
Unknown Facility
Dnipro, Ukraine
Unknown Facility
Dnipropetrovsk, Ukraine
Unknown Facility
Donetsk, Ukraine
Unknown Facility
Ivano-Frankivsk, Ukraine
Unknown Facility
Kharkiv, Ukraine
Unknown Facility
Kirovograd, Ukraine
Unknown Facility
Kyiv, Ukraine
Unknown Facility
Luhansk, Ukraine
Unknown Facility
Lviv, Ukraine
Unknown Facility
O1103 Kyiv, Ukraine
Unknown Facility
Odesa, Ukraine
Unknown Facility
Poltava, Ukraine
Unknown Facility
Simferopil, Ukraine
Unknown Facility
Sumy, Ukraine
Unknown Facility
Ternopil, Ukraine
Unknown Facility
Uzhhorod, Ukraine
Unknown Facility
Vinnitsya, Ukraine
Unknown Facility
Vinnytsia, Ukraine
Unknown Facility
Zaporizhzhya, Ukraine
Unknown Facility
Zhytomyr, Ukraine
Unknown Facility
Aberdeen, United Kingdom
Unknown Facility
Belfast, United Kingdom
Unknown Facility
Birmingham, United Kingdom
Unknown Facility
Bournemouth, United Kingdom
Unknown Facility
Cambridgeshire, United Kingdom
Unknown Facility
Chelmsford, United Kingdom
Unknown Facility
Chesterfield, United Kingdom
Unknown Facility
Colchester, United Kingdom
Unknown Facility
Craigavon, United Kingdom
Unknown Facility
Devon, United Kingdom
Unknown Facility
Dundee, United Kingdom
Unknown Facility
Glasgow, United Kingdom
Unknown Facility
Harrogate, United Kingdom
Unknown Facility
Hull, United Kingdom
Unknown Facility
Leicester, United Kingdom
Unknown Facility
Lincoln, United Kingdom
Unknown Facility
Liverpool, United Kingdom
Unknown Facility
London, United Kingdom
Unknown Facility
Nottingham, United Kingdom
Unknown Facility
Plymouth, United Kingdom
Unknown Facility
Romford, United Kingdom
Unknown Facility
Sheffield, United Kingdom
Unknown Facility
Stirling, United Kingdom
Unknown Facility
Stoke-on-Trent, United Kingdom
Unknown Facility
York, United Kingdom
Unknown Facility
Caracas, Venezuela
Unknown Facility
Maracaibo Estado Zulia, Venezuela
Unknown Facility
Maracay Estado Aragua, Venezuela
Related Publications (27)
Dobesh PP, Volkl AA, Pap AF, Damaraju CV, Levitan B, Yuan Z, Amin AN. Benefit-Risk Assessment of Rivaroxaban in Older Patients With Nonvalvular Atrial Fibrillation or Venous Thromboembolism. Drugs Aging. 2025 May;42(5):469-484. doi: 10.1007/s40266-025-01192-7. Epub 2025 Mar 31.
PMID: 40163217DERIVEDUngar L, Rodriguez F, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Nessel CC, Singer DE, Patel MR, Piccini JP, Mahaffey KW. Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF. Cardiol Ther. 2019 Dec;8(2):283-295. doi: 10.1007/s40119-019-00146-6. Epub 2019 Aug 2.
PMID: 31376090DERIVEDQuinn GR, Hellkamp AS, Hankey GJ, Becker RC, Berkowitz SD, Breithardt G, Fava M, Fox KAA, Halperin JL, Mahaffey KW, Nessel CC, Patel MR, Piccini JP, Singer DE. Selective Serotonin Reuptake Inhibitors and Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: An Analysis From the ROCKET AF Trial. J Am Heart Assoc. 2018 Aug 7;7(15):e008755. doi: 10.1161/JAHA.118.008755.
PMID: 30371223DERIVEDChen ST, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR, Melloni C. Efficacy and safety of rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation and a history of cancer: observations from ROCKET AF. Eur Heart J Qual Care Clin Outcomes. 2019 Apr 1;5(2):145-152. doi: 10.1093/ehjqcco/qcy040.
PMID: 30219887DERIVEDChen ST, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR. Impact of polyvascular disease on patients with atrial fibrillation: Insights from ROCKET AF. Am Heart J. 2018 Jun;200:102-109. doi: 10.1016/j.ahj.2018.02.013. Epub 2018 Feb 27.
PMID: 29898836DERIVEDLeef GC, Hellkamp AS, Patel MR, Becker RC, Berkowitz SD, Breithardt G, Halperin JL, Hankey GJ, Hacke W, Nessel CC, Singer DE, Fox KAA, Mahaffey KW, Piccini JP. Safety and Efficacy of Rivaroxaban in Patients With Cardiac Implantable Electronic Devices: Observations From the ROCKET AF Trial. J Am Heart Assoc. 2017 Jun 14;6(6):e004663. doi: 10.1161/JAHA.116.004663.
PMID: 28615214DERIVEDBalla SR, Cyr DD, Lokhnygina Y, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR. Relation of Risk of Stroke in Patients With Atrial Fibrillation to Body Mass Index (from Patients Treated With Rivaroxaban and Warfarin in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation Trial). Am J Cardiol. 2017 Jun 15;119(12):1989-1996. doi: 10.1016/j.amjcard.2017.03.028. Epub 2017 Mar 29.
PMID: 28477860DERIVEDSun Y, Hu D, Stevens S, Lokhnygina Y, Becker RC, Berkowitz SD, Breithardt G, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Fox KAA, Patel MR. Efficacy and safety of rivaroxaban versus warfarin in patients from mainland China with nonvalvular atrial fibrillation: A subgroup analysis from the ROCKET AF trial. Thromb Res. 2017 Aug;156:184-190. doi: 10.1016/j.thromres.2017.04.010. Epub 2017 Apr 13.
PMID: 28433206DERIVEDLindner SM, Fordyce CB, Hellkamp AS, Lokhnygina Y, Piccini JP, Breithardt G, Mahaffey KW, Singer DE, Hacke W, Halperin JL, Hankey GJ, Berkowitz SD, Nessel CC, Becker RC, Fox KA, Patel MR; ROCKET AF Steering Committee and Investigators. Treatment Consistency Across Levels of Baseline Renal Function With Rivaroxaban or Warfarin: A ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) Analysis. Circulation. 2017 Mar 7;135(10):1001-1003. doi: 10.1161/CIRCULATIONAHA.116.024666. No abstract available.
PMID: 28264892DERIVEDFordyce CB, Hellkamp AS, Lokhnygina Y, Lindner SM, Piccini JP, Becker RC, Berkowitz SD, Breithardt G, Fox KA, Mahaffey KW, Nessel CC, Singer DE, Patel MR; ROCKET AF Steering Committee and Investigators. On-Treatment Outcomes in Patients With Worsening Renal Function With Rivaroxaban Compared With Warfarin: Insights From ROCKET AF. Circulation. 2016 Jul 5;134(1):37-47. doi: 10.1161/CIRCULATIONAHA.116.021890.
PMID: 27358435DERIVEDPokorney SD, Piccini JP, Stevens SR, Patel MR, Pieper KS, Halperin JL, Breithardt G, Singer DE, Hankey GJ, Hacke W, Becker RC, Berkowitz SD, Nessel CC, Mahaffey KW, Fox KA, Califf RM; ROCKET AF Steering Committee & Investigators; ROCKET AF Steering Committee Investigators. Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF. J Am Heart Assoc. 2016 Mar 8;5(3):e002197. doi: 10.1161/JAHA.115.002197.
PMID: 26955859DERIVEDBreithardt G, Baumgartner H, Berkowitz SD, Hellkamp AS, Piccini JP, Lokhnygina Y, Halperin JL, Singer DE, Hankey GJ, Hacke W, Becker RC, Nessel CC, Mahaffey KW, Califf RM, Fox KA, Patel MR; ROCKET AF Steering Committee & Investigators. Native valve disease in patients with non-valvular atrial fibrillation on warfarin or rivaroxaban. Heart. 2016 Jul 1;102(13):1036-43. doi: 10.1136/heartjnl-2015-308120. Epub 2016 Feb 17.
PMID: 26888572DERIVEDPiccini JP, Hellkamp AS, Washam JB, Becker RC, Breithardt G, Berkowitz SD, Halperin JL, Hankey GJ, Hacke W, Mahaffey KW, Nessel CC, Singer DE, Fox KA, Patel MR. Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation. Circulation. 2016 Jan 26;133(4):352-60. doi: 10.1161/CIRCULATIONAHA.115.018544. Epub 2015 Dec 16.
PMID: 26673560DERIVEDBansilal S, Bloomgarden Z, Halperin JL, Hellkamp AS, Lokhnygina Y, Patel MR, Becker RC, Breithardt G, Hacke W, Hankey GJ, Nessel CC, Singer DE, Berkowitz SD, Piccini JP, Mahaffey KW, Fox KA; ROCKET AF Steering Committee and Investigators. Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial fibrillation: the Rivaroxaban Once-daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF Trial). Am Heart J. 2015 Oct;170(4):675-682.e8. doi: 10.1016/j.ahj.2015.07.006. Epub 2015 Jul 17.
PMID: 26386791DERIVEDWasham JB, Stevens SR, Lokhnygina Y, Halperin JL, Breithardt G, Singer DE, Mahaffey KW, Hankey GJ, Berkowitz SD, Nessel CC, Fox KA, Califf RM, Piccini JP, Patel MR; ROCKET AF Steering Committee and Investigators. Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Lancet. 2015 Jun 13;385(9985):2363-70. doi: 10.1016/S0140-6736(14)61836-5. Epub 2015 Mar 6.
PMID: 25749644DERIVEDSinger DE, Hellkamp AS, Yuan Z, Lokhnygina Y, Patel MR, Piccini JP, Hankey GJ, Breithardt G, Halperin JL, Becker RC, Hacke W, Nessel CC, Mahaffey KW, Fox KA, Califf RM; ROCKET AF Investigators. Alternative calculations of individual patient time in therapeutic range while taking warfarin: results from the ROCKET AF trial. J Am Heart Assoc. 2015 Mar 3;4(3):e001349. doi: 10.1161/JAHA.114.001349.
PMID: 25736441DERIVEDGirgis IG, Patel MR, Peters GR, Moore KT, Mahaffey KW, Nessel CC, Halperin JL, Califf RM, Fox KA, Becker RC. Population pharmacokinetics and pharmacodynamics of rivaroxaban in patients with non-valvular atrial fibrillation: results from ROCKET AF. J Clin Pharmacol. 2014 Aug;54(8):917-27. doi: 10.1002/jcph.288. Epub 2014 Mar 26.
PMID: 24668660DERIVEDSherwood MW, Douketis JD, Patel MR, Piccini JP, Hellkamp AS, Lokhnygina Y, Spyropoulos AC, Hankey GJ, Singer DE, Nessel CC, Mahaffey KW, Fox KA, Califf RM, Becker RC; ROCKET AF Investigators. Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF). Circulation. 2014 May 6;129(18):1850-9. doi: 10.1161/CIRCULATIONAHA.113.005754. Epub 2014 Feb 19.
PMID: 24552831DERIVEDGoodman SG, Wojdyla DM, Piccini JP, White HD, Paolini JF, Nessel CC, Berkowitz SD, Mahaffey KW, Patel MR, Sherwood MW, Becker RC, Halperin JL, Hacke W, Singer DE, Hankey GJ, Breithardt G, Fox KA, Califf RM; ROCKET AF Investigators. Factors associated with major bleeding events: insights from the ROCKET AF trial (rivaroxaban once-daily oral direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation). J Am Coll Cardiol. 2014 Mar 11;63(9):891-900. doi: 10.1016/j.jacc.2013.11.013. Epub 2013 Dec 4.
PMID: 24315894DERIVEDMahaffey KW, Wojdyla D, Hankey GJ, White HD, Nessel CC, Piccini JP, Patel MR, Berkowitz SD, Becker RC, Halperin JL, Singer DE, Califf RM, Fox KA, Breithardt G, Hacke W. Clinical outcomes with rivaroxaban in patients transitioned from vitamin K antagonist therapy: a subgroup analysis of a randomized trial. Ann Intern Med. 2013 Jun 18;158(12):861-8. doi: 10.7326/0003-4819-158-12-201306180-00003.
PMID: 23778903DERIVEDvan Diepen S, Hellkamp AS, Patel MR, Becker RC, Breithardt G, Hacke W, Halperin JL, Hankey GJ, Nessel CC, Singer DE, Berkowitz SD, Califf RM, Fox KA, Mahaffey KW. Efficacy and safety of rivaroxaban in patients with heart failure and nonvalvular atrial fibrillation: insights from ROCKET AF. Circ Heart Fail. 2013 Jul;6(4):740-7. doi: 10.1161/CIRCHEARTFAILURE.113.000212. Epub 2013 May 30.
PMID: 23723250DERIVEDSinger DE, Hellkamp AS, Piccini JP, Mahaffey KW, Lokhnygina Y, Pan G, Halperin JL, Becker RC, Breithardt G, Hankey GJ, Hacke W, Nessel CC, Patel MR, Califf RM, Fox KA; ROCKET AF Investigators. Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial. J Am Heart Assoc. 2013 Feb 19;2(1):e000067. doi: 10.1161/JAHA.112.000067.
PMID: 23525418DERIVEDPiccini JP, Stevens SR, Lokhnygina Y, Patel MR, Halperin JL, Singer DE, Hankey GJ, Hacke W, Becker RC, Nessel CC, Mahaffey KW, Fox KA, Califf RM, Breithardt G; ROCKET AF Steering Committee & Investigators. Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial. J Am Coll Cardiol. 2013 May 14;61(19):1998-2006. doi: 10.1016/j.jacc.2013.02.025. Epub 2013 Mar 14.
PMID: 23500298DERIVEDPiccini JP, Stevens SR, Chang Y, Singer DE, Lokhnygina Y, Go AS, Patel MR, Mahaffey KW, Halperin JL, Breithardt G, Hankey GJ, Hacke W, Becker RC, Nessel CC, Fox KA, Califf RM; ROCKET AF Steering Committee and Investigators. Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts. Circulation. 2013 Jan 15;127(2):224-32. doi: 10.1161/CIRCULATIONAHA.112.107128. Epub 2012 Dec 3.
PMID: 23212720DERIVEDHankey GJ, Patel MR, Stevens SR, Becker RC, Breithardt G, Carolei A, Diener HC, Donnan GA, Halperin JL, Mahaffey KW, Mas JL, Massaro A, Norrving B, Nessel CC, Paolini JF, Roine RO, Singer DE, Wong L, Califf RM, Fox KA, Hacke W; ROCKET AF Steering Committee Investigators. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol. 2012 Apr;11(4):315-22. doi: 10.1016/S1474-4422(12)70042-X. Epub 2012 Mar 7.
PMID: 22402056DERIVEDPatel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP, Becker RC, Nessel CC, Paolini JF, Berkowitz SD, Fox KA, Califf RM; ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011 Sep 8;365(10):883-91. doi: 10.1056/NEJMoa1009638. Epub 2011 Aug 10.
PMID: 21830957DERIVEDROCKET AF Study Investigators. Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study. Am Heart J. 2010 Mar;159(3):340-347.e1. doi: 10.1016/j.ahj.2009.11.025.
PMID: 20211293DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Head of Development, CV & UROL
- Organization
- Johnson & Johnson Pharmaceutical Research & Development L.L.C.
Study Officials
- STUDY DIRECTOR
Johnson & Johnson Pharmaceutical Research & Development, L.L. C. Clinical Trial
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- LTE60
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 23, 2006
First Posted
November 27, 2006
Study Start
December 1, 2006
Primary Completion
September 1, 2010
Study Completion
September 1, 2010
Last Updated
April 29, 2014
Results First Posted
July 17, 2012
Record last verified: 2014-04